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Disitertide

Disitertide structure

CAS No.: 272105-42-7

Chemical Name:: Disitertide

Synonyms: disitertide;P144 Peptide;TSLDASIIWAMMQN;P144;P144 PEPTIDE;DISITERTIDE, >98%;Disitertide,P144,P144 Peptide, >98%;DisitertideH-Gly-Arg-Gly-Asp-Asn-Pro-OH;L-Asparagine,L-threonyl-L-seryl-L-leucyl-L-a-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-;L-Asparagine, L-threonyl-L-seryl-L-leucyl-L-α-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-;L-Threonyl-L-seryl-L-leucyl-L-alpha-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-L-asparagine

CBNumber:: CB01518504

Molecular Formula:: C68H109N17O22S2

Molecular Weight:: 1580.84

MDL Number:

MOL File:: 272105-42-7.mol

MSDS File:: SDS

Last updated:2024-10-23 13:36:13

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Disitertide Properties

Boiling point	1968.7±65.0 °C(Predicted)
Density	1.327
storage temp.	Store at -20°C
solubility	DMSO : ≥ 200 mg/mL (126.52 mM);Water : < 0.1 mg/mL (insoluble)
pka	3.15±0.10(Predicted)
form	Solid
color	White to off-white
InChIKey	IUYPEUHIWDMJLM-INGCBPSVNA-N
FDA UNII	3N988KP8HD

Disitertide price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-5989	Disitertide	272105-42-7	1mg	$132	2021-12-16	Buy
ChemScene	CS-5989	Disitertide	272105-42-7	5mg	$528	2021-12-16	Buy
Biorbyt Ltd	orb611411	Disitertide	272105-42-7	5mg	$544	2021-12-16	Buy
ChemScene	CS-5989	Disitertide	272105-42-7	10mg	$900	2021-12-16	Buy
Biorbyt Ltd	orb611411	Disitertide	272105-42-7	10mg	$912.9	2021-12-16	Buy

Product number	Packaging	Price	Buy
CS-5989	1mg	$132	Buy
CS-5989	5mg	$528	Buy
orb611411	5mg	$544	Buy
CS-5989	10mg	$900	Buy
orb611411	10mg	$912.9	Buy

Disitertide Chemical Properties,Uses,Production

Description

Disitertide is an inhibitor of TGF-β1. It prevents TGF-β1-dependent inhibition of MV1Lu proliferation in vitro and markedly reduces binding of TGF-β1 to its receptors. Disitertide blocks TGF-β1-dependent stimulation of a reporter gene under the control of human α2(I) collagen promoter. Treatment with Disitertide at low doses causes a significant inhibition of HSC activation and a marked reduction in liver fibrosis in a rat model of chronic exposure to CCl4. A dose as low as 70 μg of the 15-mer peptide Disitertide, given to rats (300 g body weight) on alternate days, decreases fibrogenesis significantly during chronic exposure to CCl4.

Biological Activity

Disitertide (P144) TFA is a polypeptide inhibitor of transforming growth factor TGFβ1, specifically blocking its interaction with the receptor. Disitertide (P144) is also an inhibitor of PI3K and an inducer of apoptosis.

in vitro

Disitertide (100 μg/mL) suppresses the protein expression levels of PI3K and p-Akt, and induce the protein expression of Bax in MC3T3-E1 cells.
Disitertide (TGF-β1 inhibitor) abrogates the MACC1- AS1 expression in GC cells, suggesting that targeting TGFβ signaling pathway may be a potential strategy to inhibit MSC-induced stemness and chemoresistance.
Disitertide (P144, 10 μg/mL to 200 μg/mL) affects proliferation,

Western Blot Analysis

Cell Line:	Mouse embryo osteoblast precursor MC3T3-E1 cells.
Concentration:
Concentration:	100 μg/mL.
Incubation Time:	4 h.
Result:	Significantly suppressed the protein expression levels of PI3K and p-Akt, and induced the protein expression of Bax in MC3T3-E1 cells compared with the miR-590 group.

in vivo

Disitertide (Topical application, 300 μg/mL) may promote scar maturation and clinical improvement of hypertrophic scar morphology features in an “in vivo” model in nude mice after two weeks of treatment.

Animal Model:	Human hypertrophic scars were implanted in 60 nude mice.
Dosage:	300 μg/mL was added the Lipogel.
Administration:	Topical application daily administered.
Result:	Successful shedding was achieved in 83,3% of the xenografts.

storage

Store at -20°C

Disitertide Preparation Products And Raw materials

Raw materials

Preparation Products

Disitertide Suppliers

Global( 52)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19741	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10310	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32072	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30241	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38465	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49979	58
Zhejiang Hangyu API Co., Ltd	+8617531972939	anna@api-made.com	China	2943	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33338	58

Supplier	Advantage
BOC Sciences	58
Shenzhen Nexconn Pharmatechs Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Zhejiang J&C Biological Technology Co.,Limited	58
TargetMol Chemicals Inc.	58
GIHI CHEMICALS CO.,LIMITED	58
Zhejiang Hangyu API Co., Ltd	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58

View Lastest Price from Disitertide manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-10-24	Disitertide 272105-42-7	US $443.00 / mg			10g	TargetMol Chemicals Inc.

Disitertide
272105-42-7
US $443.00 / mg
TargetMol Chemicals Inc.

272105-42-7(Disitertide)Related Search:

L-Alanyl-L-Glutamine Diethylstilbestrol EC 2.3.2.2 L-Asparagine FMOC-ASN(TRT)-OPFP

L-Glutamine Disitertide

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disitertide L-Threonyl-L-seryl-L-leucyl-L-alpha-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-L-asparagine P144 Peptide P144;P144 PEPTIDE TSLDASIIWAMMQN DISITERTIDE, >98% Disitertide,P144,P144 Peptide, >98% L-Asparagine, L-threonyl-L-seryl-L-leucyl-L-α-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl- DisitertideH-Gly-Arg-Gly-Asp-Asn-Pro-OH L-Asparagine,L-threonyl-L-seryl-L-leucyl-L-a-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl- 272105-42-7 C68H109N17O22S2