COP-1
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2物価
選択条件:
ブランド
- Sigma-Aldrich Japan
パッケージ
- 10mg
- 25mg
- 生産者Sigma-Aldrich Japan
- 製品番号P1152
- 製品説明 Ala:Glu:Lys:Tyr (6:2:5:1), mol wt 20,000-30,000
- 英語製品説明Poly(Ala, Glu, Lys, Tyr) 6:2:5:1 hydrobromide Ala:Glu:Lys:Tyr (6:2:5:1), mol wt 20,000-30,000
- 包装単位10mg
- 価格¥25900
- 更新しました2024-03-01
- 購入
- 生産者Sigma-Aldrich Japan
- 製品番号P1152
- 製品説明 Ala:Glu:Lys:Tyr (6:2:5:1), mol wt 20,000-30,000
- 英語製品説明Poly(Ala, Glu, Lys, Tyr) 6:2:5:1 hydrobromide Ala:Glu:Lys:Tyr (6:2:5:1), mol wt 20,000-30,000
- 包装単位25mg
- 価格¥51000
- 更新しました2024-03-01
- 購入
生産者 | 製品番号 | 製品説明 | 包装単位 | 価格 | 更新時間 | 購入 |
---|---|---|---|---|---|---|
Sigma-Aldrich Japan | P1152 | Ala:Glu:Lys:Tyr (6:2:5:1), mol wt 20,000-30,000 Poly(Ala, Glu, Lys, Tyr) 6:2:5:1 hydrobromide Ala:Glu:Lys:Tyr (6:2:5:1), mol wt 20,000-30,000 |
10mg | ¥25900 | 2024-03-01 | 購入 |
Sigma-Aldrich Japan | P1152 | Ala:Glu:Lys:Tyr (6:2:5:1), mol wt 20,000-30,000 Poly(Ala, Glu, Lys, Tyr) 6:2:5:1 hydrobromide Ala:Glu:Lys:Tyr (6:2:5:1), mol wt 20,000-30,000 |
25mg | ¥51000 | 2024-03-01 | 購入 |
プロパティ
貯蔵温度 :−20°C
安全情報
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説明
Copaxone was launched in Israel and the US for treatment of relapsingremitting multiple sclerosis. The amino acid polymer is prepared from the Ncarboxyanhydrides of Tyr, Ala, γ-benzylglutamate and ε,N-trifluoroacetyllysine followed by deprotection. Structurally, the random polymer, with a residue molar ratio of 6.0:1.9:4.7:1.O=Ala:Glu:Lys:Tyr, simulates myelin basic protein (MBP). This gives it immunomodulating and immunosuppressive activity (antigen specific so not a general immunosuppressive). The mechanism involves binding to MHC class Ⅱ (I-A/DR) molecules which results both in competition with myelin antigens for T-cell activation and in induction of specific suppressor cells of the Th2 type. Therefore, the antigenspecific interaction gives rise to a reduced probability of long-term damage to the immune system. The competition with MBP and other myelin-associated antigens inhibits T-cell responses to MBP, and the binding occurs with high efficiency, fast rates and is non-species specific. It resulted in a 29% reduction in relapse rate and is most effective in patients with less accumulated neurologic disability.関連商品価格
- トリス(2,4-ペンタンジオナト)鉄(III)
¥3000-86600 - ブチルイソシアニド
¥10200-204600 - ジクロロ(エチレンジアミン)白金(II)
¥25700-96800