TIQ-A
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- $32 - $1732.5
- Product name: TIQ-A
- CAS: 420849-22-5
- MF: C11H7NOS
- MW: 201.24
- EINECS:
- MDL Number:MFCD06407947
- Synonyms:Thieno[2,3-c]isoquinolin-5(4H)-one;TIQ-A,poly ADP ribose polymerase,ADP-ribosyltransferase,TIQA,Inhibitor,PARP,TIQ A,inhibit,tankyrases,ADP-ribosylation,poly-ART
12 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- Cayman Chemical
- Sigma-Aldrich
- TRC
Package
- 500μg
- 1mg
- 5mg
- 10mg
- 50MG
- ManufacturerAK Scientific
- Product number3747BB
- Product description4H-Thieno[2,3-c]isoquinolin-5-one
- Packaging1mg
- Price$160
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number3747BB
- Product description4H-Thieno[2,3-c]isoquinolin-5-one
- Packaging5mg
- Price$353
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001037
- Product descriptionTIQ-A 95.00%
- Packaging1MG
- Price$160.65
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001037
- Product descriptionTIQ-A 95.00%
- Packaging5MG
- Price$756.25
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001037
- Product descriptionTIQ-A 95.00%
- Packaging50MG
- Price$1732.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16112
- Product descriptionTIQ-A ≥98%
- Packaging500μg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16112
- Product descriptionTIQ-A ≥98%
- Packaging1mg
- Price$57
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16112
- Product descriptionTIQ-A ≥98%
- Packaging5mg
- Price$230
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16112
- Product descriptionTIQ-A ≥98%
- Packaging10mg
- Price$396
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberT2825
- Product descriptionTIQ-A ≥98% (HPLC), solid
- Packaging1mg
- Price$109
- Updated2022-05-15
- Buy
- ManufacturerSigma-Aldrich
- Product numberT2825
- Product descriptionTIQ-A ≥98% (HPLC), solid
- Packaging5mg
- Price$365
- Updated2022-05-15
- Buy
- ManufacturerTRC
- Product numberT445100
- Product descriptionTIQ-A
- Packaging1mg
- Price$45
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 3747BB | 4H-Thieno[2,3-c]isoquinolin-5-one | 1mg | $160 | 2021-12-16 | Buy |
| AK Scientific | 3747BB | 4H-Thieno[2,3-c]isoquinolin-5-one | 5mg | $353 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001037 | TIQ-A 95.00% | 1MG | $160.65 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001037 | TIQ-A 95.00% | 5MG | $756.25 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001037 | TIQ-A 95.00% | 50MG | $1732.5 | 2021-12-16 | Buy |
| Cayman Chemical | 16112 | TIQ-A ≥98% | 500μg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 16112 | TIQ-A ≥98% | 1mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 16112 | TIQ-A ≥98% | 5mg | $230 | 2024-03-01 | Buy |
| Cayman Chemical | 16112 | TIQ-A ≥98% | 10mg | $396 | 2024-03-01 | Buy |
| Sigma-Aldrich | T2825 | TIQ-A ≥98% (HPLC), solid | 1mg | $109 | 2022-05-15 | Buy |
| Sigma-Aldrich | T2825 | TIQ-A ≥98% (HPLC), solid | 5mg | $365 | 2022-05-15 | Buy |
| TRC | T445100 | TIQ-A | 1mg | $45 | 2021-12-16 | Buy |
Properties
Melting point :256-258°C
Boiling point :282.2±9.0 °C(Predicted)
Density :1.358±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 16 mg/mL, soluble
pka :13.04±0.20(Predicted)
form :solid
color :Light green to green
Boiling point :282.2±9.0 °C(Predicted)
Density :1.358±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 16 mg/mL, soluble
pka :13.04±0.20(Predicted)
form :solid
color :Light green to green
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
Poly(ADP-ribose) polymerase 1 (PARP1) is a critical DNA repair enzyme involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in many pathological conditions including ischemia and reperfusion injury, asthma-related inflammation, and atherogenesis. TIQ-A is a PARP1 inhibitor (IC50 = 450 nM in cultured mouse cortical neurons). It displays neuroprotective effects in cultured mouse cortical neurons injured by oxygen-glucose deprivation (IC50 = 0.15 μM). TIQ-A has been used to inhibit eosinophilic infiltration into airways of OVA-challenged mice and to induce the regression of atherosclerotic plaques in high-fat fed apolipoprotein E(-/-) mice.Related product price
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