4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl-
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- $32 - $1900
- Product name: 4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl-
- CAS: 1197300-24-5
- MF: C18H14Cl2N2O2
- MW: 361.22
- EINECS:200-256-5
- MDL Number:MFCD17169972
- Synonyms:4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl-;TGR5;3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl-4-IsoxazolecarboxaMide;TGR5 Receptor Agonist;3-(2-CHLOROPHENYL)-N-(4-CHLOROPHENYL)-N,5-DIMETHYLISOXAZOLE-4-CARBOXAMIDE;3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethyl-4-isoxazolecarboxamide TGR5;TGR5 4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl-;TGR5 Receptor Agonist, >=98%
26 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Usbiological
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number3651DF
- Product descriptionTGR5ReceptorAgonist
- Packaging25mg
- Price$606
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA672110
- Product descriptionTGR5ReceptorAgonist 98+%
- Packaging5mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA672110
- Product descriptionTGR5ReceptorAgonist 98+%
- Packaging10mg
- Price$224
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA672110
- Product descriptionTGR5ReceptorAgonist 98+%
- Packaging25mg
- Price$404
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA672110
- Product descriptionTGR5ReceptorAgonist 98+%
- Packaging100mg
- Price$1086
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberHCH0316474
- Product description3-(2-CHLOROPHENYL)-N-(4-CHLOROPHENYL)-N,5-DIMETHYL-4-ISOXAZOLE CARBOXAMIDE 95.00%
- Packaging5MG
- Price$502.02
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1185
- Product descriptionTGR5ReceptorAgonist
- Packaging5mg
- Price$173
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1185
- Product descriptionTGR5ReceptorAgonist
- Packaging10mg
- Price$292
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1185
- Product descriptionTGR5ReceptorAgonist
- Packaging50mg
- Price$1008
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1185
- Product descriptionTGR5ReceptorAgonist
- Packaging100mg
- Price$1733
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16291
- Product descriptionTGR5 Receptor Agonist ≥98%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16291
- Product descriptionTGR5 Receptor Agonist ≥98%
- Packaging5mg
- Price$122
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16291
- Product descriptionTGR5 Receptor Agonist ≥98%
- Packaging10mg
- Price$214
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16291
- Product descriptionTGR5 Receptor Agonist ≥98%
- Packaging25mg
- Price$456
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM191456
- Product description3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethylisoxazole-4-carboxamide 98%
- Packaging10mg
- Price$274
- Updated2021-12-16
- Buy
- ManufacturerChemenu
- Product numberCM191456
- Product description3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethylisoxazole-4-carboxamide 98%
- Packaging50mg
- Price$730
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3651DF | TGR5ReceptorAgonist | 25mg | $606 | 2021-12-16 | Buy |
| Ambeed | A672110 | TGR5ReceptorAgonist 98+% | 5mg | $150 | 2021-12-16 | Buy |
| Ambeed | A672110 | TGR5ReceptorAgonist 98+% | 10mg | $224 | 2021-12-16 | Buy |
| Ambeed | A672110 | TGR5ReceptorAgonist 98+% | 25mg | $404 | 2021-12-16 | Buy |
| Ambeed | A672110 | TGR5ReceptorAgonist 98+% | 100mg | $1086 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0316474 | 3-(2-CHLOROPHENYL)-N-(4-CHLOROPHENYL)-N,5-DIMETHYL-4-ISOXAZOLE CARBOXAMIDE 95.00% | 5MG | $502.02 | 2021-12-16 | Buy |
| ApexBio Technology | B1185 | TGR5ReceptorAgonist | 5mg | $173 | 2021-12-16 | Buy |
| ApexBio Technology | B1185 | TGR5ReceptorAgonist | 10mg | $292 | 2021-12-16 | Buy |
| ApexBio Technology | B1185 | TGR5ReceptorAgonist | 50mg | $1008 | 2021-12-16 | Buy |
| ApexBio Technology | B1185 | TGR5ReceptorAgonist | 100mg | $1733 | 2021-12-16 | Buy |
| Cayman Chemical | 16291 | TGR5 Receptor Agonist ≥98% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 16291 | TGR5 Receptor Agonist ≥98% | 5mg | $122 | 2024-03-01 | Buy |
| Cayman Chemical | 16291 | TGR5 Receptor Agonist ≥98% | 10mg | $214 | 2024-03-01 | Buy |
| Cayman Chemical | 16291 | TGR5 Receptor Agonist ≥98% | 25mg | $456 | 2024-03-01 | Buy |
| Chemenu | CM191456 | 3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethylisoxazole-4-carboxamide 98% | 10mg | $274 | 2021-12-16 | Buy |
| Chemenu | CM191456 | 3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethylisoxazole-4-carboxamide 98% | 50mg | $730 | 2021-12-16 | Buy |
Properties
Boiling point :541.8±50.0 °C(Predicted)
Density :1.346±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml; Ethanol: 30 mg/ml
form :A crystalline solid
pka :-0.52±0.50(Predicted)
color :White to off-white
Density :1.346±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml; Ethanol: 30 mg/ml
form :A crystalline solid
pka :-0.52±0.50(Predicted)
color :White to off-white
Safety Information
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Description
TGR5 is a G protein-coupled receptor for bile acids that mediates energy balance, inflammation, and digestion. TGR5 Receptor Agonist is a synthetic small molecule activator of this bile acid receptor (pEC50 = 6.8-7.5) that is reported to improve glucagon-like peptide-1 (GLP-1) secretion by increasing intracellular cAMP levels via TGR5. In a canine model, 1 mg/kg of this TGR5 receptor agonist co-administered with glucose has been shown to increase GLP-1 secretion, improving glucose disposal. This compound potently stimulates cAMP formation (EC50 = 2.3 pM) in HEK cells expressing TGR5, and has been used to investigate the signaling, trafficking, and regulation of TGR5 receptors in order to identify potentially useful therapeutics for metabolic disorders.Suppliers and manufacturers
career henan chemical co
ATK CHEMICAL COMPANY LIMITED
TargetMol Chemicals Inc.
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
ShenZhen Trendseen Biological Technology Co.,Ltd.
Aladdin Scientific
Amadis Chemical Company Limited
Shanghai Boyle Chemical Co., Ltd.
$5.00 /5KG
4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl- CAS:1197300-24-5
4-IsoxazolecarboxaMide, 3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diMethyl- CAS:1197300-24-5