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ChemicalBook >> CAS DataBase List >> UCN-01

UCN-01

UCN-01 price.
  • $179 - $4000
  • Product name: UCN-01
  • CAS: 112953-11-4
  • MF: C28H26N4O4
  • MW: 482.53044
  • EINECS:
  • MDL Number:MFCD26960886
  • Synonyms:UCN-01;7-hydroxystaurosporine;KW-2401;(9S)-2,3,10,11,12,13-Hexahydro-3α-hydroxy-10α-methoxy-9-methyl-11α-methylamino-9β,13β-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one;9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lM]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-3-hydroxy-10-Methoxy-9-Methyl-11-(MethylaMino)-, (3R,9S,10R,11R,13R)-;KRX-0601;NSC 638850;UNC 01
Price9 Properties Safety Information Description
9 prices
Selected condition：
Brand
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Cayman Chemical
  • CSNpharm
  • Sigma-Aldrich
Package
  • 0.25MG
  • 500μg
  • 1mg
  • 5mg
  • 10mg
  • 1mg(solution)
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0001444
  • Product description7-HYDROXYSTAUROSPORINE 95.00%
  • Packaging0.25MG
  • Price$218
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC4783
  • Product descriptionUCN-01
  • Packaging1mg(solution)
  • Price$215
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number18130
  • Product descriptionUCN-01 ≥95%
  • Packaging1mg
  • Price$179
  • Updated2024-03-01
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN23871
  • Product descriptionUCN-01
  • Packaging1mg
  • Price$550
  • Updated2021-12-16
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN23871
  • Product descriptionUCN-01
  • Packaging5mg
  • Price$2300
  • Updated2021-12-16
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN23871
  • Product descriptionUCN-01
  • Packaging10mg
  • Price$4000
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberU6508
  • Product descriptionUCN-01 ≥97% (HPLC), powder
  • Packaging1mg
  • Price$228
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number539644
  • Product descriptionUCN-01 A cell-permeable Staurosporine derived anticancer agent that reversibly and ATP-competitively inhibits several protein kinases.
  • Packaging500μg
  • Price$245
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberU6508
  • Product descriptionUCN-01 ≥97% (HPLC), powder
  • Packaging5mg
  • Price$895
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
American Custom Chemicals Corporation KIN0001444 7-HYDROXYSTAUROSPORINE 95.00% 0.25MG $218 2021-12-16 Buy
ApexBio Technology C4783 UCN-01 1mg(solution) $215 2021-12-16 Buy
Cayman Chemical 18130 UCN-01 ≥95% 1mg $179 2024-03-01 Buy
CSNpharm CSN23871 UCN-01 1mg $550 2021-12-16 Buy
CSNpharm CSN23871 UCN-01 5mg $2300 2021-12-16 Buy
CSNpharm CSN23871 UCN-01 10mg $4000 2021-12-16 Buy
Sigma-Aldrich U6508 UCN-01 ≥97% (HPLC), powder 1mg $228 2024-03-01 Buy
Sigma-Aldrich 539644 UCN-01 A cell-permeable Staurosporine derived anticancer agent that reversibly and ATP-competitively inhibits several protein kinases. 500μg $245 2024-03-01 Buy
Sigma-Aldrich U6508 UCN-01 ≥97% (HPLC), powder 5mg $895 2024-03-01 Buy

Properties

Boiling point :705.7±60.0 °C(Predicted)
Density :1.63±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >5mg/mL
form :Tan solid
pka :12.25±0.70(Predicted)
color :light yellow
optical activity :[α]20/D 130 to 160°, c = 0.2 in DMSO

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

UCN-01 is a synthetic derivative of staurosporine with antiproliferative activity against several in vitro and in vivo cancer models. It inhibits a variety of kinases, including Akt, protein kinase C (IC50 = 30 nM), PDK1 (IC50 = 6 nM) and cyclin-dependent kinases (IC50s = 300-600 nM for Cdk1 and Cdk2). UCN-01 arrests tumor cells in the G1/S phase of the cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase Chk1 (IC50 = 7 nM), leading to apoptosis.

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