ZK 159222
中文名称 | ZK 159222 |
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中文同义词 | 胆钙化醇杂质21(维生素D3杂质21);化合物 T17292;维生素D3杂质21(胆钙化醇杂质21) |
英文名称 | ZK 159222 |
英文同义词 | ZK 159222;SPARTCPUGRJFRS-PBDCIXLPSA-N;ZK-15922;Cyclopropanecarboxylic acid, 1-[(1R,2E,4R)-4-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(3S,5R)-3,5-dihydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-1-hydroxy-2-penten-1-yl]-, butyl ester;Cholecalciferol Impurity 21;ZK159222,ZK-159222;Cholecalciferol Impurity 21(Vitamin D3 Impurity 21);Vitamin D3 Impurity 21(Cholecalciferol Impurity 21) |
CAS号 | 156965-15-0 |
分子式 | C32H48O5 |
分子量 | 512.72 |
EINECS号 | |
相关类别 | |
Mol文件 | 156965-15-0.mol |
结构式 | ![]() |
ZK 159222 性质
熔点 | >62°C (dec.) |
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沸点 | 646.3±55.0 °C(Predicted) |
密度 | 1.13±0.1 g/cm3(Predicted) |
储存条件 | Amber Vial, -86°C Freezer, Under inert atmosphere |
溶解度 | 可溶于氯仿(少许)、乙酸乙酯(少许)、甲醇(少许) |
酸度系数(pKa) | 14.29±0.20(Predicted) |
形态 | 固体 |
颜色 | 灰白色至浅灰色 |
稳定性 | 对光敏感、对温度敏感 |
ZK159222, displayed the profile of a weak VDR agonists that requires an approximate 7-fold higher concentration than of the natural hormone 1α,25-(OH)2D3 to stabilize VDR-RXR heterodimer complex formation on a DR3-type VDRE. ZK159222 was found to belong to the category of 1α,25-(OH)2D3 analogues that stabilize an additional third functional VDR conformation, which has also been described for some agonistic 20-epi analogues. The remaining reporter gene activity that was obtained by a combined treatment of 10 nM 1α,25-(OH)2D3 with 1 μM ZK159222 is close to the partial agonistic activity of 1 μM ZK159222.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-12397 | ZK159222 | 500 μg | 5900元 | |
2024/04/30 | HY-12397 | ZK 159222 ZK159222 | 156965-15-0 | 1mg | 9800元 |