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ChemicalBook >> HPI-1 Hydrate

HPI-1 Hydrate

HPI-1 Hydrate price.
  • $106 - $775
  • Product name: HPI-1 Hydrate
  • CAS: 1262770-72-8
  • MF: C27H31NO7
  • MW: 481.53754
  • EINECS:
  • MDL Number:
  • Synonyms:HPI-1 Hydrate;1,4,5,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7-(2-Methoxyphenyl)-2-Methyl-5-oxo-3-quinolinecarboxylic Acid 2-Methoxyethyl Ester Hydrate
5 prices
Selected condition:
Brand
  • Cayman Chemical
  • TRC
Package
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • ManufacturerCayman Chemical
  • Product number15221
  • Product descriptionHPI-1 (hydrate)
  • Packaging5mg
  • Price$106
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15221
  • Product descriptionHPI-1 (hydrate)
  • Packaging10mg
  • Price$187
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15221
  • Product descriptionHPI-1 (hydrate)
  • Packaging25mg
  • Price$440
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15221
  • Product descriptionHPI-1 (hydrate)
  • Packaging50mg
  • Price$775
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberH671250
  • Product descriptionHPI-1 hydrate
  • Packaging25mg
  • Price$130
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Cayman Chemical 15221 HPI-1 (hydrate) 5mg $106 2024-03-01 Buy
Cayman Chemical 15221 HPI-1 (hydrate) 10mg $187 2024-03-01 Buy
Cayman Chemical 15221 HPI-1 (hydrate) 25mg $440 2024-03-01 Buy
Cayman Chemical 15221 HPI-1 (hydrate) 50mg $775 2024-03-01 Buy
TRC H671250 HPI-1 hydrate 25mg $130 2021-12-16 Buy

Properties


Safety Information

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Description

HPI-1 (hydrate) is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Sonic Hh (IC50 = 1.5 μM) without significantly affecting Wnt signaling (IC50 ≥ 30 μM). HPI-1 suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression, suggesting action at posttranslational modification of Gli protein or at the interaction of Gli with a co-factor. HPI-1 (hydrate) also inhibits signaling through the oncogenic Smoothened (Smo) mutant SmoM2 in neuron precursors, preventing cell proliferation.