地司特泰
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- CAS号:
- 272105-42-7
- 英文名:
- Disitertide
- 英文别名:
- disitertide;P144 Peptide;TSLDASIIWAMMQN;P144;P144 PEPTIDE;DISITERTIDE, >98%;Disitertide,P144,P144 Peptide, >98%;DisitertideH-Gly-Arg-Gly-Asp-Asn-Pro-OH;L-Asparagine,L-threonyl-L-seryl-L-leucyl-L-a-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-;L-Asparagine, L-threonyl-L-seryl-L-leucyl-L-α-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-;L-Threonyl-L-seryl-L-leucyl-L-alpha-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-L-asparagine
- 中文名:
- 地司特泰
- 中文别名:
- 地司特肽;地司特泰;化合物 DISITERTIDE;抑制剂多肽DISITERTIDE;TGF-Β1抑制剂(DISITERTIDE);H-THR-SER-LEU-ASP-ALA-SER-ILE-ILE-TRP-ALA-MET-MET-GLN-ASN-OH;L-苏氨酰-L-丝氨酰-L-亮氨酰-L-ALPHA-天冬氨酰-L-丙氨酰-L-丝氨酰-L-异亮氨酰-L-异亮氨酰-L-色氨酰-L-丙氨酰-L-蛋氨酰-L-蛋氨酰-L-谷氨酰胺酰-L-天冬酰胺
- CBNumber:
- CB01518504
- 分子式:
- C68H109N17O22S2
- 分子量:
- 1580.84
- MOL File:
- 272105-42-7.mol
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地司特泰化学性质
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沸点:
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1968.7±65.0 °C(Predicted)
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密度:
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1.327
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : ≥ 200 mg/mL (126.52 mM);Water : < 0.1 mg/mL (insoluble)
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酸度系数(pKa):
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3.15±0.10(Predicted)
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形态:
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Solid
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颜色:
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White to off-white
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InChIKey:
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IUYPEUHIWDMJLM-INGCBPSVNA-N
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地司特泰性质、用途与生产工艺
Disitertide (P144) TFA 是转化生长因子 TGFβ1 的多肽抑制剂，特异性的阻断其与受体间的相互作用。Disitertide (P144) 也是PI3K 的抑制剂和凋亡 (apoptosis) 诱导剂。
Disitertide (100 μg/mL) suppresses the protein expression levels of PI3K and p-Akt, and induce the protein expression of Bax in MC3T3-E1 cells.
Disitertide (TGF-β1 inhibitor) abrogates the MACC1- AS1 expression in GC cells, suggesting that targeting TGFβ signaling pathway may be a potential strategy to inhibit MSC-induced stemness and chemoresistance.
Disitertide (P144, 10 μg/mL to 200 μg/mL) affects proliferation, induces apoptosis as well as anoikis in A172 and U-87 MG GBM cell lines.
Western Blot Analysis
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Cell Line:
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Mouse embryo osteoblast precursor MC3T3-E1 cells.
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Concentration:
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100 μg/mL.
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Incubation Time:
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4 h.
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Result:
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Significantly suppressed the protein expression levels of PI3K and p-Akt, and induce the protein expression of Bax in MC3T3-E1 cells compared with the miR-590 group.
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Disitertide (Topical application, 300 μg/mL) may promote scar maturation and clinical improvement of hypertrophic scar morphology features in an “in vivo” model in nude mice after two weeks of treatment.
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Animal Model:
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Human hypertrophic scars were implanted in 60 nude mice.
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Dosage:
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300 μg/mL was added the Lipogel.
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Administration:
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Topical application daily administered.
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Result:
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Successful shedding was achieved in 83,3% of the xenografts.
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地司特泰
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2022/09/18 | HY-P0118 | 地司特泰
Disitertide | 272105-42-7 | 5mg | 3500元 |
| 2022/09/18 | HY-P0118 | 地司特泰
Disitertide | 272105-42-7 | 10mg | 5600元 |
272105-42-7, 地司特泰 相关搜索:
- 抑制剂
- 多肽合成
- 细胞生物学试剂
- C68H109N17O22S2
- 化合物 DISITERTIDE
- 抑制剂多肽DISITERTIDE
- H-THR-SER-LEU-ASP-ALA-SER-ILE-ILE-TRP-ALA-MET-MET-GLN-ASN-OH
- TGF-Β1抑制剂(DISITERTIDE)
- 地司特肽
- L-苏氨酰-L-丝氨酰-L-亮氨酰-L-ALPHA-天冬氨酰-L-丙氨酰-L-丝氨酰-L-异亮氨酰-L-异亮氨酰-L-色氨酰-L-丙氨酰-L-蛋氨酰-L-蛋氨酰-L-谷氨酰胺酰-L-天冬酰胺
- 地司特泰
- 272105-42-7
- L-Asparagine,L-threonyl-L-seryl-L-leucyl-L-a-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-
- DisitertideH-Gly-Arg-Gly-Asp-Asn-Pro-OH
- L-Asparagine, L-threonyl-L-seryl-L-leucyl-L-α-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-
- Disitertide,P144,P144 Peptide, >98%
- DISITERTIDE, >98%
- TSLDASIIWAMMQN
- P144;P144 PEPTIDE
- P144 Peptide
- L-Threonyl-L-seryl-L-leucyl-L-alpha-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-L-asparagine
- disitertide