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ChemicalBook >> CAS DataBase List >> N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide

N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide

N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide price.
  • $20 - $1110
  • Product name: N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide
  • CAS: 53501-41-0
  • MF: C14H10ClN3O4S
  • MW: 351.76
  • EINECS:
  • MDL Number:MFCD00761149
  • Synonyms:N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide;PIT 1;Benzamide, N-[[(3-chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]-;N-((3-Chloro-2-hydroxy-5-nitrophenyl)carbamothioyl)benzamide
14 prices
Selected condition:
Brand
  • AK Scientific
  • ApexBio Technology
  • Cayman Chemical
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 50
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 10
  • 100mg
  • ManufacturerAK Scientific
  • Product number8518CK
  • Product descriptionN-[(3-Chloro-2-hydroxy-5-nitrophenyl)carbamothioyl]benzamide
  • Packaging5mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7601
  • Product descriptionPIT1
  • Packaging10mg
  • Price$266
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7601
  • Product descriptionPIT1
  • Packaging50mg
  • Price$1110
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number10728
  • Product descriptionPIT-1 ≥98%
  • Packaging5mg
  • Price$20
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10728
  • Product descriptionPIT-1 ≥98%
  • Packaging10mg
  • Price$37
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10728
  • Product descriptionPIT-1 ≥98%
  • Packaging50mg
  • Price$146
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10728
  • Product descriptionPIT-1 ≥98%
  • Packaging100mg
  • Price$257
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML0122
  • Product descriptionPit-1 ≥98% (HPLC)
  • Packaging5mg
  • Price$97.9
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML0122
  • Product descriptionPit-1 ≥98% (HPLC)
  • Packaging25mg
  • Price$388
  • Updated2024-03-01
  • Buy
  • ManufacturerTocris
  • Product number4168
  • Product descriptionPIT1 ≥99%(HPLC)
  • Packaging10
  • Price$157
  • Updated2021-12-16
  • Buy
  • ManufacturerTocris
  • Product number4168
  • Product descriptionPIT1 ≥99%(HPLC)
  • Packaging50
  • Price$648
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberP475258
  • Product descriptionPIT1
  • Packaging25mg
  • Price$240
  • Updated2021-12-16
  • Buy
  • ManufacturerUsbiological
  • Product number462711
  • Product descriptionPIT 1
  • Packaging10mg
  • Price$403
  • Updated2021-12-16
  • Buy
  • ManufacturerUsbiological
  • Product number256267
  • Product descriptionPIT 1
  • Packaging10mg
  • Price$418
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 8518CK N-[(3-Chloro-2-hydroxy-5-nitrophenyl)carbamothioyl]benzamide 5mg $120 2021-12-16 Buy
ApexBio Technology B7601 PIT1 10mg $266 2021-12-16 Buy
ApexBio Technology B7601 PIT1 50mg $1110 2021-12-16 Buy
Cayman Chemical 10728 PIT-1 ≥98% 5mg $20 2024-03-01 Buy
Cayman Chemical 10728 PIT-1 ≥98% 10mg $37 2024-03-01 Buy
Cayman Chemical 10728 PIT-1 ≥98% 50mg $146 2024-03-01 Buy
Cayman Chemical 10728 PIT-1 ≥98% 100mg $257 2024-03-01 Buy
Sigma-Aldrich SML0122 Pit-1 ≥98% (HPLC) 5mg $97.9 2024-03-01 Buy
Sigma-Aldrich SML0122 Pit-1 ≥98% (HPLC) 25mg $388 2024-03-01 Buy
Tocris 4168 PIT1 ≥99%(HPLC) 10 $157 2021-12-16 Buy
Tocris 4168 PIT1 ≥99%(HPLC) 50 $648 2021-12-16 Buy
TRC P475258 PIT1 25mg $240 2021-12-16 Buy
Usbiological 462711 PIT 1 10mg $403 2021-12-16 Buy
Usbiological 256267 PIT 1 10mg $418 2021-12-16 Buy

Properties

Density :1.592
storage temp. :Store at +4°C
solubility :DMSO: ≥14mg/mL
form :powder
pka :4.44±0.50(Predicted)
color :white to tan
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P273 Avoid release to the environment.

Description

PtdIns-(3,4,5)-P3 (PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN. Protein binding to PIP3 is important for cytoskeletal rearrangement and membrane trafficking and initiates an intricate signaling cascade that has been implicated in cancer. PIT-1 is a selective nonphosphoinositide inhibitor that specifically disrupts PIP3/Akt PH domain binding with an IC50 value of 31 μM. PIT-1 suppresses PI3K-PDK1-Akt-dependent phosphorylation, which has been shown to reduce cell viability and induce apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 μM).

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