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ChemicalBook >> CAS DataBase List >> 3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE

3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE

3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE price.
  • $32 - $1758.49
  • Product name: 3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE
  • CAS: 622387-85-3
  • MF: C18H15N3O3S
  • MW: 353.39
  • EINECS:
  • MDL Number:MFCD07776820
  • Synonyms:Syk Inhibitor;3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE;OXSI 2;2,3-Dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-1H-indole-5-sulfonamide;3-[(1-METHYLINDOL-3-YL)METHYLIDENE]-2-OXO-1H-INDOLE-5-SULFONAMIDE;1H-Indole-5-sulfonamide, 2,3-dihydro-3-[(1-methyl-1H-indol-3-yl)methylene]-2-oxo-;Inhibitor,Tyrosine,OXSI-2,Potassium,Inflammasome,PAR,Pyroptosis,Src,kinase,Piceatannol,Syk,OXSI2,Spleen tyrosine kinase,inhibit,signaling,GPVI,Inflammation
Price13 Properties Safety Information Description
13 prices
Selected condition：
Brand
  • aablocks
  • AK Scientific
  • Alfa Aesar
  • American Custom Chemicals Corporation
  • Cayman Chemical
  • Sigma-Aldrich
  • Tocris
  • TRC
Package
  • 50
  • 500μg
  • 1mg
  • 5mg
  • 10mg
  • 10
  • 1G
  • Manufactureraablocks
  • Product numberAA00ED5S
  • Product description3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONICACIDAMIDE ≥95%(mixtureofisomers)
  • Packaging1mg
  • Price$104
  • Updated2021-12-16
  • Buy
  • Manufactureraablocks
  • Product numberAA00ED5S
  • Product description3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONICACIDAMIDE ≥95%(mixtureofisomers)
  • Packaging10mg
  • Price$238
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2195DC
  • Product description3-[(1-Methyl-3-indolyl)methylidene]-2-oxo-1H-indole-5-sulfonamide
  • Packaging1mg
  • Price$158
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ64281
  • Product descriptionSyk Inhibitor
  • Packaging1mg
  • Price$50.3
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ64281
  • Product descriptionSyk Inhibitor
  • Packaging5mg
  • Price$190
  • Updated2023-06-20
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberCHM0022089
  • Product description3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE 95.00%
  • Packaging1G
  • Price$1758.49
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number14829
  • Product descriptionSyk Inhibitor ≥95% (mixture of isomers)
  • Packaging500μg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14829
  • Product descriptionSyk Inhibitor ≥95% (mixture of isomers)
  • Packaging1mg
  • Price$55
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14829
  • Product descriptionSyk Inhibitor ≥95% (mixture of isomers)
  • Packaging10mg
  • Price$184
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number574711
  • Product descriptionSyk Inhibitor - CAS 622387-85-3 - Calbiochem
  • Packaging5mg
  • Price$187
  • Updated2024-03-01
  • Buy
  • ManufacturerTocris
  • Product number6012
  • Product descriptionOXSI2 ≥98%(HPLC)
  • Packaging10
  • Price$185
  • Updated2021-12-16
  • Buy
  • ManufacturerTocris
  • Product number6012
  • Product descriptionOXSI2 ≥98%(HPLC)
  • Packaging50
  • Price$774
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberO990038
  • Product descriptionOXSI2
  • Packaging1mg
  • Price$105
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00ED5S 3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONICACIDAMIDE ≥95%(mixtureofisomers) 1mg $104 2021-12-16 Buy
aablocks AA00ED5S 3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONICACIDAMIDE ≥95%(mixtureofisomers) 10mg $238 2021-12-16 Buy
AK Scientific 2195DC 3-[(1-Methyl-3-indolyl)methylidene]-2-oxo-1H-indole-5-sulfonamide 1mg $158 2021-12-16 Buy
Alfa Aesar J64281 Syk Inhibitor 1mg $50.3 2021-12-16 Buy
Alfa Aesar J64281 Syk Inhibitor 5mg $190 2023-06-20 Buy
American Custom Chemicals Corporation CHM0022089 3-(1-METHYLINDOL-3-YLMETHYLENE)-2-OXO-2,3-DIHYDROINDOLE-5-SULFONIC ACID AMIDE 95.00% 1G $1758.49 2021-12-16 Buy
Cayman Chemical 14829 Syk Inhibitor ≥95% (mixture of isomers) 500μg $32 2024-03-01 Buy
Cayman Chemical 14829 Syk Inhibitor ≥95% (mixture of isomers) 1mg $55 2024-03-01 Buy
Cayman Chemical 14829 Syk Inhibitor ≥95% (mixture of isomers) 10mg $184 2024-03-01 Buy
Sigma-Aldrich 574711 Syk Inhibitor - CAS 622387-85-3 - Calbiochem 5mg $187 2024-03-01 Buy
Tocris 6012 OXSI2 ≥98%(HPLC) 10 $185 2021-12-16 Buy
Tocris 6012 OXSI2 ≥98%(HPLC) 50 $774 2021-12-16 Buy
TRC O990038 OXSI2 1mg $105 2021-12-16 Buy

Properties

storage temp. :Store at -20°C
solubility :Soluble in DMSO
form :Orange powder solid.
color :Light yellow to brown
Sensitive :Light Sensitive

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Description

Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs (ITAMs) of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor is an oxindole compound that potently blocks Syk activity with an IC50 value of 5 nM and inhibits FcεRI-mediated rat RBL-2H3 basophil cell degranulation (EC50 = 1.4 μM). At 2 μM, this compound completely abolishes convulxin-induced platelet aggregation and shape change.

Suppliers and manufacturers

TargetMol Chemicals Inc.
OXSI-2
$138.00 /1mg
OXSI-2 CAS:622387-85-3
Career Henan Chemica Co VDM Biochemicals Shanghai EFE Biological Technology Co., Ltd. Shanghai Rechem science Co., Ltd. Shanghai Hongye Biotechnology Co. Ltd BOC Sciences ChemeGen(Shanghai) Biotechnology Co.,Ltd. MedBioPharmaceutical Technology Inc TargetMol Chemicals Inc.