地司特泰
| 中文名称 | 地司特泰 |
|---|---|
| 中文同义词 | 地司特泰;L-苏氨酰-L-丝氨酰-L-亮氨酰-L-ALPHA-天冬氨酰-L-丙氨酰-L-丝氨酰-L-异亮氨酰-L-异亮氨酰-L-色氨酰-L-丙氨酰-L-蛋氨酰-L-蛋氨酰-L-谷氨酰胺酰-L-天冬酰胺;地司特肽;TGF-Β1抑制剂(DISITERTIDE);H-THR-SER-LEU-ASP-ALA-SER-ILE-ILE-TRP-ALA-MET-MET-GLN-ASN-OH;抑制剂多肽DISITERTIDE |
| 英文名称 | Disitertide |
| 英文同义词 | disitertide;L-Threonyl-L-seryl-L-leucyl-L-alpha-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-L-asparagine;P144 Peptide;P144;P144 PEPTIDE;TSLDASIIWAMMQN;DISITERTIDE, >98%;Disitertide,P144,P144 Peptide, >98%;L-Asparagine, L-threonyl-L-seryl-L-leucyl-L-α-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl- |
| CAS号 | 272105-42-7 |
| 分子式 | C68H109N17O22S2 |
| 分子量 | 1580.84 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂 |
| Mol文件 | 272105-42-7.mol |
| 结构式 |  |
地司特泰 性质
| 沸点 | 1968.7±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.327 |
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO：≥ 200 mg/mL (126.52 mM)；水：< 0.1 mg/mL（不溶） |
| 酸度系数(pKa) | 3.15±0.10(Predicted) |
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
| InChIKey | IUYPEUHIWDMJLM-INGCBPSVNA-N |
Disitertide (100 μg/mL) suppresses the protein expression levels of PI3K and p-Akt, and induce the protein expression of Bax in MC3T3-E1 cells.
Disitertide (TGF-β1 inhibitor) abrogates the MACC1- AS1 expression in GC cells, suggesting that targeting TGFβ signaling pathway may be a potential strategy to inhibit MSC-induced stemness and chemoresistance.
Disitertide (P144, 10 μg/mL to 200 μg/mL) affects proliferation, induces apoptosis as well as anoikis in A172 and U-87 MG GBM cell lines.
Western Blot Analysis
| Cell Line: | Mouse embryo osteoblast precursor MC3T3-E1 cells. |
| Concentration: | 100 μg/mL. |
| Incubation Time: | 4 h. |
| Result: | Significantly suppressed the protein expression levels of PI3K and p-Akt, and induce the protein expression of Bax in MC3T3-E1 cells compared with the miR-590 group. |
Disitertide (Topical application, 300 μg/mL) may promote scar maturation and clinical improvement of hypertrophic scar morphology features in an “in vivo” model in nude mice after two weeks of treatment.
| Animal Model: |
Human hypertrophic scars were implanted in 60 nude mice.
|
| Dosage: | 300 μg/mL was added the Lipogel. |
| Administration: | Topical application daily administered. |
| Result: | Successful shedding was achieved in 83,3% of the xenografts. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2022/09/18 | HY-P0118 | 地司特泰 Disitertide | 272105-42-7 | 5mg | 3500元 |
| 2022/09/18 | HY-P0118 | 地司特泰 Disitertide | 272105-42-7 | 10mg | 5600元 |