siomycin A
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- $396 - $582
- Product name: siomycin A
- CAS: 12656-09-6
- MF: C71H81N19O18S5
- MW: 1648.84
- EINECS:
- MDL Number:
- Synonyms:Antibiotic 6741-21;Mutabillicin;Mutabilycin;siomycin A;Mutabilycin, SporangioMycin, 6741-21, Mutabillicin;AKFVOKPQHFBYCA-OFENGFFDSA-N;Alaninamide, N-[(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-valyl-2,3-didehydroalanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexa...;Salomycin A
3 prices
Selected condition:
Brand
- Cayman Chemical
- TRC
- Usbiological
Package
- 500ug
- 500μg
- 1000μg
- ManufacturerCayman Chemical
- Product number15378
- Product descriptionSiomycin A ≥95%
- Packaging500μg
- Price$396
- Updated2024-03-01
- Buy
- ManufacturerTRC
- Product numberS497053
- Product descriptionSiomycin A
- Packaging1000μg
- Price$545
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product numberS1013-86W
- Product descriptionSiomycin A
- Packaging500ug
- Price$582
- Updated2021-12-16
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Cayman Chemical | 15378 | Siomycin A ≥95% | 500μg | $396 | 2024-03-01 | Buy |
TRC | S497053 | Siomycin A | 1000μg | $545 | 2021-12-16 | Buy |
Usbiological | S1013-86W | Siomycin A | 500ug | $582 | 2021-12-16 | Buy |
Properties
Density :1.65±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: complete10 mg/ml, clear, colorless to faintly yellow
form :White solid.
pka :10.43±0.46(Predicted)
storage temp. :-20°C
solubility :DMSO: complete10 mg/ml, clear, colorless to faintly yellow
form :White solid.
pka :10.43±0.46(Predicted)
Safety Information
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Description
The mammalian transcription factor forkhead box M1 (FoxM1) is induced during G1 phase, with expression continuing through S phase and mitosis. Siomycin A is a peptide thiazole antibiotic, first isolated from S. sioyaensis, that interacts with the 23S rRNA of bacteria. It inhibits FoxM1 (IC50 = ~5 μM), preventing the expression of FoxM1-regulated genes, which includes FoxM1 itself. Through this mechanism, siomycin A prevents proliferation and induces apoptosis in certain types of stem cells as well as cancer cells.Related product price
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