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ChemicalBook >> CAS DataBase List >> HA-1004 (hydrochloride)

HA-1004 (hydrochloride)

HA-1004 (hydrochloride) price.
2 prices
Selected condition:
Brand
  • Cayman Chemical
Package
  • 5mg
  • 10mg
  • ManufacturerCayman Chemical
  • Product number10010558
  • Product descriptionHA-1004 (hydrochloride)
  • Packaging5mg
  • Price$54
  • Updated2022-04-27
  • Buy
  • ManufacturerCayman Chemical
  • Product number10010558
  • Product descriptionHA-1004 (hydrochloride)
  • Packaging10mg
  • Price$96
  • Updated2022-04-27
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Cayman Chemical 10010558 HA-1004 (hydrochloride) 5mg $54 2022-04-27 Buy
Cayman Chemical 10010558 HA-1004 (hydrochloride) 10mg $96 2022-04-27 Buy

Properties

storage temp. :Store at -20°C
solubility :DMF:2.0(Max Conc. mg/mL);5.46(Max Conc. mM)
DMSO:3.0(Max Conc. mg/mL);8.19(Max Conc. mM)
PBS (pH 7.2):5.0(Max Conc. mg/mL);13.65(Max Conc. mM)

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

HA-1004 is an inhibitor of protein kinase G (PKG) and PKA (Kis = 1.4 and 2.3 μM, respectively). It also inhibits PKC and blocks intracellular calcium mobilization. HA-1004 induces relaxation of isolated rabbit aortic strips precontracted with histamine, serotonin , A23187 , angiotensin II , or prostaglandin F (; EC50s = 0.32-0.63 μM), as well as phenylephrine (Item Nos. 18619 | 17205) with or without calcium (EC50s = 2.3 and 0.5 μM, respectively). It also inhibits histamine-induced bronchoconstriction in guinea pigs without affecting blood pressure when administered intratracheally at a dose of 0.1 mg per animal.