Insulin-like Growth Factor-1 Receptor Inhibitor
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- $49 - $14000
- Product name: Insulin-like Growth Factor-1 Receptor Inhibitor
- CAS: 468740-43-4
- MF: C25H26ClN5O3
- MW: 479.96
- EINECS:
- MDL Number:MFCD14635360
- Synonyms:4-[[(2S)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]-3-[7-methyl-5-(4-morpholinyl)-1H-benzimidazol-2-yl]-2(1H)-pyridinone;BMS-536924;Insulin-like Growth Factor-1 Receptor Inhibitor;4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-[4-methyl-6-(4-morpholinyl)-1H-benzimidazol-2-yl]- 2(1H)-pyridinone;CS-0117;HY-10262;BMS-536924 Insulin-like Growth Factor-1 Receptor Inhibitor;BMS-536924, >=98%
25 prices
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Brand
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Labseeker
- Tocris
- TRC
- Usbiological
Package
- 1mg
- 5MG
- 10mg
- 25mg
- 50mg
- 10
- 10mM(in 1mL DMSO)
- 100mg
- 250mg
- 1g
- 10G
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000061
- Product descriptionBMS-536924 95.00%
- Packaging5MG
- Price$330
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000061
- Product descriptionBMS-536924 95.00%
- Packaging10G
- Price$2619.54
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA2238
- Product description(3E)-4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-(4-methyl-6-morpholin-4-yl-1,3-dihydrobenzimidazol-2-ylidene)pyridin-2-one
- Packaging5mg
- Price$149
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA2238
- Product description(3E)-4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-(4-methyl-6-morpholin-4-yl-1,3-dihydrobenzimidazol-2-ylidene)pyridin-2-one
- Packaging10mM(in 1mL DMSO)
- Price$163
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA2238
- Product description(3E)-4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-(4-methyl-6-morpholin-4-yl-1,3-dihydrobenzimidazol-2-ylidene)pyridin-2-one
- Packaging10mg
- Price$263
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA2238
- Product description(3E)-4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-(4-methyl-6-morpholin-4-yl-1,3-dihydrobenzimidazol-2-ylidene)pyridin-2-one
- Packaging50mg
- Price$1004
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60344
- Product descriptionBMS-536924
- Packaging10mg
- Price$308
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180753
- Product descriptionBMS-536924 >98%
- Packaging100mg
- Price$838.1
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180753
- Product descriptionBMS-536924 >98%
- Packaging250mg
- Price$1654.1
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180753
- Product descriptionBMS-536924 >98%
- Packaging1g
- Price$3432.3
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number14666
- Product descriptionBMS-536924 ≥98%
- Packaging1mg
- Price$49
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14666
- Product descriptionBMS-536924 ≥98%
- Packaging5mg
- Price$190
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14666
- Product descriptionBMS-536924 ≥98%
- Packaging10mg
- Price$286
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14666
- Product descriptionBMS-536924 ≥98%
- Packaging25mg
- Price$651
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0117
- Product descriptionBMS-536924 99.74%
- Packaging5mg
- Price$162
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0117
- Product descriptionBMS-536924 99.74%
- Packaging10mg
- Price$302
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | KIN0000061 | BMS-536924 95.00% | 5MG | $330 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000061 | BMS-536924 95.00% | 10G | $2619.54 | 2021-12-16 | Buy |
| ApexBio Technology | A2238 | (3E)-4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-(4-methyl-6-morpholin-4-yl-1,3-dihydrobenzimidazol-2-ylidene)pyridin-2-one | 5mg | $149 | 2021-12-16 | Buy |
| ApexBio Technology | A2238 | (3E)-4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-(4-methyl-6-morpholin-4-yl-1,3-dihydrobenzimidazol-2-ylidene)pyridin-2-one | 10mM(in 1mL DMSO) | $163 | 2021-12-16 | Buy |
| ApexBio Technology | A2238 | (3E)-4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-(4-methyl-6-morpholin-4-yl-1,3-dihydrobenzimidazol-2-ylidene)pyridin-2-one | 10mg | $263 | 2021-12-16 | Buy |
| ApexBio Technology | A2238 | (3E)-4-[[(2S)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]-3-(4-methyl-6-morpholin-4-yl-1,3-dihydrobenzimidazol-2-ylidene)pyridin-2-one | 50mg | $1004 | 2021-12-16 | Buy |
| Arctom | CFN60344 | BMS-536924 | 10mg | $308 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180753 | BMS-536924 >98% | 100mg | $838.1 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180753 | BMS-536924 >98% | 250mg | $1654.1 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180753 | BMS-536924 >98% | 1g | $3432.3 | 2021-12-16 | Buy |
| Cayman Chemical | 14666 | BMS-536924 ≥98% | 1mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 14666 | BMS-536924 ≥98% | 5mg | $190 | 2024-03-01 | Buy |
| Cayman Chemical | 14666 | BMS-536924 ≥98% | 10mg | $286 | 2024-03-01 | Buy |
| Cayman Chemical | 14666 | BMS-536924 ≥98% | 25mg | $651 | 2024-03-01 | Buy |
| ChemScene | CS-0117 | BMS-536924 99.74% | 5mg | $162 | 2021-12-16 | Buy |
| ChemScene | CS-0117 | BMS-536924 99.74% | 10mg | $302 | 2021-12-16 | Buy |
Properties
Melting point :>206°C (dec.)
Density :1.44
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :DMSO (Slightly)
pka :10.40±0.10(Predicted)
form :Solid
color :Light Yellow to Yellow
CAS DataBase Reference :468740-43-4
Density :1.44
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :DMSO (Slightly)
pka :10.40±0.10(Predicted)
form :Solid
color :Light Yellow to Yellow
CAS DataBase Reference :468740-43-4
Safety Information
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Description
BMS-536924 is a dual inhibitor of insulin-like growth factor receptor (IGF1R) kinase and insulin receptor (IC50s = 100 and 73 nM, respectively). In this way, it blocks IGF1R autophosphorylation and signaling through MEK1/2 and Akt, leading to G1 arrest and apoptosis in myeloblastic leukemia ML-1 cells. BMS-536924 reverses epithelial-to-mesenchymal transition in immortalized mammary epithelial MCF10A cells overexpressing constitutively activated IGF1R and causes growth inhibition and polarization of breast cancer MCF-7 cells. It also induces expression of cytochrome P450 3A4 isoform in primary hepatocytes.Related product price
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