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| | BMS-1001 Basic information |
| Product Name: | BMS-1001 | | Synonyms: | BMS-1001;D-Serine, N-[[2-[(3-cyanophenyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]-5-methylphenyl]methyl]-;2113650-03-4 (free base);BMS 1001,BMS1001 | | CAS: | 2113650-03-4 | | MF: | C35H34N2O7 | | MW: | 594.65 | | EINECS: | | | Product Categories: | | | Mol File: | 2113650-03-4.mol |  |
| | BMS-1001 Chemical Properties |
| Boiling point | 801.2±65.0 °C(Predicted) | | density | 1.34±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 50 mg/mL (84.08 mM);Ethanol: Insoluble | | pka | 2.08±0.10(Predicted) | | Water Solubility | Water: Insoluble |
| | BMS-1001 Usage And Synthesis |
| Uses | BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction (IC50: 2.25 nM in a homogeneous time-resolved fluorescence binding assay). | | Biological Activity | BMS-1001 is a potent inhibitor of PD-1/PD-L1 interaction with EC50 of 253 nM. It attenuates the inhibitory effect of soluble PD-L1 on T cell receptor-mediated T lymphocyte activation. | | target | | Target | Value | PD-1/PD-L1
(Cell-free assay) | 253 nM(EC50) |
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| | BMS-1001 Preparation Products And Raw materials |
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