COP-1
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- $97.2 - $505.37
- Product name: COP-1
- CAS: 28704-27-0
- MF: C23H41N5O11
- MW: 563.61
- EINECS:
- MDL Number:MFCD00166401
- Synonyms:[L-ALA, L-GLU, L-LYS HBR, L-TYR]N;COP-1;POLY(ALA, GLU, LYS, TYR) HYDROBROMIDE;(t,g)-a-l ;poly(ala;POLY(ALA, GLU, LYS, TYR) 6:2:5:1*HYDROBR OMIDE MOL.;Copaxone;(l-ala, l-glu, l-lys, l-tyr)n ·hbr
3 prices
Selected condition：
Brand
- American Custom Chemicals Corporation
- Sigma-Aldrich
Package
- 5MG
- 10mg
- 25mg
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0015275
- Product descriptionGLATIRAMER 95.00%
- Packaging5MG
- Price$505.37
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberP1152
- Product descriptionPoly(Ala, Glu, Lys, Tyr) 6:2:5:1 hydrobromide Ala:Glu:Lys:Tyr (6:2:5:1), mol wt 20,000-30,000
- Packaging25mg
- Price$490
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberP1152
- Product descriptionPoly(Ala, Glu, Lys, Tyr) 6:2:5:1 hydrobromide Ala:Glu:Lys:Tyr (6:2:5:1), mol wt 20,000-30,000
- Packaging10mg
- Price$97.2
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | API0015275 | GLATIRAMER 95.00% | 5MG | $505.37 | 2021-12-16 | Buy |
| Sigma-Aldrich | P1152 | Poly(Ala, Glu, Lys, Tyr) 6:2:5:1 hydrobromide Ala:Glu:Lys:Tyr (6:2:5:1), mol wt 20,000-30,000 | 25mg | $490 | 2024-03-01 | Buy |
| Sigma-Aldrich | P1152 | Poly(Ala, Glu, Lys, Tyr) 6:2:5:1 hydrobromide Ala:Glu:Lys:Tyr (6:2:5:1), mol wt 20,000-30,000 | 10mg | $97.2 | 2024-03-01 | Buy |
Properties
storage temp. :−20°C
Safety Information
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Description
Copaxone was launched in Israel and the US for treatment of relapsingremitting multiple sclerosis. The amino acid polymer is prepared from the Ncarboxyanhydrides of Tyr, Ala, γ-benzylglutamate and ε,N-trifluoroacetyllysine followed by deprotection. Structurally, the random polymer, with a residue molar ratio of 6.0:1.9:4.7:1.O=Ala:Glu:Lys:Tyr, simulates myelin basic protein (MBP). This gives it immunomodulating and immunosuppressive activity (antigen specific so not a general immunosuppressive). The mechanism involves binding to MHC class Ⅱ (I-A/DR) molecules which results both in competition with myelin antigens for T-cell activation and in induction of specific suppressor cells of the Th2 type. Therefore, the antigenspecific interaction gives rise to a reduced probability of long-term damage to the immune system. The competition with MBP and other myelin-associated antigens inhibits T-cell responses to MBP, and the binding occurs with high efficiency, fast rates and is non-species specific. It resulted in a 29% reduction in relapse rate and is most effective in patients with less accumulated neurologic disability.Related product price
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