COP-1

COP-1 価格 もっと(2)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
Sigma-Aldrich Japan	P1152	Ala:Glu:Lys:Tyr (6:2:5:1), mol wt 20,000-30,000 Poly(Ala, Glu, Lys, Tyr) 6:2:5:1 hydrobromide Ala:Glu:Lys:Tyr (6:2:5:1), mol wt 20,000-30,000	28704-27-0	10mg	￥25900	2024-03-01	購入
Sigma-Aldrich Japan	P1152	Ala:Glu:Lys:Tyr (6:2:5:1), mol wt 20,000-30,000 Poly(Ala, Glu, Lys, Tyr) 6:2:5:1 hydrobromide Ala:Glu:Lys:Tyr (6:2:5:1), mol wt 20,000-30,000	28704-27-0	25mg	￥51000	2024-03-01	購入

COP-1 化学特性,用途語,生産方法

説明

Copaxone was launched in Israel and the US for treatment of relapsingremitting multiple sclerosis. The amino acid polymer is prepared from the Ncarboxyanhydrides of Tyr, Ala, γ-benzylglutamate and ε,N-trifluoroacetyllysine followed by deprotection. Structurally, the random polymer, with a residue molar ratio of 6.0:1.9:4.7:1.O=Ala:Glu:Lys:Tyr, simulates myelin basic protein (MBP). This gives it immunomodulating and immunosuppressive activity (antigen specific so not a general immunosuppressive). The mechanism involves binding to MHC class Ⅱ (I-A/DR) molecules which results both in competition with myelin antigens for T-cell activation and in induction of specific suppressor cells of the Th2 type. Therefore, the antigenspecific interaction gives rise to a reduced probability of long-term damage to the immune system. The competition with MBP and other myelin-associated antigens inhibits T-cell responses to MBP, and the binding occurs with high efficiency, fast rates and is non-species specific. It resulted in a 29% reduction in relapse rate and is most effective in patients with less accumulated neurologic disability.

Originator

Yeda (Israel)

brand name

Copaxone

COP-1 上流と下流の製品情報

原材料

準備製品

COP-1 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
Protheragen-ING	+16313385890	info@protheragen-ing.com	United States	1091	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
DONBOO AMINO ACID COMPANY	+8613063595538	donboo@donboo.com	China	9365	58
Nanjing Peptide Biotech Ltd.	025-025-58361106-805-805 13082558573	liugang@njpeptide.com	China	9978	55
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44941	58
Guangzhou Yunmen Biotechnology Co., Ltd	18902340307 18902340307	3356812514@qq.com	China	9249	58
Nanjing Yuanpeptide Biotech Co.，Ltd.	18168071971	support@yuan-peptide.com	China	2977	58
HUBEI HICKS BIOCHEMICAL CO.,LTD	18696113233	15927219311@163.com	China	1616	58
Hubei Hicks Biochemical Co., Ltd	17362916295; 17362916295	w17362916295@163.com	China	4054	58
Zhejiang Jiekun Biotechnology Co., Ltd	0571-88211951 13735575465	sales1@gotopbio.com	China	4904	58

28704-27-0()キーワード:

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• 28704-27-0
• [L-ALA, L-GLU, L-LYS HBR, L-TYR]N
• COP-1
• POLY(ALA, GLU, LYS, TYR) HYDROBROMIDE
• (t,g)-a-l
• poly(ala
• POLY(ALA, GLU, LYS, TYR) 6:2:5:1*HYDROBR OMIDE MOL.
• Copaxone
• (l-ala, l-glu, l-lys, l-tyr)n ·hbr
• poly(ala, glu, lys, tyr) 6:2:5:1 hydrobromide
• poly(alanine-glutamic acid-lysine-tyrosine)
• COP-1, (L-Ala, L-Glu, L-Lys, L-Tyr)n HBr
• Poly(Ala, Glu, Lys, Tyr) 6:2:5:1 hydrobromide Ala:Glu:Lys:Tyr (6:2:5:1), mol wt 20,000-30,000