ascochlorin

ascochlorin Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:Ascochlorin;Ilicicolin D
CAS:26166-39-2
Purity:98.00% Package:100 mg;500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: BOC Sciences
Tel: 16314854226; +16314854226
Email: inquiry@bocsci.com
Products Intro: Product Name:Ascochlorin
CAS:26166-39-2
Purity:>98% Remarks:BOC Sciences also provides custom synthesis services for Ascochlorin.
Company Name: Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel: +86-057181025280; +8617767106207
Email: sales@molcore.com
Products Intro: Product Name:Ascochlorin
CAS:26166-39-2
Purity:NLT 98% Remarks:MC545084
Company Name: TargetMol Chemicals Inc.
Tel:
Email: support@targetmol.com
Products Intro: Product Name:Ascochlorin
CAS:26166-39-2
Package:500μg;720USD
Company Name: Aladdin Scientific
Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:Ascochlorin
CAS:26166-39-2
Purity:>95% Package:$341.9/500μg;Bulk package Remarks:>95%

ascochlorin manufacturers

  • Ascochlorin
  • Ascochlorin pictures
  • $720.00 / 500μg
  • 2024-10-24
  • CAS:26166-39-2
  • Min. Order:
  • Purity:
  • Supply Ability: 10g
ascochlorin Basic information
Product Name:ascochlorin
Synonyms:3-Chloro-4,6-dihydroxy-2-methyl-5-[(2E,4E)-3-methyl-5-[(1R)-1β,2β,6β-trimethyl-3-oxocyclohexyl]-2,4-pentadienyl]benzaldehyde;Ilicicolin D;3-Chloro-4,6-dihydroxy-2-methyl-5-(3-methyl-5-(1,2,6-trimethyl-3-oxocyclohexyl)-2,4-pentadienyl)benzaldehyde (1R-(1alpha(2E,4E),2beta,6beta))-;Antibiotic ll-Z1272 gamma;ascochlorin;Benzaldehyde, 3-chloro-4,6-dihydroxy-2-methyl-5-(3-methyl-5-(1,2,6-trimethyl-3-oxocyclohexyl)-2,4-pentadienyl)-, (1R-(1alpha(2E,4E),2beta,6beta))-;beta-Resorcylaldehyde, 5-chloro-6-methyl-3-(3-methyl-5-(1,2,6-trimethyl-3-oxocyclohexyl)-2,4-pentadienyl)-, (E,E)-;Ll-Z 1272 gamma
CAS:26166-39-2
MF:C23H29ClO4
MW:404.931
EINECS:
Product Categories:
Mol File:26166-39-2.mol
ascochlorin Structure
ascochlorin Chemical Properties
Melting point 172-174 °C
Boiling point 556.9±39.0 °C(Predicted)
density 1.199±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: soluble
form A powder
pka6.26±0.50(Predicted)
Safety Information
WGK Germany 3
Toxicitymouse,LD50,intraperitoneal,20mg/kg (20mg/kg),Journal of Antibiotics. Vol. 21, Pg. 539, 1968.
MSDS Information
ascochlorin Usage And Synthesis
UsesAscochlorin is an isoprenoid antibiotic and antiviral that has diverse effects on mammalian cells. It suppresses PMA-induced invasion in renal carcinoma cells (IC50 = ~10 μM) by inhibiting the expression of matrix metalloproteinase-9. At 2 μM, ascochlorin profoundly increases the expression of p53 by increasing protein stability in cancer cells, and, at 50 μm, it inhibits signaling through STAT3. Ascochlorin also binds and inhibits the mitochondrial cytochrome bc1 complex, blocking reduction of cytochrome b by ubiquinone.[Cayman Chemical]
UsesAscochlorin is an antitumor fungal metabolite which specifically inhibits matrix metalloproteinase-9 (MMP-9) activity through suppression of activator protein-1 (AP-1)-dependent induction of MMP-9 gene expression. Via AP-1 suppression, ascochlorin selectively kills MX-1 cells, a human breast cancer cell line lacking estrogen receptors. Ascochlorin also shows activity against Newcastle disease and herpes simplex viruses.
DefinitionChEBI: Ascochlorin is a dihydroxybenzaldehyde that is 2,4-dihydroxybenzaldehyde which is substituted by a (1E,3E)-3-methyl-1-[(1R,2R,6R)-1,2,6-trimethyl-3-oxocyclohexyl]penta-1,3-dien-5-yl group at position 3, chlorine at position 5, and a methyl group at position 6. A meroterpenoid produced by several fungi including Ascochyta viciae. It exhibits anticancer, antifungal and antiprotozoal activities. It has a role as an antineoplastic agent, a fungal metabolite, an antifungal agent, an antiprotozoal drug and an angiogenesis inhibitor. It is a dihydroxybenzaldehyde, a member of monochlorobenzenes, an olefinic compound, a member of resorcinols, a meroterpenoid, a sesquiterpenoid and a member of cyclohexanones. It is a conjugate acid of an ascochlorin(1-).
ascochlorin Preparation Products And Raw materials
Tag:ascochlorin(26166-39-2) Related Product Information
LF163892 MONOHYDRATE A-1331852 5-METHYL-2-[(1R,6R)-3-METHYL-6-(1-METHYLETHENYL)-2-CYCLOHEXEN-1-YL]-1,3-BENZENEDIOL 2-ALLYL-6-CHLOROPHENOL ILICICOLIN F ascochlorin