ChemicalBook >제품 카탈로그 >생화학 공학>억제제>단백질 티로신 키나아제>2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]-

2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]-

2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]- 구조식 이미지

카스 번호:: 194423-06-8

상품명:: 2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]-

동의어(영문):: 785;CL-387;EKB 785;CS-1630;-387785;CL-38875;WAY-EKI 785;CL-387785, >=98%;EKI-785 CL-38875;CL-387785 (EKI-785)

CBNumber:: CB92626313

분자식:: C18H13BrN4O

포뮬러 무게:: 381.23

MOL 파일:: 194423-06-8.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 86

2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]- 속성

녹는점: 276 °C

밀도: 1.577±0.06 g/cm3(Predicted)

저장 조건: Sealed in dry,Store in freezer, under -20°C

용해도: insoluble in EtOH; insoluble in H2O; ≥16.85 mg/mL in DMSO

산도 계수 (pKa): 9.84±0.43(Predicted)

물리적 상태: 회백색 내지 황색 고체.

색상: White to Orange to Green

안전

HS 번호	2933.59.5300

2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]- C화학적 특성, 용도, 생산

개요

Overactivity of epidermal growth factor receptor (EGFR) tyrosine kinase activity has been associated with a number of cancers. CL 387,785 is a potent, irreversible inhibitor of EGFR kinase activity (IC₅₀ = 370 pM). It blocks EGF-stimulated autophosphorylation of receptors in cells (IC₅₀ = 5 nM) and halts cell cycling in cells that overexpress EGFR or c-ErbB2 (IC₅₀s = 31-125 nM). CL 387,785 profoundly blocks the growth of EGFR-overexpressing tumors in nude mice when given orally at 80 mg/kg/day for 10 days.

용도

CL-387785 (EKI-785) is an irreversible and selective EGFR inhibitor showing activity against mutations of the receptor. Potential therapeutic against various type of cancer, including lung cancer.

정의

ChEBI: A member of the class of quinazolines that is 4,6-diaminoquinazoine in which the one of the hydrogens attached to the amino group at position 4 has been replaced by a m-bromophenyl group while one of the hydrogens attached to the amino group a position 6 has been replaced by a but-2-ynoyl group.

2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]- 준비 용품 및 원자재

원자재

준비 용품

2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]- 공급 업체

글로벌( 86)공급 업체

공급자	전화	이메일	국가	제품 수	이점
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32836	60
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29825	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd	+86-86-22-87899925 +86-8618522618860	18522618860@163.com	China	694	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	24295	58
Shenzhen Shengda Pharma Limited	755-85269922 +8613424394241	sales@shengdapharm.com	CHINA	310	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10522	58

2-ButynaMide, N-[4-[(3-broMophenyl)aMino]-6-quinazolinyl]- 관련 검색:

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