荧光专用试剂
中文名称 | 荧光专用试剂 |
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中文同义词 | 单溴代双满;溴代双满;溴二胺;荧光专用试剂;MBBR[单溴二胺];溴代双满,溴二胺,MONOBROMOBIMANE(MBBR );单溴二胺 MBBR;化合物 T18929 |
英文名称 | MONOBROMOBIMANE |
英文同义词 | MONOBROMOBIMANE;THIOLYTE MONOBROMOBIMANE REAGENT;THIOLYTE(R) MB;THIOLYTE(R) MB REAGENT;THIOLYTE(R) MONOBROMOBIMANE REAGENT;THIOLYTE(R) MONOBROMOBIMANE REAGENT, FLUORESCENT LABELING COMPOUND;MONOBROMOBIMANE, FOR FLUORESCENCE;BROMOBIMANE |
CAS号 | 71418-44-5 |
分子式 | C10H11BrN2O2 |
分子量 | 271.11 |
EINECS号 | |
相关类别 | 荧光探针,标记,颗粒和染色;基准试剂;Pyrazole;Fluorescent Labels and Indicators;Fluorescent Labels & Indicators;MTS & Sulfhydryl Active Reagents |
Mol文件 | 71418-44-5.mol |
结构式 |
荧光专用试剂 性质
熔点 | 152-154 °C(lit.) |
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沸点 | 327.8±44.0 °C(Predicted) |
密度 | 1.66±0.1 g/cm3(Predicted) |
储存条件 | 2-8°C |
溶解度 | 在DMF中可溶 |
酸度系数(pKa) | -3.36±0.70(Predicted) |
形态 | 粉末 |
颜色 | 粘黄色 |
最大波长(λmax) | 398 nm |
BRN | 4430959 |
稳定性 | 感光 |
生物领域应用 | Glutathione S-transferase substrates; detecting glutathione S-transferase,thiols,sulfite,homocysteine,mycothiol,sulfur compounds; thiol-reactive probes |
CAS 数据库 | 71418-44-5 |
Bromobimanes in solution (aqueous or organic solvents of medium polarity) react with small thiols [e.g., the tripeptide thiol glutathione (GSH)], and with reactive protein thiol groups (e.g., hemoglobin). The reactions of bromobimanes with thiols are second order and dependent on pH, the active nucleophile being the thiolate anion. The reaction of bromobimane with a thiolate converts the nonfluorescent agent into water-soluble fluorescent products. The neutral agents mBBr and bBBr are moderately soluble in mediumpolarity organic solvents (acetonitrile, dichloromethane), and slightly soluble in water. The quaternary salt, qBBr, and the anionic bromobimane, SBBr, are soluble in water, but less soluble in organic solvents. Bromobimanes are yellow. The highly selective, rapid reactivity of bromobimanes toward thiols, the stability and fluorescence yield of the thiol derivatives, the ease of separation of the derivatives by reversed-phase HPLC, and the availability of both cell-penetrating and nonpenetrating forms, make the use bromobimanes an extremely powerful approach to the analysis of low molecular weight biothiols.
提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | B4220 | 溴代双满 Bromobimane | 71418-44-5 | 20mg | 790元 |
2024/04/30 | B4220 | 溴代双满 Bromobimane | 71418-44-5 | 100mg | 3670元 |