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ChemicalBook >> CAS DataBase List >> VU0456810

VU0456810

VU0456810 price.
  • $36 - $1800
  • Product name: VU0456810
  • CAS: 1443246-62-5
  • MF: C17H14F2N4O
  • MW: 328.32
  • EINECS:
  • MDL Number:MFCD27977571
  • Synonyms:1-(3,4-Difluorophenyl)-3-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea;CID 56642816;ML297;VU0456810;1-(3,4-DIFLUOROPHENYL)-3-(5-METHYL-2-PHENYLPYRAZOL-3-YL)UREA;ML297, Pubchem: CID 56642816;ML297 (VU0456810);ML 297;ML-297;ML297;VU0456810;VU-0456810;VU 0456810
28 prices
Selected condition:
Brand
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Matrix Scientific
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 10
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 50
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product numberSYN5464
  • Product descriptionML297
  • Packaging50mg
  • Price$547
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1209586
  • Product description1-(3,4-Difluorophenyl)-3-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea 97%
  • Packaging5mg
  • Price$36
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1209586
  • Product description1-(3,4-Difluorophenyl)-3-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea 97%
  • Packaging10mg
  • Price$53
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1209586
  • Product description1-(3,4-Difluorophenyl)-3-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea 97%
  • Packaging25mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1209586
  • Product description1-(3,4-Difluorophenyl)-3-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea 97%
  • Packaging50mg
  • Price$135
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA1209586
  • Product description1-(3,4-Difluorophenyl)-3-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea 97%
  • Packaging250mg
  • Price$334
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC5045
  • Product descriptionML-297
  • Packaging10mg
  • Price$234
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC5045
  • Product descriptionML-297
  • Packaging50mg
  • Price$985
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number14792
  • Product descriptionML-297 ≥98%
  • Packaging1mg
  • Price$49
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14792
  • Product descriptionML-297 ≥98%
  • Packaging5mg
  • Price$216
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14792
  • Product descriptionML-297 ≥98%
  • Packaging10mg
  • Price$380
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number14792
  • Product descriptionML-297 ≥98%
  • Packaging25mg
  • Price$830
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0033056
  • Product descriptionML297 98.70%
  • Packaging5mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0033056
  • Product descriptionML297 98.70%
  • Packaging10mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0033056
  • Product descriptionML297 98.70%
  • Packaging25mg
  • Price$280
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0033056
  • Product descriptionML297 98.70%
  • Packaging50mg
  • Price$420
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific SYN5464 ML297 50mg $547 2021-12-16 Buy
Ambeed A1209586 1-(3,4-Difluorophenyl)-3-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea 97% 5mg $36 2021-12-16 Buy
Ambeed A1209586 1-(3,4-Difluorophenyl)-3-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea 97% 10mg $53 2021-12-16 Buy
Ambeed A1209586 1-(3,4-Difluorophenyl)-3-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea 97% 25mg $90 2021-12-16 Buy
Ambeed A1209586 1-(3,4-Difluorophenyl)-3-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea 97% 50mg $135 2021-12-16 Buy
Ambeed A1209586 1-(3,4-Difluorophenyl)-3-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea 97% 250mg $334 2021-12-16 Buy
ApexBio Technology C5045 ML-297 10mg $234 2021-12-16 Buy
ApexBio Technology C5045 ML-297 50mg $985 2021-12-16 Buy
Cayman Chemical 14792 ML-297 ≥98% 1mg $49 2024-03-01 Buy
Cayman Chemical 14792 ML-297 ≥98% 5mg $216 2024-03-01 Buy
Cayman Chemical 14792 ML-297 ≥98% 10mg $380 2024-03-01 Buy
Cayman Chemical 14792 ML-297 ≥98% 25mg $830 2024-03-01 Buy
ChemScene CS-0033056 ML297 98.70% 5mg $90 2021-12-16 Buy
ChemScene CS-0033056 ML297 98.70% 10mg $150 2021-12-16 Buy
ChemScene CS-0033056 ML297 98.70% 25mg $280 2021-12-16 Buy
ChemScene CS-0033056 ML297 98.70% 50mg $420 2021-12-16 Buy

Properties

Boiling point :377.8±42.0 °C(Predicted)
Density :1.32±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO: soluble15mg/mL, clear
pka :12.54±0.70(Predicted)
form :White powder
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P273 Avoid release to the environment.
P501 Dispose of contents/container to..…

Description

G protein-regulated inwardly rectifying potassium (GIRK1-4) channels are a family of Kir3.1-Kir3.4 ion channels that modulate cell excitability. The four different GIRK subunits are composed in different homo- and heterotetrameric combinations, which are expressed with regional specificity throughout the central nervous system and in the periphery. ML-297 is a selective GIRK1/2 activator (EC50s = 0.16 and 1.8 μM for GIRK1/2 and GIRK1/4, respectively, and is completely inactive at GIRK2/3). In two different mouse models of epilepsy, ML-297 at 60 mg/kg was shown to delay seizure onset and to prevent convulsions.

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