2-아미노피리딘
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2-아미노피리딘 속성
- 녹는점
- 59 °C
- 끓는 점
- 204-210 °C(lit.)
- 밀도
- 1.0308 (estimate)
- 증기압
- 5 hPa (125 °C)
- 굴절률
- 1.5560 (estimate)
- 인화점
- 198 °F
- 저장 조건
- Store below +30°C.
- 용해도
- 890g/L
- 물리적 상태
- 결정질 분말, 결정 또는 플레이크
- 산도 계수 (pKa)
- 6.82(at 20℃)
- 색상
- 크림~연한 노란색-베이지색
- 냄새
- 특유의 냄새
- 수용성
- 약간 용해됨. 19ºC에서 1~5g/100mL
- 감도
- Hygroscopic
- Merck
- 14,473
- BRN
- 105785
- 노출 한도
- NIOSH REL: TWA 0.5 ppm (2 mg/m3), IDLH 5 ppm; OSHA PEL: 0.5 ppm; ACGIH TLV: TWA 0.5 ppm.
- LogP
- 0.53
- CAS 데이터베이스
- 504-29-0(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T,Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 21-25-36/37/38-23/24/25 | ||
안전지침서 | 26-36/37/39-45-38-28B | ||
유엔번호(UN No.) | UN 2671 6.1/PG 2 | ||
OEB | B | ||
OEL | TWA: 0.5 ppm (2 mg/m3) | ||
WGK 독일 | 3 | ||
RTECS 번호 | US1575000 | ||
F 고인화성물질 | 8-21 | ||
자연 발화 온도 | >630 °C | ||
위험 참고 사항 | Toxic/Irritant | ||
TSCA | Yes | ||
위험 등급 | 6.1 | ||
포장분류 | II | ||
HS 번호 | 29333999 | ||
유해 물질 데이터 | 504-29-0(Hazardous Substances Data) | ||
독성 | LD50 orally in Rabbit: 200 mg/kg | ||
IDLA | 5 ppm | ||
기존화학 물질 | KE-29925 |
2-아미노피리딘 C화학적 특성, 용도, 생산
화학적 성질
2-Aminopyridine is a yellow or white crystalline (sand-like) solid with a characteristic odor. It is soluble in water, alcohol, benzene, ether and hot petroleum ether. It tastes bitter and has anesthetic effect. It is a significant synthetic synthon, with unique dual nucleophilic structure. It can react with ketones, aldehydes, acids, multifunctional esters, halogenated aromatics and other compounds to synthesize five- and six-member azaheterocycles. after prolonged storage, may darken in color.용도
2-Aminopyridine is used primarily in the pharmaceutical industry as an intermediate in chemical synthesis. It is used to manufacturing analgesic and anti-inflammatory drugs piroxicam and lornoxicam. 2-Aminopyridine is a basic building block of several heterocyclic compounds and Schiff bases. It has been shown to reversibly block voltage-dependent potassium channels, and is also a common impurity from the synthesis of compounds found in hair dyes. It is a derivatizing agent which can be used as a fluorescent label for oligosaccharide detection, chromatographic separation, fluorometric or mass spectrometric analysis. 2AP and its derivatives are good candidates for antimicrobial, anticorrosion and molecular sensing applications.주요 응용
2-Aminopyridine has also been used to derivatize sialyloligosaccharides for detection in FAB-MS. It can also be used:As a reactant in the synthesis of 3-aroylimidazopyridines from chalcones by aerobic oxidative amidation using copper acetate catalyst.
In the synthesis of crystalline Cu(II) complex, di-μ-(2-aminopyridine(N,N′))-bis[(2,6 pyridinedicarboxylate)aquacopper(II)] tetrahydrate using 2,6-pyridinedicarboxylic acid and Cu(CH3COO)2.H2O.
As an imprinting molecule for the preparation of poly(methacrylic acid–ethylene glycol dimethacrylate) polymer. It is packed in micro-column for selective solid phase extraction of 2-aminopyridine.
As a reactant in the synthesis of 2-aryl-3-(pyridin-2-yl)-1,3-thiazolidin-4-ones in the presence of Lewis acid catalysts.
As a reactant in the synthesis of 2-(2-aminopyridinium)acetyl starch with antioxidant property.
제조 방법
2-Aminopyridine is manufactured using the reaction of pyridine with sodium amide (Chichibabin amination). It is obtained in high yield after the hydrolysis of the intermediate salt (Merck, 2001; Shimizu et al., 1993).일반 설명
2-aminopyridine appears as white powder or crystals or light brown solid. It is soluble in water and alcohol. It is toxic by ingestion and by inhalation of the dust. It is used to make pharmaceuticals and dyes. (NTP, 1992)공기와 물의 반응
Decomposes in air. Soluble in water.반응 프로필
2-Aminopyridine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. Reacts with oxidizing agents .위험도
Toxic.건강위험
2-Aminopyridine causes central nervous system effects.화재위험
2-Aminopyridine is combustible.Safety Profile
Poison by ingestion, inhalation, subcutaneous, intravenous, and intraperitoneal routes. Toxic effects resemble strychnine poisoning. Human systemic effects by inhalation: somnolence, convulsions, and antipsychotic effects. Human central nervous system effects by inhalation. When heated to decomposition it emits highly toxic fumes of NOx,.잠재적 노출
2-Aminopyridine is used in the manufacture of pharmaceuticals; especially antihistamines.Carcinogenicity
The LD50 in mice by intraperitoneal injection was 35 mg/kg; lethal doses in animals also produced excitement, tremors, convulsions and tetany.1 Fatal doses were readily absorbed through the skin. A 0.2 M aqueous solution dropped in a rabbit’s eye was only mildly irritating.2-Aminopyridine was not mutagenic in a variety of Salmonella tester strains with or without metabolic activation.
환경귀착
Soil. When radio-labeled 4-aminopyridine was incubated in moist soils (50%) under aerobic conditions at 30 °C, the amount of 14CO2 released from an acidic loam (pH 4.1) and an alkaline, loamy sand (pH 7.8) was 0.4 and 50%, respectively (Starr and Cunningham, 1975).Chemical/Physical. Releases toxic nitrogen oxides when heated to decomposition (Sax and Lewis, 1987).
운송 방법
UN2671 Aminopyridines, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.Purification Methods
It crystallises from *benzene/pet ether (b 40-60o) or CHCl3 /pet ether. [Beilstein 22/8 V 280.]비 호환성
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides폐기물 처리
Incineration with nitrogen oxides removal from effluent gas.2-아미노피리딘 준비 용품 및 원자재
원자재
준비 용품
설파살라진
2,6-디아미노피리딘
2-Acetamido-5-fluoropyridine
1-(2-Pyridylazo)-2-naphthol
3-(2-Chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
피록시캄
2,5-Dibromo-3-nitropyridine
Tenoxicam
2-Benzylaminopyridine
2-Fluoropyridine-5-boronic acid
2-ACETAMIDO-5-AMINOPYRIDINE
2-메틸이미다조[1,2-A]피리딘-3-카르복실산
2-(5-브로모-2-피리딜라조)-5-(디에틸아미노)페놀
2-브로모피리딘
N-(3-FORMYL-2-PYRIDINYL)-2,2-DIMETHYLPROPANAMIDE
2-아미노-5-나이트로피리딘
2-Acetamido-5-nitropyridine
7-CHLORO-10-(4-HYDROXYANILINO)-2-METHOXY BENZO(B)-1,5-NAPHTHY RIDINE
이마조설푸론
Lornoxicam
이미다조[1,2-A]피리딘-2-CARBOXYLICACID
5-(AMINOMETHYL)PYRIDIN-2-AMINE
2-메틸-이미다조[1,2-A]피리딘-3-카르복실산에틸에스테르
2-Fluoro-5-iodopyridine
2-히드록시-5-니트로피리딘
설파피리딘
2-Chloro-5-nitropyridine
피리딘-2,3,6-트리아민
2-CHLORO-5-FLUOROISONICOTINIC ACID
IMIDAZO[1,2-A]피리딘-2-카르복실산에틸에스테르
2-Chloro-5-iodopyridine
2-클로로피리딘
2-아미노피리딘 공급 업체
글로벌( 641)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Shanghai UCHEM Inc. | +862156762820 +86-13564624040 |
sales@myuchem.com | China | 7192 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
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Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 |
sales@frappschem.com | China | 885 | 50 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21663 | 55 |
Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 |
jack.li@time-chemicals.com | China | 1807 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32836 | 60 |
Speranza Chemical Co., Ltd. | +86-86-075521030354 +8618688942810 |
sophieliu@speranzachem.com | China | 801 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Win-Win Chemical CO., Limited | 0086-577-64498589 |
sales@win-winchemical.com | CHINA | 998 | 58 |