Mizoribine manufacturers and suppliers

Mizoribine suppliers

Properties

Melting point:: >2000C

alpha: D27 -35° (c = 0.8 in H2O)

Boiling point:: 402.47°C (rough estimate)

Density: 1.4155 (rough estimate)

refractive index: 1.5100 (estimate)

storage temp.: 2-8°C

solubility: DMSO (Slightly), Water (Slightly)

form: Solid

pka: 6.75(at 25℃)

color: White to Off-White

λmax: 280nm(lit.)

Merck: 14,6222

InChIKey: HZQDCMWJEBCWBR-UUOKFMHZSA-N

Safety Information

Symbol(GHS): GHS07,GHS08

Signal word: Danger

Hazard statements: H315-H319-H335-H360

Precautionary statements: P201-P302+P352-P305+P351+P338-P308+P313

Hazard Codes: T

Risk Statements: 46-60-61-36/37/38

Safety Statements: 53-22-26-36/37/39-45

WGK Germany: 3

RTECS: NI3980000

HS Code: 29349990

Toxicity: LD50 in mice (g/kg): >1.5 i.v., >2.4 i.p. (Mizuno, 1975)

Use

Mizoribine is a kind of imidazole nucleoside isolated from the culture medium of ascomycetes M-2166 separated from the soil by Japanese scholars Asahi Kasei, being the metabolite which inhibiting the purine synthesis pathway of nucleic acid, mainly being used for inhibiting the rejection reaction before or after renal transplantation and also used for liver transplantation and autoimmune diseases. Mizoribine, as a kind of immunosuppressant, its immunosuppressive effects may be related to its inhibition of purine nucleotide synthesis and increased transcriptional activity of the glucocorticoid receptor. It has been applied at Japanese clinical renal transplantation since December 1991. Many Japanese clinical transplant centers have applied mizoribine as the routine immunization inhibitory drug after kidney transplantation. In recent year, China has also applied kidney transplant anti-rejection drugs for clinical purpose. Mizoribine, compared with similar drugs azathioprine, has a low liver toxicity and bone marrow suppression effect with its main adverse reaction being the gastrointestinal reactions, blood disorders and allergic symptoms, and occasionally bone marrow suppression and acute renal failure.

You can find Mizoribine suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.