2-브로모피리딘
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2-브로모피리딘 속성
- 녹는점
- 193°C
- 끓는 점
- 192-194 °C (lit.)
- 밀도
- 1.657 g/mL at 25 °C (lit.)
- 굴절률
- n
20/D 1.572(lit.)
- 인화점
- 130 °F
- 저장 조건
- Keep in dark place,Sealed in dry,Room Temperature
- 용해도
- 20g/L
- 물리적 상태
- 액체
- 산도 계수 (pKa)
- pK1: 0.71(+1) (25°C)
- 색상
- 무색투명~엷은 갈색
- 수용성
- 물과 약간 섞임.
- BRN
- 105789
- Dielectric constant
- 24.02
- 안정성
- 안정적인. 가연성. 강한 산화제, 강산, 산성 염화물과 호환되지 않습니다.
- InChIKey
- IMRWILPUOVGIMU-UHFFFAOYSA-N
- LogP
- 1.42
- CAS 데이터베이스
- 109-04-6(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T,Xn,F | ||
---|---|---|---|
위험 카페고리 넘버 | 10-24/25-36/37/38-23/24/25-20/21/22 | ||
안전지침서 | 16-36/37-45-38-36/37/39-28A-26 | ||
유엔번호(UN No.) | UN 2929 6.1/PG 2 | ||
WGK 독일 | 3 | ||
RTECS 번호 | US3850000 | ||
F 고인화성물질 | 8 | ||
위험 참고 사항 | Toxic | ||
TSCA | Yes | ||
위험 등급 | 6.1 | ||
포장분류 | II | ||
HS 번호 | 29333999 |
2-브로모피리딘 C화학적 특성, 용도, 생산
화학적 성질
light yellow oily or dark red liquid. miscible with ethanol, ether, benzene and pyridine, still soluble in water.용도
2-Bromopyridine is a 2-halogenated pyridine used in the preparation of a variety of biologically active compounds such as antimalarial agents and beta-adrenoceptor agonist.제조 방법
2-Bromopyridine is synthesized from 2-aminopyridine by bromination. In industrial production, hydrobromic acid (over 48%) is first cooled to below 0°C, 2-aminopyridine is slowly added, and then liquid bromine is added dropwise in a salt bath under freezing, and the rate of addition is to control the reaction temperature below -5°C appropriate. After adding, add sodium nitrite aqueous solution dropwise, control the reaction temperature to be below 0°C, stir for 20-30min, dropwise add 50% sodium hydroxide solution, extract the reaction solution with ether, wash with water, dry with anhydrous sodium sulfate, filter, and recover Diethyl ether, the residue was distilled under reduced pressure, and the 88°C-94°C/3333Pa fraction was collected to obtain the finished product of 2-bromopyridine with a yield of 83.8%.화학 반응
2-Bromopyridine reacts with butyllithium to give 2-lithiopyridine, which is a versatile reagent.Pyrithione can be prepared in a two-step synthesis from 2-bromopyridine by oxidation to the N-oxide with a suitable peracid followed by substitution using either sodium dithionite or sodium sulfide with sodium hydroxide to introduce the thiol functional group.Purification Methods
Dry 2-bromopyridine over KOH for several days, then distil it from CaO under reduced pressure, and taking the middle fraction. [Beilstein 20/5 V 422.]2-브로모피리딘 준비 용품 및 원자재
원자재
Liquid bromine
벤젠
브롬
2-아미노피리딘
2,3-Dibromopyridine
2-Bromo-3-methylpyridine
2,6-Dibromopyridine
2,5-Dibromopyridine
준비 용품
2-피리딘카르복스알데하이드
2-Hydrazinopyridine
DI-2-PYRIDYL KETONE
DISOPYRAMIDE
2-Iodopyridine
5-AMINO-2-METHOXY-3-PICOLINE
2-BROMO-3-FORMYLPYRIDINE
2-Pyridineboronic acid
5-METHYL-2-PYRIDIN-2-YL-2H-PYRAZOL-3-YLAMINE
2-아미노피리딘
1-pyridin-2-yl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid
2-(TRIFLUOROMETHYL)-4-ISOCYANATOPYRIDINE
3-PYRID-2-YLBENZOIC ACID
아타자나비어
2-Trifluoromethyl-6-pyridinecarboxylic acid
메틸-브이-부틸로락톤
2-Pyridylacetonitrile
2-브로모피리딘 공급 업체
글로벌( 637)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Shandong Believe Chemical PTE.LTD | +86-18553607090 +8618553607090 |
1093908296@qq.com | China | 1672 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12450 | 58 |
Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 |
daisy@crovellbio.com | China | 5828 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20294 | 58 |
Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 |
sales@frappschem.com | China | 885 | 50 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21668 | 55 |
Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 |
jack.li@time-chemicals.com | China | 1807 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9332 | 55 |
2-브로모피리딘 관련 검색:
피콜리네이트 크롬(III) 설파살라진 1-브로모-5-클로로펜탄 3-브로모피리딘 2,3-디아미노-5-브로모피리딘 2-브로모피리딘
1-Hexadecylpyridinium bromide
2-Bromo-4-pyridinecarboxaldehyde
Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
2-Chloro-3-cyanopyridine
Chloroiodomethane
Bromoacetonitrile
1-BROMOISOQUINOLIN-3-AMINE
2-Bromo-6-methoxypyridine
2-Bromo-5-nitropyridine
2-BROMO-4,6-DIMETHYLPYRIDINE
2-Bromo-3-trifluoromethylpyridine
Probucol