N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
- $32 - $4725
- Product name: N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
- CAS: 315703-52-7
- MF: C19H18N4OS
- MW: 350.44
- EINECS:
- MDL Number:MFCD01044465
- Synonyms:N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine;Hh Signaling Antagonist VII, JK184;JK 184;N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine;2-ThiazolaMine, N-(4-ethoxyphenyl)-4-(2-MethyliMidazo[1,2-a]pyridin-3-yl)-;Hh Signaling Antagonist VII, JK184 - CAS 315703-52-7 - Calbiochem;CS-2369;JK184 (JK-184
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Brand
- AK Scientific
- ApexBio Technology
- Axon Medchem
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 25
- 50mg
- 100mg
- 250mg
- 5
- 1g
- ManufacturerAK Scientific
- Product number3425AB
- Product descriptionN-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
- Packaging1g
- Price$1246
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number3425AB
- Product descriptionN-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
- Packaging25mg
- Price$263
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number3425AB
- Product descriptionN-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
- Packaging5mg
- Price$113
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8652
- Product descriptionJK184
- Packaging5mg
- Price$87
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8652
- Product descriptionJK184
- Packaging10mg
- Price$127
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8652
- Product descriptionJK184
- Packaging50mg
- Price$554
- Updated2021-12-16
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- ManufacturerApexBio Technology
- Product numberA8652
- Product descriptionJK184
- Packaging100mg
- Price$992
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2654
- Product descriptionJK184 100%
- Packaging50mg
- Price$308
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number15265
- Product descriptionJK 184 ≥99%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15265
- Product descriptionJK 184 ≥99%
- Packaging5mg
- Price$62
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15265
- Product descriptionJK 184 ≥99%
- Packaging10mg
- Price$109
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15265
- Product descriptionJK 184 ≥99%
- Packaging50mg
- Price$472
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM175661
- Product descriptionN-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine 95%
- Packaging100mg
- Price$386
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6080
- Product descriptionJK184 99.95%
- Packaging5mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6080
- Product descriptionJK184 99.95%
- Packaging10mg
- Price$96
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6080
- Product descriptionJK184 99.95%
- Packaging50mg
- Price$396
- Updated2021-12-16
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
AK Scientific | 3425AB | N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine | 1g | $1246 | 2021-12-16 | Buy |
AK Scientific | 3425AB | N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine | 25mg | $263 | 2021-12-16 | Buy |
AK Scientific | 3425AB | N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine | 5mg | $113 | 2021-12-16 | Buy |
ApexBio Technology | A8652 | JK184 | 5mg | $87 | 2021-12-16 | Buy |
ApexBio Technology | A8652 | JK184 | 10mg | $127 | 2021-12-16 | Buy |
ApexBio Technology | A8652 | JK184 | 50mg | $554 | 2021-12-16 | Buy |
ApexBio Technology | A8652 | JK184 | 100mg | $992 | 2021-12-16 | Buy |
Axon Medchem | Axon2654 | JK184 100% | 50mg | $308 | 2021-12-16 | Buy |
Cayman Chemical | 15265 | JK 184 ≥99% | 1mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 15265 | JK 184 ≥99% | 5mg | $62 | 2024-03-01 | Buy |
Cayman Chemical | 15265 | JK 184 ≥99% | 10mg | $109 | 2024-03-01 | Buy |
Cayman Chemical | 15265 | JK 184 ≥99% | 50mg | $472 | 2024-03-01 | Buy |
Chemenu | CM175661 | N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine 95% | 100mg | $386 | 2021-12-16 | Buy |
ChemScene | CS-6080 | JK184 99.95% | 5mg | $60 | 2021-12-16 | Buy |
ChemScene | CS-6080 | JK184 99.95% | 10mg | $96 | 2021-12-16 | Buy |
ChemScene | CS-6080 | JK184 99.95% | 50mg | $396 | 2021-12-16 | Buy |
Properties
storage temp. :Keep in dark place,Inert atmosphere,2-8°C
solubility :DMSO: ≥20mg/mL
form :powder
color :off-white to light brown
solubility :DMSO: ≥20mg/mL
form :powder
color :off-white to light brown
Safety Information
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Signal word: | Danger | |||||||||||||||||||||
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Description
JK 184 is an imidazopyridine derivative that inhibits downstream hedgehog signaling, preventing Gli-dependent transcriptional activity (IC50 = 30 nM). It does so by inhibiting alcohol dehydrogenase 7 (IC50 = 210 nM) and depolymerizing microtubules, preventing their assembly, which is crucial for Gli function. JK 184 exhibits antiproliferative activity in a range of cancer cell lines (L3.6pl, Panc 05.04, BxPC3, D283 med, Daoy; GI50s = 3-21 nM) and in L3.6pl and BxPC3 pancreatic cancer xenograft models (0.2 mg/mouse/day).Related product price
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