SB 223412
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- $81 - $2691.1
- Product name: SB 223412
- CAS: 174636-32-9
- MF: C25H22N2O2
- MW: 382.45
- EINECS:
- MDL Number:MFCD00944075
- Synonyms:SB 223412;3-hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide;(-)-(S)-N-(alpha-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carboxaMide;TALNETANT//SB223412//3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxaMide;(-)-3-Hydroxy-2-phenyl-N-[1(S)-phenylpropyl]quinoline-4-carboxamide;(S)-N-(1-Phenylpropyl)-3-hydroxy-2-phenylquinoline-4-carboxamide;3-hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide;3-Hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide
26 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- ApexBio Technology
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
Package
- 50
- 5mg
- 10
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 500mg
- 1000mg
- 1g
- 10g
- ManufacturerAK Scientific
- Product number2640BB
- Product descriptionTalnetant
- Packaging500mg
- Price$451
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA303351
- Product descriptionTalnetant 98+%
- Packaging5mg
- Price$111
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA303351
- Product descriptionTalnetant 98+%
- Packaging50mg
- Price$509
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3854
- Product descriptionTalnetant
- Packaging10mg
- Price$197
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180970
- Product descriptionTalnetant (SB 223412) >98%
- Packaging100mg
- Price$690.2
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180970
- Product descriptionTalnetant (SB 223412) >98%
- Packaging250mg
- Price$1356.6
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180970
- Product descriptionTalnetant (SB 223412) >98%
- Packaging1000mg
- Price$2691.1
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number29699
- Product descriptionTalnetant
- Packaging100mg
- Price$81
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number29699
- Product descriptionTalnetant
- Packaging250mg
- Price$169
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number29699
- Product descriptionTalnetant
- Packaging500mg
- Price$317
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM146002
- Product description(S)-3-hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide 98%
- Packaging50mg
- Price$343
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1638
- Product descriptionTalnetant 99.43%
- Packaging10mg
- Price$162
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1638
- Product descriptionTalnetant 99.43%
- Packaging50mg
- Price$677
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31002971
- Product descriptionTalnetant 98+%
- Packaging10mg
- Price$88
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31002971
- Product descriptionTalnetant 98+%
- Packaging50mg
- Price$367
- Updated2021-12-16
- Buy
- ManufacturerCSNpharm
- Product numberCSN13678
- Product descriptionTalnetant
- Packaging5mg
- Price$81
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2640BB | Talnetant | 500mg | $451 | 2021-12-16 | Buy |
| Ambeed | A303351 | Talnetant 98+% | 5mg | $111 | 2021-12-16 | Buy |
| Ambeed | A303351 | Talnetant 98+% | 50mg | $509 | 2021-12-16 | Buy |
| ApexBio Technology | A3854 | Talnetant | 10mg | $197 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180970 | Talnetant (SB 223412) >98% | 100mg | $690.2 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180970 | Talnetant (SB 223412) >98% | 250mg | $1356.6 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180970 | Talnetant (SB 223412) >98% | 1000mg | $2691.1 | 2021-12-16 | Buy |
| Cayman Chemical | 29699 | Talnetant | 100mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 29699 | Talnetant | 250mg | $169 | 2024-03-01 | Buy |
| Cayman Chemical | 29699 | Talnetant | 500mg | $317 | 2024-03-01 | Buy |
| Chemenu | CM146002 | (S)-3-hydroxy-2-phenyl-N-(1-phenylpropyl)quinoline-4-carboxamide 98% | 50mg | $343 | 2021-12-16 | Buy |
| ChemScene | CS-1638 | Talnetant 99.43% | 10mg | $162 | 2021-12-16 | Buy |
| ChemScene | CS-1638 | Talnetant 99.43% | 50mg | $677 | 2021-12-16 | Buy |
| Crysdot | CD31002971 | Talnetant 98+% | 10mg | $88 | 2021-12-16 | Buy |
| Crysdot | CD31002971 | Talnetant 98+% | 50mg | $367 | 2021-12-16 | Buy |
| CSNpharm | CSN13678 | Talnetant | 5mg | $81 | 2021-12-16 | Buy |
Properties
Melting point :125.1-126.2℃
Boiling point :580.4±50.0 °C(Predicted)
Density :1.212±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: soluble25mg/mL, clear
form :powder
pka :6.70±0.50(Predicted)
color :white to beige
optical activity :[α]/D -25 to -31°, c = 0.5 in methanol
Boiling point :580.4±50.0 °C(Predicted)
Density :1.212±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :DMSO: soluble25mg/mL, clear
form :powder
pka :6.70±0.50(Predicted)
color :white to beige
optical activity :[α]/D -25 to -31°, c = 0.5 in methanol
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
Talnetant is an antagonist of the neurokinin-3 (NK3) receptor (Ki = 1 nM). It is selective for NK3 over NK1 and NK2 receptors (Kis = 144 and >100,000 nM, respectively, in CHO cells expressing recombinant human receptors). Talnetant inhibits calcium mobilization induced by neurokinin B in HEK293 cells expressing human NK3 receptors (IC50 = 16.6 nM). It inhibits contractions induced by the NK3 receptor agonist senktide in isolated rabbit iris sphincter muscle (pD2 = 9.1). Talnetant (5-20 mg/kg) reduces senktide-induced head shakes and tail whips in mice. It also inhibits senktide-induced wet-dog shakes, increases extracellular dopamine and norepinephrine in the medial prefrontal cortex, and attenuates haloperidol-induced increases in nucleus accumbens dopamine levels in guinea pigs.Suppliers and manufacturers
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Wuhan Topule Biopharmaceutical Co., Ltd
Jilin Chinese Academy of Sciences-yanshen Technology
Aladdin Scientific
Amadis Chemical Company Limited
