4-아미노피리딘
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4-아미노피리딘 속성
- 녹는점
- 155-158 °C (lit.)
- 끓는 점
- 273 °C (lit.)
- 밀도
- 1.26
- 증기압
- 0.046Pa at 25℃
- 굴절률
- 1.5560 (estimate)
- 인화점
- 156°C
- 저장 조건
- 2-8°C
- 용해도
- H2O: 가용성50mg/mL, 투명, 무색
- 물리적 상태
- 결정질 분말, 고체 또는 결정
- 산도 계수 (pKa)
- 9.114(at 25℃)
- 색상
- 흰색에서 희미한 회색, 연한 노란색까지
- 수용성
- 물에 용해됩니다(20°C에서 112g/L). 에틸 에테르, 벤젠에 용해됩니다. 리그로인에 약간 용해됩니다. 에탄올에 매우 잘 녹습니다. 메탄올, 아세톤, 테트라히드로푸란, 이소프로판올, 아세토니트릴, N,N-디메틸포름아미드, 디메틸술폭시드 및 에탄올에 용해됩니다.
- Merck
- 14,3933
- BRN
- 105782
- 안정성
- 흡습성
- InChIKey
- NUKYPUAOHBNCPY-UHFFFAOYSA-N
- LogP
- -0.76 at pH7.4
- CAS 데이터베이스
- 504-24-5(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T+,N,T,Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 28-36/37/38-51/53-23/24/25 | ||
안전지침서 | 26-36/37/39-45-60-61-37/39-28A-1 | ||
유엔번호(UN No.) | UN 2671 6.1/PG 2 | ||
WGK 독일 | 3 | ||
RTECS 번호 | US1750000 | ||
F 고인화성물질 | 8-21 | ||
자연 발화 온도 | 640 °C | ||
위험 참고 사항 | Toxic/Irritant | ||
TSCA | Yes | ||
위험 등급 | 6.1 | ||
포장분류 | II | ||
HS 번호 | 29333999 | ||
유해 물질 데이터 | 504-24-5(Hazardous Substances Data) | ||
독성 | LD50 orally in Rabbit: 21 mg/kg | ||
기존화학 물질 | KE-29927 | ||
유해화학물질 필터링 | 97-1-449 | ||
함량 및 규제정보 | 물질구분: 유독물질; 혼합물(제품)함량정보: 4-아미노피리딘 및 이를 25% 이상 함유한 혼합물 |
4-아미노피리딘 C화학적 특성, 용도, 생산
용도
4-AP는 탈수초성 시신경병 환자의 시력을 개선시키는 데 유용하다.개요
4-Aminopyridine (4-AP, fampridine, dalfampridine) is the first drug approved by the FDA to improve walking in patients with multiple sclerosis (MS). Dalfampridine is a voltage-gated potassium channel blocker that readily penetrates the CNS and increases the conduction and duration of action potential across nerve fibers resulting in enhanced functionality as observed in the walking speed of MS patients.From a safety perspective, seizure was the most important adverse event from various dalfampridine clinical trials. Therefore, dalfampridine is contraindicated in patients with a history of seizures. Since dalfampridine is primarily excreted by the kidney as unchanged drug, it is also contraindicated in patients with moderate to severe renal impairment. Assessing the overall benefit–risk profile from various clinical trials, the FDA approved dalfampridine (daily oral dose of 10 mg, b.i.d.) to improve walking in MS patients with existing gait impairment.
화학적 성질
4-aminopyridine is a white crystalline solid that contains about 98% active ingredient. It is soluble in water and slightly soluble in benzene and ether. 4-Aminopyridine formulations are classifi ed by the US Environmental Protection Agency (US EPA) as restricted use pesticides (RUPs) and therefore should be purchased and used only by certifi ed and trained workers and applicators. Avitrol is available as grain baits or as a powder concentrate. It is one of the most prominent avicides. It is registered with the EPA for use against red-winged blackbirds, blackbirds in agricultural fi elds, grackles, pigeons, and sparrows around public buildings, and various birds around livestock feeding pens. Avitrol repels birds by poisoning a few members of a fl ock, causing them to become hyperactive.용도
Avitrol (4-aminopyridine), has repellent–toxicant properties for birds and is classed as a severe poison and irritant. This secondary bird repellent can be used as a broadcast bait, causing uncoordinated flight and distress calls and escape responses in nearby birds.정의
ChEBI: 4-aminopyridine is an aromatic amine that is pyridine bearing a single amino substituent at position 4. An orphan drug in the US, it is used to improve walking in adults with multiple sclerosis. It has a role as an avicide, a potassium channel blocker and an orphan drug. It is an aromatic amine and an aminopyridine.일반 설명
White crystalline material with no odor. Used as an avicide, an intermediate and as a fixer for some textile dyes.반응 프로필
4-Aminopyridine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.건강위험
4-Aminopyridine, a pyridine compound, is an extremely effective bird poison. In agriculture, 4-AP is used as an extremely effective bird poison sold under the brand name Avitrol. It is highly toxic to all mammals including humans if dosages are exceeded, and as an experimental drug, the recommended dose data is unavailable.화재위험
Material may produce irritating or poisonous gases in fire. Runoff from fire control water may give off irritating or poisonous gases.Safety Profile
Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: hallucinations and vomiting. When heated to decomposition it emits toxic fumes of NOx,.잠재적 노출
Used as a chemical intermediate in pharmaceuticals; as an agricultural chemical for field crops; and as a bird repellent and poison운송 방법
UN2671 Aminopyridines, Hazard Class: 6.1; Labels: 6.1-Poisonous materialsPurification Methods
Crystallise the aminopyridine from *benzene/EtOH, then recrystallise it twice from water, then crush and dry it for 4hours at 105o [Bates & Hetzer J Res Nat Bur Stand 64A 427 1960]. It has also been crystallised from EtOH, *benzene, *benzene/pet ether, toluene and sublimes in a vacuum. [Beilstein 22/9 V 106.]비 호환성
Sodium nitrite, strong oxidizers. Avoid contact with acid anhydrides, acid chlorides; and strong acids.폐기물 처리
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposalIncineration with nitrogen oxides removal from effluent gas.4-아미노피리딘 준비 용품 및 원자재
원자재
준비 용품
2,2-DIMETHYL-N-PYRIDIN-4-YL-PROPIONAMIDE
efficient polymer catalyst for acrylation-synthesis and characterigation of polyamide containing supernucleophilic reagent
TERT-BUTYL 3-FORMYLPYRIDIN-4-YLCARBAMATE
4-ACETAMIDO-3-AMINOPYRIDINE
4-(Boc-아미노)피리딘
(3-BROMO-PYRIDIN-4-YL)-CARBAMIC ACID TERT-BUTYL ESTER
3-피리딘아세트산,4-[[(1,1-디메틸에톡시)카르보닐]아미노]-A-옥소-,에틸에스테르
4-Iodopyridine
2-chloro-5-ethylaminomethylpyridine
4-Amino-3-nitropyridine
4-Amino-2-bromopyridine
4-PYRIDYLTHIOUREA
3,4-DiaMino-5-broMo-2-클로로피리딘
4-chloropyridine
2,7-di(pyridin-4-yl)benzo[lMn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetraone
4-Amino-3-(trifluoromethyl)pyridine
4-아미노피리딘 공급 업체
글로벌( 570)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12449 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 |
peter@yan-xi.com | China | 5872 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5870 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21668 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9332 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32760 | 60 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 |
info@tnjchem.com | China | 2989 | 55 |
Zjartschem | +86-571 87238903 |
jocelynpan@zjarts.com | CHINA | 993 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29892 | 58 |