L-墨蝶呤
中文名称 | L-墨蝶呤 |
---|---|
中文同义词 | S-(-)-2-氨基-7,8-二氢-6-(2-羟基-1-氧代丙基)-4(1H)-蝶啶酮;墨蝶呤;L-墨蝶呤;乌贼乙素(L-乌贼乙素);墨蝶蛉(L-墨蝶蛉);(S)-2-氨基-6-(2-羟基丙酰基)-7,8-二氢蝶啶-4(3H)-酮 |
英文名称 | L-SEPIAPTERIN |
英文同义词 | (S)-2-aMino-6-(2-hydroxypropanoyl)-7,8-dihydropteridin-4(1H)-one;(S)-2-AMino-6-(2-hydroxypropanoyl)-7,8-dihydropteridin-4(3H)-one;Sepiapterin solid;S(-)-2-AMINO-7,8-DIHYDRO-6-(2-HYDROXY-1-OXOPROPYL)-4(1H)-PTERIDINONE;L-SEPIAPTERIN DIHYDRATE;2-AMINO-7,8-DIHYDRO-6-(2S-HYDROXY-1-OXOPROPYL)-4(1H)-PTERIDINONE;SEPIAPTERIN (L-SEPIAPTERIN) COFACTOR OF NITRIC OX;L -SEPIAPTERIN DIHYDRATE 99+% |
CAS号 | 17094-01-8 |
分子式 | C9H11N5O3 |
分子量 | 237.22 |
EINECS号 | |
相关类别 | 对照品 |
Mol文件 | 17094-01-8.mol |
结构式 | ![]() |
L-墨蝶呤 性质
熔点 | >270 °C (dec.) |
---|---|
沸点 | 448.1±55.0 °C(Predicted) |
密度 | 1.86±0.1 g/cm3(Predicted) |
储存条件 | -20°C |
溶解度 | 二甲基亚砜:27 毫克/毫升 |
形态 | 固体 |
酸度系数(pKa) | 12.33±0.20(Predicted) |
颜色 | 粘黄色 |
稳定性 | 感光 |
CAS 数据库 | 17094-01-8 |
Human Endogenous Metabolite
|
L-Sepiapterin (Sepiapterin) (0.1-10 μM; 24 hpurs) Iinduces cell proliferation in a dose-dependent manner.
L-Sepiapterin (1-50 μM; 20 minutes) significantly inhibits the phosphorylation of VEGF-A-induced (50 ng/ml) p70
S6K
.
L-Sepiapterin inhibits VEGF-A-induced cell proliferation and migration through NO-independent mechanism.
Cell Proliferation Assay
Cell Line: | SKOV-3 cells |
Concentration: | 0.1, 1, 10 μM |
Incubation Time: | 24 hours |
Result: | Induced cell proliferation in a dose-dependent manner. |
Sepiapterin (10 mg/kg; p.o. (powder chow); daily for or 8 weeks) significantly improves the relaxation to Ach in small mesenteric arteries (SMA) from db/db mice.
Animal Model: | Male C57BL/KsJ diabetic mice (db/db) |
Dosage: | 10 mg/kg |
Administration: | P.o. (powder chow); daily for or 8 weeks |
Result: | Significantly improved the relaxation to Ach in SMA from db/db mice. |
安全信息
安全说明 | 24/25 |
---|---|
WGK Germany | 3 |
提供商 | 语言 |
---|---|
英文
|
|
英文
|
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-112234 | L-墨蝶呤 L-Sepiapterin | 17094-01-8 | 1mg | 9000元 |