Sotalol manufacturers and suppliers

Sotalol suppliers

Sotalol

CAS:: 3930-20-9

MF:: C12H20N2O3S

MW:: 272.36

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Properties

Melting point:: 206.5-207 °C

Boiling point:: 443.3±55.0 °C(Predicted)

Density: 1.298 g/cm3

storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere

solubility: Chloroform (Slightly, Heated), Methanol (Slightly, Sonicated)

form: Solid

pka: pK1 8.2, pK2 9.8(at 25℃)

color: Pale Yellow to Light Yellow

BCS Class: 1

Stability:: Hygroscopic

InChI: InChI=1S/C12H20N2O3S/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17/h4-7,9,12-15H,8H2,1-3H3

InChIKey: ZBMZVLHSJCTVON-UHFFFAOYSA-N

SMILES: CS(NC1=CC=C(C(O)CNC(C)C)C=C1)(=O)=O

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H319

Precautionary statements: P305+P351+P338

Hazard Codes: Xi

Risk Statements: 36/37/38

Safety Statements: 26-36

Use

The sotalol enantiomers produce different effects onthe heart. Class III action of d-sotalol in the sinus node isassociated with slowing of sinus heart rate, whereas -adrenergicblockade contributes to the decrease in heart rate observedwith 1- or d,1-sotalol. Sotalol is not metabolized, noris it bound significantly to proteins. Elimination occurs byrenal excretion, with more than 80% of the drug eliminatedunchanged. Sotalol is characteristic of class III antiarrhythmicdrugs, in that it prolongs the duration of the action potentialand, thus, increases the effective refractory period of myocardialtissue. It is distinguished from the other class III drugs(amiodarone and bretylium) because of its -adrenergicreceptor–blocking action.

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