BI-6C9
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2物価
選択条件：
ブランド
- Sigma-Aldrich Japan
パッケージ
- 1mg
- 5mg
- 生産者Sigma-Aldrich Japan
- 製品番号B0186
- 製品説明 ≥97% (HPLC), solid
- 英語製品説明BI-6C9 ≥97% (HPLC), solid
- 包装単位1mg
- 価格￥19200
- 更新しました2024-03-01
- 購入
- 生産者Sigma-Aldrich Japan
- 製品番号B0186
- 製品説明 ≥97% (HPLC), solid
- 英語製品説明BI-6C9 ≥97% (HPLC), solid
- 包装単位5mg
- 価格￥64800
- 更新しました2024-03-01
- 購入
| 生産者 | 製品番号 | 製品説明 | 包装単位 | 価格 | 更新時間 | 購入 |
|---|---|---|---|---|---|---|
| Sigma-Aldrich Japan | B0186 | ≥97% (HPLC), solid BI-6C9 ≥97% (HPLC), solid |
1mg | ￥19200 | 2024-03-01 | 購入 |
| Sigma-Aldrich Japan | B0186 | ≥97% (HPLC), solid BI-6C9 ≥97% (HPLC), solid |
5mg | ￥64800 | 2024-03-01 | 購入 |
プロパティ
比重(密度) :1.36±0.1 g/cm3(Predicted)
貯蔵温度 :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
溶解性 :DMSO: 24 mg/mL, soluble
外見 :solid
酸解離定数(Pka) :11.58±0.50(Predicted)
色 :off-white
貯蔵温度 :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
溶解性 :DMSO: 24 mg/mL, soluble
外見 :solid
酸解離定数(Pka) :11.58±0.50(Predicted)
色 :off-white
安全情報
| 絵表示(GHS): |
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| 危険有害性情報: |
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| 注意書き: |
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説明
BH3-interacting domain (Bid) is cleaved by caspase-8 to produce the truncated protein tBid, which facilitates cytochrome c release from mitochondria and drives apoptosis. BI-6C9 is an inhibitor of tBid (Kd = 20 μM), blocking the release of both cytochrome c and second mitochondria-derived activator of caspase from mitochondria. It prevents apoptosis in neurons treated with glutamate or oxygen-glucose deprivation. BI-6C9 (10 μM) also inhibits the nuclear translocation of apoptosis-inducing factor AIF, preventing the death of ovarian OVCAR-3 cancer cells induced by IFN-α2a.供給者とメーカー
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