8-(1H-IMIDAZOL-4-YLMETHYLENE)-6,8-DIHYDRO-THIAZOLO[5,4-E]INDOL-7-ONE
![8-(1H-IMIDAZOL-4-YLMETHYLENE)-6,8-DIHYDRO-THIAZOLO[5,4-E]INDOL-7-ONE price.](/CAS/GIF/608512-97-6.gif)
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- $32 - $2046
- Product name: 8-(1H-IMIDAZOL-4-YLMETHYLENE)-6,8-DIHYDRO-THIAZOLO[5,4-E]INDOL-7-ONE
- CAS: 608512-97-6
- MF: C13H8N4OS
- MW: 268.29
- EINECS:
- MDL Number:MFCD06735404
- Synonyms:8-(1H-IMIDAZOL-4-YLMETHYLENE)-6,8-DIHYDRO-THIAZOLO[5,4-E]INDOL-7-ONE;PKR INHIBITOR;6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one;Imidazolo-oxindole PKR inhibitor C16;GW 506033X;(Z)-8-((1H-Imidazol-4-yl)methylene)-6H-thiazolo[5,4-e]indol-7(8H)-one;InSolution? PKR Inhibitor ;PKR Inhibitor - CAS 608512-97-6 - Calbiochem
23 prices
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Brand
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
Package
- 1MG
- 5mg
- 10mg
- 25MG
- 100mg
- 250mg
- 1g
- ManufacturerAmbeed
- Product numberA1209816
- Product description8-((1H-Imidazol-4-yl)methylene)-6,8-dihydro-7H-thiazolo[5,4-e]indol-7-one 98+%
- Packaging5mg
- Price$78
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA1209816
- Product description8-((1H-Imidazol-4-yl)methylene)-6,8-dihydro-7H-thiazolo[5,4-e]indol-7-one 98+%
- Packaging10mg
- Price$117
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA1209816
- Product description8-((1H-Imidazol-4-yl)methylene)-6,8-dihydro-7H-thiazolo[5,4-e]indol-7-one 98+%
- Packaging100mg
- Price$568
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA1209816
- Product description8-((1H-Imidazol-4-yl)methylene)-6,8-dihydro-7H-thiazolo[5,4-e]indol-7-one 98+%
- Packaging250mg
- Price$867
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA1209816
- Product description8-((1H-Imidazol-4-yl)methylene)-6,8-dihydro-7H-thiazolo[5,4-e]indol-7-one 98+%
- Packaging1g
- Price$2046
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000810
- Product descriptionIMIDAZOLO-OXINDOLE PKR INHIBITOR C16 95.00%
- Packaging1MG
- Price$135.45
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000810
- Product descriptionIMIDAZOLO-OXINDOLE PKR INHIBITOR C16 95.00%
- Packaging5MG
- Price$649.35
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000810
- Product descriptionIMIDAZOLO-OXINDOLE PKR INHIBITOR C16 95.00%
- Packaging25MG
- Price$842.26
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4439
- Product descriptionPKR Inhibitor
- Packaging5mg
- Price$88
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4439
- Product descriptionPKR Inhibitor
- Packaging10mg
- Price$158
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC4439
- Product descriptionPKR Inhibitor
- Packaging25mg
- Price$347
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number15323
- Product descriptionPKR Inhibitor ≥95%
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15323
- Product descriptionPKR Inhibitor ≥95%
- Packaging5mg
- Price$78
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15323
- Product descriptionPKR Inhibitor ≥95%
- Packaging10mg
- Price$139
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number15323
- Product descriptionPKR Inhibitor ≥95%
- Packaging25mg
- Price$305
- Updated2024-03-01
- Buy
- ManufacturerDC Chemicals
- Product numberDC33146
- Product descriptionGW-506033X(PKRInhibitorC16)
- Packaging100mg
- Price$550
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Ambeed | A1209816 | 8-((1H-Imidazol-4-yl)methylene)-6,8-dihydro-7H-thiazolo[5,4-e]indol-7-one 98+% | 5mg | $78 | 2021-12-16 | Buy |
| Ambeed | A1209816 | 8-((1H-Imidazol-4-yl)methylene)-6,8-dihydro-7H-thiazolo[5,4-e]indol-7-one 98+% | 10mg | $117 | 2021-12-16 | Buy |
| Ambeed | A1209816 | 8-((1H-Imidazol-4-yl)methylene)-6,8-dihydro-7H-thiazolo[5,4-e]indol-7-one 98+% | 100mg | $568 | 2021-12-16 | Buy |
| Ambeed | A1209816 | 8-((1H-Imidazol-4-yl)methylene)-6,8-dihydro-7H-thiazolo[5,4-e]indol-7-one 98+% | 250mg | $867 | 2021-12-16 | Buy |
| Ambeed | A1209816 | 8-((1H-Imidazol-4-yl)methylene)-6,8-dihydro-7H-thiazolo[5,4-e]indol-7-one 98+% | 1g | $2046 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000810 | IMIDAZOLO-OXINDOLE PKR INHIBITOR C16 95.00% | 1MG | $135.45 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000810 | IMIDAZOLO-OXINDOLE PKR INHIBITOR C16 95.00% | 5MG | $649.35 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000810 | IMIDAZOLO-OXINDOLE PKR INHIBITOR C16 95.00% | 25MG | $842.26 | 2021-12-16 | Buy |
| ApexBio Technology | C4439 | PKR Inhibitor | 5mg | $88 | 2021-12-16 | Buy |
| ApexBio Technology | C4439 | PKR Inhibitor | 10mg | $158 | 2021-12-16 | Buy |
| ApexBio Technology | C4439 | PKR Inhibitor | 25mg | $347 | 2021-12-16 | Buy |
| Cayman Chemical | 15323 | PKR Inhibitor ≥95% | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 15323 | PKR Inhibitor ≥95% | 5mg | $78 | 2024-03-01 | Buy |
| Cayman Chemical | 15323 | PKR Inhibitor ≥95% | 10mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 15323 | PKR Inhibitor ≥95% | 25mg | $305 | 2024-03-01 | Buy |
| DC Chemicals | DC33146 | GW-506033X(PKRInhibitorC16) | 100mg | $550 | 2021-12-16 | Buy |
Properties
Boiling point :674.6±55.0 °C(Predicted)
Density :1.604±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble12mg/mL
pka :10.20±0.20(Predicted)
form :Orange to orange brown solid
color :yellow to orange-brown
Stability :Stable for 2 years from date of purchsae as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Density :1.604±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble12mg/mL
pka :10.20±0.20(Predicted)
form :Orange to orange brown solid
color :yellow to orange-brown
Stability :Stable for 2 years from date of purchsae as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Safety Information
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Description
The activity of double-stranded RNA-activated protein kinase (PKR) is altered by viral infection as well as by various neuropathologies. A primary phosphorylation target of PKR is eukaryotic initiation factor 2 subunit α (eIF2α), blocking translation and driving apoptosis. PKR Inhibitor is an oxindole/imidazole derivative that binds the ATP-binding site of PKR and blocks autophosphorylation with an IC50 value of 186-210 nM. PKR Inhibitor protects human neuroblastoma cells against cell damage triggered by tunicamycin-mediated endoplasmic reticulum stress. It also prevents phosphorylation of Fas-associated protein with a death domain (FADD) in neuroblastoma cells, preventing FADD-dependent activation of caspases and apoptosis. Intraperitoneal administration of PKR inhibitor in rats reduces phosphorylation of PKR and eIF2α in the brain. Similar administration in mice enhances long-term memory storage, including contextual and auditory long-term fear memories.Related product price
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![8-(1H-IMIDAZOL-4-YLMETHYLENE)-6,8-DIHYDRO-THIAZOLO[5,4-E]INDOL-7-ONE](https://img.chemicalbook.com/ProductImageEN/2019-12/small/c8e99c4c-c412-4599-8b63-00e0c8736d86.jpg){kind=small}