XL413 (hydrochloride)
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- $30 - $900
- Product name: XL413 (hydrochloride)
- CAS: 2062200-97-7
- MF: C14H13Cl2N3O2
- MW: 326.18
- EINECS:
- MDL Number:
- Synonyms:XL-413 hydrochloride,XL413 hydrochloride
8 prices
Selected condition：
Brand
- Cayman Chemical
- ChemScene
Package
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- ManufacturerCayman Chemical
- Product number24906
- Product descriptionXL413 (hydrochloride) ≥98%
- Packaging5mg
- Price$119
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number24906
- Product descriptionXL413 (hydrochloride) ≥98%
- Packaging10mg
- Price$223
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number24906
- Product descriptionXL413 (hydrochloride) ≥98%
- Packaging25mg
- Price$444
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number24906
- Product descriptionXL413 (hydrochloride) ≥98%
- Packaging50mg
- Price$748
- Updated2023-06-20
- Buy
- ManufacturerChemScene
- Product numberCS-1957
- Product descriptionXL413 hydrochloride 99.72%
- Packaging5mg
- Price$144
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1957
- Product descriptionXL413 hydrochloride 99.72%
- Packaging10mg
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1957
- Product descriptionXL413 hydrochloride 99.72%
- Packaging50mg
- Price$600
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-1957
- Product descriptionXL413 hydrochloride 99.72%
- Packaging100mg
- Price$900
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Cayman Chemical | 24906 | XL413 (hydrochloride) ≥98% | 5mg | $119 | 2024-03-01 | Buy |
| Cayman Chemical | 24906 | XL413 (hydrochloride) ≥98% | 10mg | $223 | 2024-03-01 | Buy |
| Cayman Chemical | 24906 | XL413 (hydrochloride) ≥98% | 25mg | $444 | 2024-03-01 | Buy |
| Cayman Chemical | 24906 | XL413 (hydrochloride) ≥98% | 50mg | $748 | 2023-06-20 | Buy |
| ChemScene | CS-1957 | XL413 hydrochloride 99.72% | 5mg | $144 | 2021-12-16 | Buy |
| ChemScene | CS-1957 | XL413 hydrochloride 99.72% | 10mg | $200 | 2021-12-16 | Buy |
| ChemScene | CS-1957 | XL413 hydrochloride 99.72% | 50mg | $600 | 2021-12-16 | Buy |
| ChemScene | CS-1957 | XL413 hydrochloride 99.72% | 100mg | $900 | 2021-12-16 | Buy |
Properties
storage temp. :Store at -20°C
solubility :DMSO:0.2(Max Conc. mg/mL);0.613(Max Conc. mM)
PBS (pH:7.2):10.0(Max Conc. mg/mL);30.66(Max Conc. mM) form :A crystalline solid
color :White to off-white
solubility :DMSO:0.2(Max Conc. mg/mL);0.613(Max Conc. mM)
PBS (pH:7.2):10.0(Max Conc. mg/mL);30.66(Max Conc. mM) form :A crystalline solid
color :White to off-white
Safety Information
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Description
XL413 is a potent inhibitor of Cdc7 (IC50 = 3.4 nM). It is >60, >10, and >300-fold selective for Cdc7 over CK2, PIM1, and a panel of over 100 protein kinases, respectively. XL413 inhibits the growth of MDA-MB-231T and COLO 205 cells (IC50s = 118 and 140 nM, respectively). It inhibits Cdc7-specific phosphorylation of mini-chromosome maintenance protein (MCM2) and induces cell cycle accumulation in the S and G2 phases in MDA-MB-231T and COLO 205 cells that overexpress Cdc7. In vivo, XL413 inhibits MCM2 phosphorylation (ED50 = <3 mg/kg) and reduces tumor growth in a COLO 205 mouse xenograft model when administered orally at doses of 10, 30, and 100 mg/kg.Suppliers and manufacturers
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Shanghai hongqu biomedical technology co. LTD
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