Company Name: |
Toronto Research Chemicals Inc.
|
Tel: |
+1 (416) 665-9696 |
Email: |
info@trc-canada.com |
Products Intro: |
Cas:1452-77-3
ProductName:Picolinamide
Brand:trc-canada | Product Number:P437000
|
- Picolinamide
-
- $29.00 / 1g
-
2024-11-19
- CAS:1452-77-3
- Min. Order:
- Purity: 99.60%
- Supply Ability: 10g
|
| Picolinamide Basic information |
| Picolinamide Chemical Properties |
Melting point | 110 °C (dec.)(lit.) | Boiling point | 143 °C / 20mmHg | density | 1.2236 (rough estimate) | refractive index | 1.5350 (estimate) | storage temp. | Inert atmosphere,Room Temperature | solubility | DMSO (Slightly), Methanol (Slightly) | form | Solid | pka | pK1: 2.10(+1) (20°C) | color | White to Off-White | BRN | 109617 | CAS DataBase Reference | 1452-77-3(CAS DataBase Reference) | EPA Substance Registry System | 2-Pyridinecarboxamide (1452-77-3) |
Hazard Codes | Xi | Risk Statements | 36/37/38 | Safety Statements | 26-37/39 | WGK Germany | 3 | TSCA | Yes | HS Code | 29333990 |
| Picolinamide Usage And Synthesis |
Description | Picolinamide is an inhibitor of Poly(ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.
| Uses |
Picolinamide is a nicotinic acid derivative for prevention and treatment of cancer by activating RUNX3 gene.
| Preparation |
Picolinamide is prepared by processes that include coupling together a 4-methoxy-3-acyloxypicolinic acid with key 2-amino-L-alaninate esters derived from substituted 2-phenylethanols.
| Pharmacology | picolinamide is a poly (adp-ribose) synthetase (parp) inhibitor. Parp inhibitors, a group of pharmacological inhibitors of the enzyme poly adp ribose polymerase (parp), are developed for multiple indications, especially for the treatment of cancer.
|
| Picolinamide Preparation Products And Raw materials |
|