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ChemicalBook >> CAS DataBase List >> PD 153035 HYDROCHLORIDE

PD 153035 HYDROCHLORIDE

PD 153035 HYDROCHLORIDE price.
  • $28 - $1476
  • Product name: PD 153035 HYDROCHLORIDE
  • CAS: 153436-54-5
  • MF: C16H14BrN3O2
  • MW: 360.21
  • EINECS:
  • MDL Number:MFCD00934896
  • Synonyms:PD 153035 HYDROCHLORIDE;PD153035HCl;4-(3-Bromphenylamino)-6,7-bis(methoxy)quinazoline;4-(3-Bromphenylamino)-6,7-dimethylquinazoline;4-Quinazolinamine, N-(3-bromphenyl)-6,7-dimethoxy-;Zinc00600292;4-(3-Bromo-benzyl)-6,7-dimethoxy-quinazoline;N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine
34 prices
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  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Labseeker
  • Matrix Scientific
  • Tocris
  • TRC
Package
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  • 25mg
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  • 250mg
  • 1g
  • 50
  • 10g
  • 10mM(in 1mL DMSO)
  • 5g
  • ManufacturerAK Scientific
  • Product numberW3343
  • Product descriptionN-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine
  • Packaging5g
  • Price$1476
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA100205
  • Product descriptionN-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine 99+%
  • Packaging5mg
  • Price$84
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA100205
  • Product descriptionN-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine 99+%
  • Packaging10mg
  • Price$108
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA100205
  • Product descriptionN-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine 99+%
  • Packaging50mg
  • Price$181
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA100205
  • Product descriptionN-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine 99+%
  • Packaging100mg
  • Price$235
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA100205
  • Product descriptionN-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine 99+%
  • Packaging250mg
  • Price$352
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA100205
  • Product descriptionN-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine 99+%
  • Packaging1g
  • Price$879
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000860
  • Product descriptionN-(3-BROMOPHENYL)-6,7-DIMETHOXYQUINAZOLIN-4-AMINE 95.00%
  • Packaging10MG
  • Price$673.08
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000860
  • Product descriptionN-(3-BROMOPHENYL)-6,7-DIMETHOXYQUINAZOLIN-4-AMINE 95.00%
  • Packaging50MG
  • Price$1102.4
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8199
  • Product descriptionPD153035 hydrochloride
  • Packaging1unit
  • Price$28
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8199
  • Product descriptionPD153035 hydrochloride
  • Packaging10mM(in 1mL DMSO)
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS424835
  • Product descriptionN-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine ≥99%
  • Packaging5mg
  • Price$30
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS424835
  • Product descriptionN-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine ≥99%
  • Packaging10mg
  • Price$40
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS424835
  • Product descriptionN-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine ≥99%
  • Packaging50mg
  • Price$67
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS424835
  • Product descriptionN-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine ≥99%
  • Packaging100mg
  • Price$96
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS424835
  • Product descriptionN-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine ≥99%
  • Packaging250mg
  • Price$146
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific W3343 N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine 5g $1476 2021-12-16 Buy
Ambeed A100205 N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine 99+% 5mg $84 2021-12-16 Buy
Ambeed A100205 N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine 99+% 10mg $108 2021-12-16 Buy
Ambeed A100205 N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine 99+% 50mg $181 2021-12-16 Buy
Ambeed A100205 N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine 99+% 100mg $235 2021-12-16 Buy
Ambeed A100205 N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine 99+% 250mg $352 2021-12-16 Buy
Ambeed A100205 N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine 99+% 1g $879 2021-12-16 Buy
American Custom Chemicals Corporation INB0000860 N-(3-BROMOPHENYL)-6,7-DIMETHOXYQUINAZOLIN-4-AMINE 95.00% 10MG $673.08 2021-12-16 Buy
American Custom Chemicals Corporation INB0000860 N-(3-BROMOPHENYL)-6,7-DIMETHOXYQUINAZOLIN-4-AMINE 95.00% 50MG $1102.4 2021-12-16 Buy
ApexBio Technology A8199 PD153035 hydrochloride 1unit $28 2021-12-16 Buy
ApexBio Technology A8199 PD153035 hydrochloride 10mM(in 1mL DMSO) $65 2021-12-16 Buy
Arctom AS424835 N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine ≥99% 5mg $30 2021-12-16 Buy
Arctom AS424835 N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine ≥99% 10mg $40 2021-12-16 Buy
Arctom AS424835 N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine ≥99% 50mg $67 2021-12-16 Buy
Arctom AS424835 N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine ≥99% 100mg $96 2021-12-16 Buy
Arctom AS424835 N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine ≥99% 250mg $146 2021-12-16 Buy

Properties

Melting point :189-190 °C
Boiling point :472.1±45.0 °C(Predicted)
Density :1.499±0.06 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,2-8°C
solubility :Soluble in DMSO (up to 5 mg/ml).
pka :5.55±0.30(Predicted)
form :White to off-white solid.
color :White or off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

PD 153035 is a potent, reversible inhibitor of EGFR kinase (Ki = 5.2 pM; IC50 = 29 pM). It less effectively inhibits HER2 (IC50 = 2.3 μM) and has little effect on several other receptor and non-receptor tyrosine kinases. PD 153035 has been shown to rapidly suppress autophosphorylation of EGFR in ?broblasts and human epidermoid carcinoma cells, as well as to selectively block EGF-mediated cellular processes, including mitogenesis and early gene expression.

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