Picolinamide

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Picolinamide Basic information

Product Name:	Picolinamide
Synonyms:	alpha-Picolinic acid amide;Picolinic acid amide;Picolinoylamide;Pyridine-2-carboxylicamide;2-PYRIDINECARBOXAMIDE;2-PICOLINAMIDE;PICOLINAMIDE;PYRIDINE-2-CARBOXYLIC ACID AMIDE
CAS:	1452-77-3
MF:	C6H6N2O
MW:	122.12
EINECS:	215-921-5
Product Categories:	Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Heterocyclic Compounds
Mol File:	1452-77-3.mol

Picolinamide Chemical Properties

Melting point	110 °C (dec.)(lit.)
Boiling point	143 °C / 20mmHg
density	1.2236 (rough estimate)
refractive index	1.5350 (estimate)
storage temp.	Inert atmosphere,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
pka	pK1: 2.10(+1) (20°C)
form	Solid
color	White to Off-White
BRN	109617
CAS DataBase Reference	1452-77-3(CAS DataBase Reference)
EPA Substance Registry System	2-Pyridinecarboxamide (1452-77-3)

Safety Information

MSDS Information

Provider	Language
SigmaAldrich	English
ALFA	English

Picolinamide Usage And Synthesis

Description	Picolinamide is an inhibitor of Poly(ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.
Uses	Picolinamide is a nicotinic acid derivative for prevention and treatment of cancer by activating RUNX3 gene.
Preparation	Picolinamide is prepared by processes that include coupling together a 4-methoxy-3-acyloxypicolinic acid with key 2-amino-L-alaninate esters derived from substituted 2-phenylethanols.
Pharmacology	picolinamide is a poly (adp-ribose) synthetase (parp) inhibitor. Parp inhibitors, a group of pharmacological inhibitors of the enzyme poly adp ribose polymerase (parp), are developed for multiple indications, especially for the treatment of cancer.

Picolinamide Preparation Products And Raw materials

Raw materials	Sodium hydroxide-->Sulfuric acid-->Dichloromethane-->Potassium carbonate-->Hydrogen peroxide-->Dimethyl sulfoxide-->2-Cyanopyridine-->Methanol-->Carbon dioxide-->Dimethyl carbonate-->Methyl picolinate
Preparation Products	2-Pyridinecarboxamide, N-cyclohexyl-

Tag:Picolinamide(1452-77-3) Related Product Information

PYRIDINE-2-CARBOXYLIC ACID HYDRAZIDE Isonicotinamide Nicotinamide 2,4-Pyridinedicarboxylic acid, 2-Methyl ester Pyridine hydrofluoride 4-AMIDINOPYRIDINE HYDROCHLORIDEPYRIDINE-4-CARBOXIMIDAMIDE HYDROCHLORIDE 3-(2-PYRIDYL)ACRYLIC ACID Nicotinic acid NAD+ β-Nicotinamide Mononucleotide Nicotinamide-N-oxide 3-Cyanopyridine Pyridine-3-sulfonyl chloride hydrochloride PYRIDINE-3-SULFONIC ACID SODIUM SALT PYRIDINE-2,4-DICARBONITRILE Pyridine, 4-(diethylboryl)- Pyridine, 3-(3-ethoxyandrosta-5,16-dien-17-yl)- Pyridine, 3-[3-(1-methylethoxy)androsta-5,16-dien-17-yl]-