Welcome to chemicalbook!
400-158-6606
Inquriy
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook >> CAS DataBase List >> S3I-201

S3I-201

S3I-201 price.
  • $55 - $5346
  • Product name: S3I-201
  • CAS: 501919-59-1
  • MF: C16H15NO7S
  • MW: 365.36
  • EINECS:
  • MDL Number:MFCD09907564
  • Synonyms:S2I-201;2-Hydroxy-4-[[2-[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]benzoic acid NSC 74859(S3I-201);2-Hydroxy-4-[[[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoic acid;Stat3 Inhibitor I, S3I-201;OTAVA-BB 7070707021;S31-201 (NSC 74859);NSC 74859, >=98%;OTAVA-BB 7070707021S31-201 (NSC 74859),S3I-201
32 prices
Selected condition:
Brand
  • AK Scientific
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biorbyt Ltd
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 10
  • 100mg
  • 250mg
  • 1g
  • 50
  • 5g
  • 10g
  • ManufacturerAK Scientific
  • Product numberX7562
  • Product description2-Hydroxy-4-[[[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoicacid
  • Packaging5g
  • Price$4861
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8338
  • Product descriptionNSC74859
  • Packaging10mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60350
  • Product descriptionS3I-201 ≥98%
  • Packaging10mg
  • Price$168
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2313
  • Product descriptionS3I201-NSC74859 99%
  • Packaging10mg
  • Price$99
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2313
  • Product descriptionS3I201-NSC74859 99%
  • Packaging50mg
  • Price$297
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb154617
  • Product descriptionS3I-201 (NSC-74859) >98%
  • Packaging100mg
  • Price$606.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb154617
  • Product descriptionS3I-201 (NSC-74859) >98%
  • Packaging250mg
  • Price$912.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb154617
  • Product descriptionS3I-201 (NSC-74859) >98%
  • Packaging1g
  • Price$1802
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number14336
  • Product descriptionS3I-201 ≥95%
  • Packaging5mg
  • Price$63
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14336
  • Product descriptionS3I-201 ≥95%
  • Packaging10mg
  • Price$117
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14336
  • Product descriptionS3I-201 ≥95%
  • Packaging25mg
  • Price$243
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14336
  • Product descriptionS3I-201 ≥95%
  • Packaging50mg
  • Price$335
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0512
  • Product descriptionNSC74859 99.50%
  • Packaging5mg
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0512
  • Product descriptionNSC74859 99.50%
  • Packaging10mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0512
  • Product descriptionNSC74859 99.50%
  • Packaging50mg
  • Price$175
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0512
  • Product descriptionNSC74859 99.50%
  • Packaging100mg
  • Price$330
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific X7562 2-Hydroxy-4-[[[[(4-methylphenyl)sulfonyl]oxy]acetyl]amino]-benzoicacid 5g $4861 2021-12-16 Buy
ApexBio Technology A8338 NSC74859 10mg $70 2021-12-16 Buy
Arctom CFN60350 S3I-201 ≥98% 10mg $168 2021-12-16 Buy
Axon Medchem Axon2313 S3I201-NSC74859 99% 10mg $99 2021-12-16 Buy
Axon Medchem Axon2313 S3I201-NSC74859 99% 50mg $297 2021-12-16 Buy
Biorbyt Ltd orb154617 S3I-201 (NSC-74859) >98% 100mg $606.9 2021-12-16 Buy
Biorbyt Ltd orb154617 S3I-201 (NSC-74859) >98% 250mg $912.9 2021-12-16 Buy
Biorbyt Ltd orb154617 S3I-201 (NSC-74859) >98% 1g $1802 2021-12-16 Buy
Cayman Chemical 14336 S3I-201 ≥95% 5mg $63 2024-03-01 Buy
Cayman Chemical 14336 S3I-201 ≥95% 10mg $117 2024-03-01 Buy
Cayman Chemical 14336 S3I-201 ≥95% 25mg $243 2024-03-01 Buy
Cayman Chemical 14336 S3I-201 ≥95% 50mg $335 2024-03-01 Buy
ChemScene CS-0512 NSC74859 99.50% 5mg $55 2021-12-16 Buy
ChemScene CS-0512 NSC74859 99.50% 10mg $70 2021-12-16 Buy
ChemScene CS-0512 NSC74859 99.50% 50mg $175 2021-12-16 Buy
ChemScene CS-0512 NSC74859 99.50% 100mg $330 2021-12-16 Buy

Properties

Melting point :>185oC (dec.)
Boiling point :654.7±55.0 °C(Predicted)
Density :1.507
storage temp. :-20°C
solubility :DMSO: >10mg/mL
pka :2.98±0.10(Predicted)
form :powder
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P501 Dispose of contents/container to..…

Description

Signal transducers and activators of transcription (STATs) are a family of latent cytoplasmic transcription factors that convey signals from the cell membrane to the nucleus. In various human tumors, STAT3 is constitutively activated by aberrant upstream tyrosine kinase activities. STAT signaling is also suspected to play a role in vascular disease since it can be activated through angiotensin II type 1 receptors or the inflammatory mediator interleukin (IL)-6. S3I-201 is an inhibitor of STAT3 transcription factor activation, dimerization, and gene transcription. It can suppress IL-6-induced phosphorylation of STAT3 in T cells with an IC50 value of 38 μM. Inhibiting STAT3 activation with 10 μM S3I-201 was demonstrated to be protective against angiotensin II-induced oxidative stress, endothelial dysfunction, and hypertension in two different models of vascular disease. At 10 μM, S3I-201 has also been used as a means to regress cardiac hypertrophy by inhibiting collagen biosynthesis and decreasing atrial natriuretic factor and β-myosin heavy chain in an in vitro model.

Related product price