GNF5
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- $37 - $2245.7
- Product name: GNF5
- CAS: 778277-15-9
- MF: C20H17F3N4O3
- MW: 418.37
- EINECS:200-256-5
- MDL Number:MFCD16877246
- Synonyms:GNF 5;GNF5;GNF-5;N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide;ert-butyl 2-oxopiperidine-1-carboxylate;GNF 5 N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide;N-(2-Hydroxyethyl)-3-[6-[[4-(trifluoromethoxy)phenyl]amino]-4-pyrimidinyl]benzamide GNF-5;GNF-5, >=98%
24 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- ApexBio Technology
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 10
- 5mg
- 10mg
- 50mg
- 50
- 25mg
- 100mg
- 250mg
- 1g
- 1000mg
- ManufacturerAK Scientific
- Product number2436AH
- Product descriptionN-(2-Hydroxyethyl)-3-[6-[4-(trifluoromethoxy)anilino]pyrimidin-4-yl]benzamide
- Packaging5mg
- Price$82
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2436AH
- Product descriptionN-(2-Hydroxyethyl)-3-[6-[4-(trifluoromethoxy)anilino]pyrimidin-4-yl]benzamide
- Packaging1g
- Price$1072
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA117001
- Product descriptionN-(2-Hydroxyethyl)-3-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)benzamide 98+%
- Packaging10mg
- Price$38
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA117001
- Product descriptionN-(2-Hydroxyethyl)-3-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)benzamide 98+%
- Packaging50mg
- Price$96
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA117001
- Product descriptionN-(2-Hydroxyethyl)-3-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)benzamide 98+%
- Packaging100mg
- Price$144
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8604
- Product descriptionGNF5
- Packaging10mg
- Price$45
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181250
- Product descriptionGNF-5 >98%
- Packaging100mg
- Price$542.3
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181250
- Product descriptionGNF-5 >98%
- Packaging250mg
- Price$912.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181250
- Product descriptionGNF-5 >98%
- Packaging1000mg
- Price$2245.7
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16254
- Product descriptionGNF-5 ≥95%
- Packaging5mg
- Price$37
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16254
- Product descriptionGNF-5 ≥95%
- Packaging10mg
- Price$65
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16254
- Product descriptionGNF-5 ≥95%
- Packaging25mg
- Price$108
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16254
- Product descriptionGNF-5 ≥95%
- Packaging50mg
- Price$195
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-1811
- Product descriptionGNF-5 99.78%
- Packaging10mg
- Price$60
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1811
- Product descriptionGNF-5 99.78%
- Packaging50mg
- Price$180
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1811
- Product descriptionGNF-5 99.78%
- Packaging100mg
- Price$288
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2436AH | N-(2-Hydroxyethyl)-3-[6-[4-(trifluoromethoxy)anilino]pyrimidin-4-yl]benzamide | 5mg | $82 | 2021-12-16 | Buy |
| AK Scientific | 2436AH | N-(2-Hydroxyethyl)-3-[6-[4-(trifluoromethoxy)anilino]pyrimidin-4-yl]benzamide | 1g | $1072 | 2021-12-16 | Buy |
| Ambeed | A117001 | N-(2-Hydroxyethyl)-3-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)benzamide 98+% | 10mg | $38 | 2021-12-16 | Buy |
| Ambeed | A117001 | N-(2-Hydroxyethyl)-3-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)benzamide 98+% | 50mg | $96 | 2021-12-16 | Buy |
| Ambeed | A117001 | N-(2-Hydroxyethyl)-3-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)benzamide 98+% | 100mg | $144 | 2021-12-16 | Buy |
| ApexBio Technology | A8604 | GNF5 | 10mg | $45 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181250 | GNF-5 >98% | 100mg | $542.3 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181250 | GNF-5 >98% | 250mg | $912.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181250 | GNF-5 >98% | 1000mg | $2245.7 | 2021-12-16 | Buy |
| Cayman Chemical | 16254 | GNF-5 ≥95% | 5mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 16254 | GNF-5 ≥95% | 10mg | $65 | 2024-03-01 | Buy |
| Cayman Chemical | 16254 | GNF-5 ≥95% | 25mg | $108 | 2024-03-01 | Buy |
| Cayman Chemical | 16254 | GNF-5 ≥95% | 50mg | $195 | 2024-03-01 | Buy |
| ChemScene | CS-1811 | GNF-5 99.78% | 10mg | $60 | 2021-12-16 | Buy |
| ChemScene | CS-1811 | GNF-5 99.78% | 50mg | $180 | 2021-12-16 | Buy |
| ChemScene | CS-1811 | GNF-5 99.78% | 100mg | $288 | 2021-12-16 | Buy |
Properties
Boiling point :612.4±55.0 °C(Predicted)
Density :1.385±0.06 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,2-8°C
solubility :DMSO: soluble10mg/mL (clear solution)
pka :13.36±0.46(Predicted)
form :powder
color :white to beige
Density :1.385±0.06 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,2-8°C
solubility :DMSO: soluble10mg/mL (clear solution)
pka :13.36±0.46(Predicted)
form :powder
color :white to beige
Safety Information
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| Signal word: | Danger | |||||||||||||||||||||
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Description
Bcr-Abl, a fusion protein with deregulated tyrosine kinase activity, is highly expressed in chronic myelogenous leukemia. GNF-5 is the N-hydroxyethyl carboamide analog of GNF-2 , a selective allosteric inhibitor of Bcr-Abl. GNF-5 demonstrates IC50 values of 4.52, 0.38, and 0.93 μM against Bcr-Abl mutants G250E, E255V, and M351T, respectively. When used in combination with the ATP-competitive Bcr-Abl inhibitors imatinib or nilotinib , GNF-5 displays additive inhibitory activity against T315I Bcr-Abl mutants both in in vitro assays and in a recalcitrant T315I Bcr-Abl mutant mouse bone marrow transplantation model.Related product price
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