COP-1
- CAS No.
- 28704-27-0
- Chemical Name:
- COP-1
- Synonyms
- COP-1;Copaxone;poly(ala;(t,g)-a-l;[L-ALA, L-GLU, L-LYS HBR, L-TYR]N;(l-ala, l-glu, l-lys, l-tyr)n ·hbr;POLY(ALA, GLU, LYS, TYR) HYDROBROMIDE;poly(alanine-glutamic acid-lysine-tyrosine);COP-1, (L-Ala, L-Glu, L-Lys, L-Tyr)n HBr;poly(ala, glu, lys, tyr) 6:2:5:1 hydrobromide
- CBNumber:
- CB2151979
- Molecular Formula:
- C23H41N5O11
- Molecular Weight:
- 563.61
- MDL Number:
- MFCD00166401
- MOL File:
- 28704-27-0.mol
| storage temp. | −20°C |
|---|---|
| FDA UNII | U782C039QP |
COP-1 price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P1152 | Poly(Ala, Glu, Lys, Tyr) 6:2:5:1 hydrobromide Ala:Glu:Lys:Tyr (6:2:5:1), mol wt 20,000-30,000 | 28704-27-0 | 10mg | $97.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | P1152 | Poly(Ala, Glu, Lys, Tyr) 6:2:5:1 hydrobromide Ala:Glu:Lys:Tyr (6:2:5:1), mol wt 20,000-30,000 | 28704-27-0 | 25mg | $490 | 2024-03-01 | Buy |
| American Custom Chemicals Corporation | API0015275 | GLATIRAMER 95.00% | 28704-27-0 | 5MG | $505.37 | 2021-12-16 | Buy |
COP-1 Chemical Properties,Uses,Production
Description
Copaxone was launched in Israel and the US for treatment of relapsingremitting multiple sclerosis. The amino acid polymer is prepared from the Ncarboxyanhydrides of Tyr, Ala, γ-benzylglutamate and ε,N-trifluoroacetyllysine followed by deprotection. Structurally, the random polymer, with a residue molar ratio of 6.0:1.9:4.7:1.O=Ala:Glu:Lys:Tyr, simulates myelin basic protein (MBP). This gives it immunomodulating and immunosuppressive activity (antigen specific so not a general immunosuppressive). The mechanism involves binding to MHC class Ⅱ (I-A/DR) molecules which results both in competition with myelin antigens for T-cell activation and in induction of specific suppressor cells of the Th2 type. Therefore, the antigenspecific interaction gives rise to a reduced probability of long-term damage to the immune system. The competition with MBP and other myelin-associated antigens inhibits T-cell responses to MBP, and the binding occurs with high efficiency, fast rates and is non-species specific. It resulted in a 29% reduction in relapse rate and is most effective in patients with less accumulated neurologic disability.
Originator
Yeda (Israel)
brand name
Copaxone
COP-1 Preparation Products And Raw materials
Raw materials
Preparation Products
COP-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Protheragen-ING | +16313385890 | info@protheragen-ing.com | United States | 1091 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| DONBOO AMINO ACID COMPANY | +8613063595538 | donboo@donboo.com | China | 9365 | 58 |
| Nanjing Peptide Biotech Ltd. | 025-025-58361106-805-805 13082558573 | liugang@njpeptide.com | China | 9962 | 55 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Guangzhou Yunmen Biotechnology Co., Ltd | 18902340307 18902340307 | 3356812514@qq.com | China | 9241 | 58 |
| Nanjing Yuanpeptide Biotech Co.，Ltd. | 18168071971 | support@yuan-peptide.com | China | 2977 | 58 |
| HUBEI HICKS BIOCHEMICAL CO.,LTD | 18696113233 | 15927219311@163.com | China | 1624 | 58 |
| Hubei Hicks Biochemical Co., Ltd | 17362916295; 17362916295 | w17362916295@163.com | China | 4055 | 58 |
| Zhejiang Jiekun Biotechnology Co., Ltd | 0571-88211951 13735575465 | sales1@gotopbio.com | China | 4904 | 58 |
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