3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one
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3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one 속성
- 녹는점
- 164 °C
- 끓는 점
- 383.2±42.0 °C(Predicted)
- 밀도
- 1.492±0.06 g/cm3(Predicted)
- 인화점
- 185.542℃
- 저장 조건
- Keep in dark place,Sealed in dry,Room Temperature
- 용해도
- slightly soluble in ethanol, benzene, acetone, insoluble in water
- 산도 계수 (pKa)
- 13.59±0.40(Predicted)
- CAS 데이터베이스
- 86499-96-9(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
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3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one C화학적 특성, 용도, 생산
용도
3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one is an intermediate in the synthesis of Benazepril Hydrochloride. Benazepril Hydrochloride is a first-line antihypertensive drug recommended by the WHO. It is a chiral drug with excellent clinical efficacy, strong safety and tiny side effects in the international antihypertensive drugs of angiotensin converting enzyme inhibitors.화학적 성질
White or almost white crystalline제조 방법
The preparation of 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one is as follows:10 parts by weight of the heated melted polyphosphoric acid was added to the drying kettle, With stirring, The above 2-bromo-3,4-dihydro-N-hydroxy- (2H) -naphthalimide was added in portions at a temperature of 60 ° C, Insulation reaction for 20 hours; The reaction solution was added dropwise to 12.5 parts by weight of water to carry out hydrolysis, Still Washed to give 3-bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one crude; 10 parts by weight of methanol and 0.1 part by weight of activated carbon were added, Heating decolorization, After filtration, the filtrate was cooled to 10 ° C for 20 hours, centrifuged, washed and dried to give 3-bromo-1,3,4,5-tetrahydro-2H-1-benzazepan-2-one. The purity of the product was 3, 10-bromo-1,3,4,5-tetrahydro-2H-1-benzazepan-2-one as high as 99.6% and the yield was as high as 98%.
3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one 준비 용품 및 원자재
원자재
1(2H)-Naphthalenone, 2-bromo-3,4-dihydro-, oxime
2-Bromo-1,2,3,4-tetrahydronaphthalen-1-one
1,3,4,5-테트라하이드로-2H-1-벤즈아제핀-2-온
벤젠
1-Tetralone
준비 용품
3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one 공급 업체
글로벌( 301)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| AstaTech(Chengdu) Biopharmaceutical Corp. | +86-02882666559 +86-15884417729 |
gjpu@astatech.com.cn | China | 308 | 58 |
| PRISUN PHARMATECH CO.,LTD | +86-021-54326183-8001 +8618917565227 |
prisun@prisunpharma.com | China | 215 | 58 |
| Zhejiang Karry Pharmachem Co., Ltd. | +8613567161161 |
info@karrypharma.com | China | 34 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 |
peter@yan-xi.com | China | 6011 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20318 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 16208 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21673 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9337 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one 관련 검색:
티아나프텐-2-붕소산 2-브로모에틸아민 브롬화수소산염 3-브로모아니졸 N-메틸-2-피롤리디논 옥시브롬화인 브롬
Epiandrosterone acetate
4'-Bromoacetophenone
2-Bromoacetophenone
Laurocapram
Dehydroepiandrosterone
Tetrahydro-4H-pyran-4-one
1,3,4,5-Tetrahydro-2H-1-benzazepin-2-one
2-bromo-N-(o-tolyl)propionamide
Nitrogen and hydrogen mixed gas
3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one
Tetrahydro