FOXO4-DRI

FOXO4-DRI C화학적 특성, 용도, 생산

개요

FOXO4-DRI (Retro-Inverso) is a synthetic, slightly modified version of the standard FOXO4 protein. The modification prolongs half-life of the protein and allows it to interfere with normal FOXO4 function. FOXO4-DRI has been shown in research to prevent normal FOXO4 binding to p53, thereby allowing for elimination of senescent cells, improved organ function, and younger tissue “biological age.” FOXO4-DRI impacts insulin signaling, cell cycle regulation, and oxidative stress signaling pathways. FOXO4-DRI is a cell penetrating peptide shown to selectively induce apoptosis of senescent cells thereby reversing effects of aging in animal studies.

Biological Functions

FOXO4-DRI is a cell-permeable peptide comprising part of the p53-interaction domain of FOXO4.  It can compete with endogenous FOXO4 for p53, thereby disrupting the FOXO4-p53 interaction. Disrupting the p53-FOXO4 interaction causes p53 to be excluded from the nucleus and directed to mitochondria for induction of apoptosis in senescent cells, ultimately eliminating senescent fibroblasts through triggering apoptosis[1-2]. FOXO4-DRI to be selective for ionizing radiation-induced senescent IMR90 cells and safe to normal cells. 

FOXO4-DRI 준비 용품 및 원자재

원자재

준비 용품

FOXO4-DRI 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Hebei Weimiao Import and Export Trade Co., Ltd.	+undefined19948166995	sale01@hbweimiao.com	China	73	58
Nantong Guangyuan Chemicl Co,Ltd	+undefined17712220823	admin@guyunchem.com	China	616	58
Shanghai Affida new material science and technology center	+undefined15081010295	admin@oudaxin.com	China	114	58
Hebei Anlijie Biotechnology Co., Ltd	+8619031013551	ably@aljbio.com	China	145	58
Shijiazhuang Saixin Technology Co., Ltd.	+86-16632312509 +86-16632315022	saixinkeji@aliyun.com	China	90	58
Sichuan Tai Hui Biotechnology Co., Ltd	+86-18224031330 +86-18081096520	404435307@qq.com	China	24	58
Hebei Kangcang new material Technology Co., LTD	+8615713292910	Nancy@kangcang.com.cn	China	341	58
Shanghai Getian Industrial Co., LTD	+86-15373193816 +86-15373193816	mike@ge-tian.com	China	274	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3002	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10260	58