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ChemicalBook >> CAS DataBase List >> BORRELIDIN

BORRELIDIN

BORRELIDIN price.
  • $81 - $1332
  • Product name: BORRELIDIN
  • CAS: 7184-60-3
  • MF: C28H43NO6
  • MW: 489.64
  • EINECS:
  • MDL Number:MFCD08276914
  • Synonyms:2-(7-CYANO-8,16-DIHYDROXY-9,11,13,15-TETRAMETHYL-18-OXOOXACYCLOOCTADECA-4,6-DIEN-2-YL)-CYCLOPENTANECARBOXYLIC ACID;BORRELIDIN;BORRELIDINE;2-(7-Cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxo-1-oxacyclooctadeca-4,6-dien-2-yl)cyclopentane-1-carboxylic acid;Aids128115;Aids-128115;Cyclopentanecarboxylic acid, 2-(7-cyano-8, 16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4, 6-dien-2-yl)-;Quinquangulin K 031
18 prices
Selected condition:
Brand
  • Adipogen Life Sciences
  • AK Scientific
  • ApexBio Technology
  • Biorbyt Ltd
  • Cayman Chemical
  • ChemScene
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 500μg
  • 1mg
  • 500ug
  • 1
  • 5mg
  • 10mg
  • ManufacturerAdipogen Life Sciences
  • Product numberBVT-0098-M005
  • Product descriptionBorrelidin ≥98%(HPLC)
  • Packaging5mg
  • Price$360
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number8443AJ
  • Product descriptionBorrelidin
  • Packaging5mg
  • Price$860
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number8443AJ
  • Product descriptionBorrelidin
  • Packaging10mg
  • Price$1332
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7699
  • Product descriptionBorrelidin
  • Packaging500ug
  • Price$410
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB7699
  • Product descriptionBorrelidin
  • Packaging1mg
  • Price$693
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb545895
  • Product descriptionborrelidin >98%
  • Packaging1mg
  • Price$372.3
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb545895
  • Product descriptionborrelidin >98%
  • Packaging5mg
  • Price$1315.8
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number14436
  • Product descriptionBorrelidin ≥98%
  • Packaging500μg
  • Price$81
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14436
  • Product descriptionBorrelidin ≥98%
  • Packaging1mg
  • Price$122
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0011785
  • Product descriptionBorrelidin >98.0%
  • Packaging500ug
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0011785
  • Product descriptionBorrelidin >98.0%
  • Packaging1mg
  • Price$340
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberB3061
  • Product descriptionBorrelidin from Streptomyces parvulus, ≥98% (HPLC)
  • Packaging1mg
  • Price$648
  • Updated2024-03-01
  • Buy
  • ManufacturerTocris
  • Product number4706
  • Product descriptionBorrelidin ≥98%(HPLC)
  • Packaging1
  • Price$316
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberB675390
  • Product descriptionBorrelidin
  • Packaging1mg
  • Price$370
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberB675390
  • Product descriptionBorrelidin
  • Packaging5mg
  • Price$1300
  • Updated2021-12-16
  • Buy
  • ManufacturerUsbiological
  • Product number207093
  • Product descriptionBorrelidin
  • Packaging500ug
  • Price$316
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences BVT-0098-M005 Borrelidin ≥98%(HPLC) 5mg $360 2021-12-16 Buy
AK Scientific 8443AJ Borrelidin 5mg $860 2021-12-16 Buy
AK Scientific 8443AJ Borrelidin 10mg $1332 2021-12-16 Buy
ApexBio Technology B7699 Borrelidin 500ug $410 2021-12-16 Buy
ApexBio Technology B7699 Borrelidin 1mg $693 2021-12-16 Buy
Biorbyt Ltd orb545895 borrelidin >98% 1mg $372.3 2021-12-16 Buy
Biorbyt Ltd orb545895 borrelidin >98% 5mg $1315.8 2021-12-16 Buy
Cayman Chemical 14436 Borrelidin ≥98% 500μg $81 2024-03-01 Buy
Cayman Chemical 14436 Borrelidin ≥98% 1mg $122 2024-03-01 Buy
ChemScene CS-0011785 Borrelidin >98.0% 500ug $200 2021-12-16 Buy
ChemScene CS-0011785 Borrelidin >98.0% 1mg $340 2021-12-16 Buy
Sigma-Aldrich B3061 Borrelidin from Streptomyces parvulus, ≥98% (HPLC) 1mg $648 2024-03-01 Buy
Tocris 4706 Borrelidin ≥98%(HPLC) 1 $316 2021-12-16 Buy
TRC B675390 Borrelidin 1mg $370 2021-12-16 Buy
TRC B675390 Borrelidin 5mg $1300 2021-12-16 Buy
Usbiological 207093 Borrelidin 500ug $316 2021-12-16 Buy

Properties

Melting point :143-145℃
Boiling point :584.45°C (rough estimate)
Density :1.1362 (rough estimate)
refractive index :1.6290 (estimate)
storage temp. :−20°C
solubility :DMSO: 1 mg/mL
form :White to off-white powder.
pka :4.56±0.40(Predicted)
color :Off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

Borrelidin is a secondary metabolite produced by Streptomyces and other bacteria. It displays potent antiangiogenic activity, preventing tube formation in rat aorta explants (IC50 = 0.8 nM) and inducing apoptosis in endothelial cells. Borrelidin also alters the splicing of VEGF mRNA, producing an antiangiogenic isoform of the growth factor. It has long been known as a powerful inhibitor of both eukaryotic and bacterial threonyl tRNA synthetase. Borrelidin is also an effective anti-malarial drug, as it kills P. falciparum with an IC50 value of 1.8 nM. At higher doses, it inhibits cyclin-dependent kinase in yeast (IC50 = 24 μM), resulting in growth arrest in the G1 phase.

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