| Company Name: |
Toronto Research Chemicals Inc.
|
| Tel: |
+1 (416) 665-9696 |
| Email: |
info@trc-canada.com |
| Products Intro: |
Cas:1452-77-3
ProductName:Picolinamide
Brand:trc-canada | Product Number:P437000
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- Picolinamide
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- $29.00 / 1g
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2024-11-19
- CAS:1452-77-3
- Min. Order:
- Purity: 99.60%
- Supply Ability: 10g
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| | Picolinamide Basic information |
| | Picolinamide Chemical Properties |
| Melting point | 110 °C (dec.)(lit.) | | Boiling point | 143 °C / 20mmHg | | density | 1.2236 (rough estimate) | | refractive index | 1.5350 (estimate) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | pK1: 2.10(+1) (20°C) | | form | Solid | | color | White to Off-White | | BRN | 109617 | | CAS DataBase Reference | 1452-77-3(CAS DataBase Reference) | | EPA Substance Registry System | 2-Pyridinecarboxamide (1452-77-3) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39 | | WGK Germany | 3 | | TSCA | Yes | | HS Code | 29333990 |
| | Picolinamide Usage And Synthesis |
| Description | Picolinamide is an inhibitor of Poly(ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.
| | Uses |
Picolinamide is a nicotinic acid derivative for prevention and treatment of cancer by activating RUNX3 gene.
| | Preparation |
Picolinamide is prepared by processes that include coupling together a 4-methoxy-3-acyloxypicolinic acid with key 2-amino-L-alaninate esters derived from substituted 2-phenylethanols.
| | Pharmacology | picolinamide is a poly (adp-ribose) synthetase (parp) inhibitor. Parp inhibitors, a group of pharmacological inhibitors of the enzyme poly adp ribose polymerase (parp), are developed for multiple indications, especially for the treatment of cancer.
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| | Picolinamide Preparation Products And Raw materials |
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