886563-25-3
| 中文名称 | 886563-25-3 |
|---|---|
| 中文同义词 | 化合物 T13402 |
| 英文名称 | ZK-261991 |
| 英文同义词 | ZK-261991;ZK261991(ZK991);ZK 991;ZK261991;ZK-261991;ZK 261991;ZK-991;ZK 991;ZK-991;Benzamide, 2-[[[2-[[(dimethylamino)carbonyl]amino]-4-pyridinyl]methyl]amino]-N-(2-methyl-2H-indazol-6-yl)-;ZK 261991,ZK261991 |
| CAS号 | 886563-25-3 |
| 分子式 | C24H25N7O2 |
| 分子量 | 443.5 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 886563-25-3.mol |
| 结构式 |  |
886563-25-3 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
ZK-261991 是一种可口服的 VEGFR 酪氨酸酶抑制剂，抑制 VEGFR-2 活性的 IC50 值为 5 nM。
|
VEGFR2 5 nM (IC 50 ) |
ZK-261991 inhibits cellular receptor autophosphorylation in KDR-PAECs with an IC 50 of 2 nM. ZK991 inhibits VEGFR-3 autophosphorylation concentration dependently with an IC 50 of 20 nM.
ZK991 results in a significantly reduced recruitment of CD11b + and LYVE-1 + cells into the murine cornea. ZK991 significantly improves the graft survival rate after corneal transplantation.