COP-1

COP-1 C화학적 특성, 용도, 생산

개요

Copaxone was launched in Israel and the US for treatment of relapsingremitting multiple sclerosis. The amino acid polymer is prepared from the Ncarboxyanhydrides of Tyr, Ala, γ-benzylglutamate and ε,N-trifluoroacetyllysine followed by deprotection. Structurally, the random polymer, with a residue molar ratio of 6.0:1.9:4.7:1.O=Ala:Glu:Lys:Tyr, simulates myelin basic protein (MBP). This gives it immunomodulating and immunosuppressive activity (antigen specific so not a general immunosuppressive). The mechanism involves binding to MHC class Ⅱ (I-A/DR) molecules which results both in competition with myelin antigens for T-cell activation and in induction of specific suppressor cells of the Th2 type. Therefore, the antigenspecific interaction gives rise to a reduced probability of long-term damage to the immune system. The competition with MBP and other myelin-associated antigens inhibits T-cell responses to MBP, and the binding occurs with high efficiency, fast rates and is non-species specific. It resulted in a 29% reduction in relapse rate and is most effective in patients with less accumulated neurologic disability.

Originator

Yeda (Israel)

상표명

Copaxone

COP-1 준비 용품 및 원자재

원자재

준비 용품

COP-1 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Protheragen-ING	+16313385890	info@protheragen-ing.com	United States	1091	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
DONBOO AMINO ACID COMPANY	+8613063595538	donboo@donboo.com	China	9365	58
Nanjing Peptide Biotech Ltd.	025-025-58361106-805-805 13082558573	liugang@njpeptide.com	China	9962	55
Chengdu Youngshe Chemical Co., Ltd.	+86-17380623303 +86-17380623303	Caroline@youngshechem.com	China	5392	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44941	58
Guangzhou Yunmen Biotechnology Co., Ltd	18902340307 18902340307	3356812514@qq.com	China	9243	58
Nanjing Yuanpeptide Biotech Co.，Ltd.	18168071971	support@yuan-peptide.com	China	2977	58
HUBEI HICKS BIOCHEMICAL CO.,LTD	18696113233	15927219311@163.com	China	1616	58
Hubei Hicks Biochemical Co., Ltd	17362916295; 17362916295	w17362916295@163.com	China	4054	58

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