- 4'-Methoxyacetophenone
-
- $45.00 / 1kg
-
2024-11-21
- CAS:100-06-1
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 20 tons
- 4'-Methoxyacetophenone
-
- $0.00 / 25kg
-
2024-11-21
- CAS:100-06-1
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 1000kg
- 4'-Methoxyacetophenone
-
- $5.00 / 25KG
-
2024-11-21
- CAS:100-06-1
- Min. Order: 1KG
- Purity: ≥99%
- Supply Ability: 200mt/year
|
| | 4'-Methoxyacetophenone Chemical Properties |
| Melting point | 36-38 °C (lit.) | | Boiling point | 152-154 °C/26 mmHg (lit.) | | density | 1.08 | | vapor pressure | 0.42Pa at 20℃ | | refractive index | 1.5470 (estimate) | | FEMA | 2005 | ACETANISOLE | | Fp | >230 °F | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | H2O: soluble2.474g/L at 20°C | | form | Crystals or Crystalline Powder | | color | White | | Odor | at 100.00 %. sweet hawthorn anisic powdery balsamic acacia | | Odor Type | anisic | | Water Solubility | insoluble | | Sensitive | Light Sensitive | | JECFA Number | 810 | | BRN | 742313 | | InChIKey | NTPLXRHDUXRPNE-UHFFFAOYSA-N | | LogP | 1.79 at 20℃ | | CAS DataBase Reference | 100-06-1(CAS DataBase Reference) | | NIST Chemistry Reference | Acetophenone, 4'-methoxy-(100-06-1) | | EPA Substance Registry System | 4'-Methoxyacetophenone (100-06-1) |
| Hazard Codes | Xn | | Risk Statements | 22-38-36/38-20/21/22 | | Safety Statements | 37-37/39-26-36 | | WGK Germany | 2 | | RTECS | AM9240000 | | TSCA | Yes | | HS Code | 29145000 | | Hazardous Substances Data | 100-06-1(Hazardous Substances Data) | | toxicity | The acute oral LD50 value in rats was reported as 1.72 g/kg (1.47-1.97 g/kg) (Moreno, 1973). The acute dermal LD50 value in rabbits was reported as > 5 g/kg (Moreno, 1973). |
| | 4'-Methoxyacetophenone Usage And Synthesis |
| Identification |
CAS.No.:
100-06-1
FL.No.:
7.038
FEMA.No.:
2005
NAS.No.:
2005
CoE.No.:
570
EINECS.No.:
202-815-9
JECFA.No.:
810
| | Description | Yellowish-white crystals with an odor similar to that of p-methylacetopheneone, suggestive of hawthorn and floral note of heliotrope, possessing a bitter and unpleasant taste. Useful in vanilla, nut, tobacco and butter flavors.
| | Regulatory Status | CoE: Approved. Bev.: 10 ppm; Food: 20 ppm
FDA: 21 CFR 172.515
FDA (other): n/a
JECFA: ADI: Acceptable. No safety concern at current levels of intake when used as a flavoring agent (2001).
| | Usage | Reported uses (ppm): (FEMA, 1994)
Alcoholic.beverages
0.0001
0.0001
Gelatins,.puddings
0.2
0.2
Nonalcoholic.beverages
7.8
150
| | Natural occurrence | Reported found in European cranberry (Vaccinium oxycoccus L.), guava fruit (Psidium guajava L.), Vitis labrusca L., tomato, anise (Pimpinella anisum L.), mentha oils, grilled and roasted beef, sherry, cloudberry (Rubus chamaemorus L.), salted and pickled plums, Illicium verum and black chokeberry (Aronia melanocarpa ell.).
| | Chemical Properties | WHITE CRYSTALS OR CRYSTALLINE POWDER | | Chemical Properties | 4-Methoxyacetophenone occurs in anise oil. It forms white crystals
(mp 38°C) with a sweet odor, reminiscent of hawthorn. 4-Methoxyacetophenone
is prepared by Friedel–Crafts acetylation of anisole. A modern process uses
??-zeolites as Friedel–Crafts catalysts in combination with a continuous flow technology.
4-Methoxyacetophenone is used in soap perfumes | | Chemical Properties | Colorless crystals or fused crystalline/Yellowish-white crystals mass. with an odor similar to that of p-methylacetopheneone, suggestive of hawthorn and floral note
of heliotrope, possessing a bitter and unpleasant taste. Useful in vanilla, nut, tobacco and butter flavors. Heavier than water, practically insoluble in water. Miscible with oils, soluble in alcohol, Relatively stable in soap and under similar,
mild-alkaline conditions. | | Occurrence | Reported found in European cranberry (Vaccinium oxycoccus L.), guava fruit (Psidium guajava L.), Vitis
labrusca L., tomato, anise (Pimpinella anisum L.), mentha oils, grilled and roasted beef, sherry, cloudberry (Rubus chamaemorus
L.), salted and pickled plums, Illicium verum and black chokeberry (Aronia melanocarpa ell.). | | Uses | 4'-Methoxyacetophenone is a solid, pale yellow flavoring agent with a hawthornlike odor. It is soluble in most fixed oils and propylene glycol, and it is insoluble in glycerin and mineral oil. It is obtained by chemical synthesis. This flavoring substance or its adjuvant may be safely used in food in the minimum quantity required to produce its intended flavor. It can be used alone or in combination with other flavoring substances or adjuvants. It is also termed p-methoxyacetophenone. | | Uses | Perfumery (for floral odors), flavoring. | | Uses | 4'-Methoxyacetophenone is used as a component of perfumes and as chemical intermediate in the manufacture of pharmaceuticals, resins, flavouring agents. And also used to study ruthenium catalyzed step growth copolymerization of 4?-methoxyacetophenone with α,ω-dienes to yield copolymers. | | Preparation | From anisole and acetyl chloride in the presence of aluminum chloride and carbon disulfide; from anisole and acetic acid
in the presence of boron trifluoride. | | Definition | ChEBI: A member of the class of acetophenones that is acetophenone substituted by a methoxy group at position 4. | | Taste threshold values | Taste characteristics at 10 ppm: sweet, anisic, fruity, cherry with powdery vanilla nuances. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 46, p. 5414, 1981 DOI: 10.1021/jo00339a036
Synthetic Communications, 26, p. 291, 1996 DOI: 10.1080/00397919608003617
Tetrahedron Letters, 35, p. 9471, 1994 DOI: 10.1016/S0040-4039(00)78574-1 | | General Description | 4′-Methoxyacetophenone undergoes biocatalytic enantioselective reduction using immobilized Rhodotorula sp. AS2.2241 cells to yield (S)-1-(4-methoxyphenyl) ethanol in a hydrophilic ionic liquid-containing co-solvent system. | | Flammability and Explosibility | Not classified | | Safety Profile | Moderately toxic by
ingestion. Human systemic effects by
inhalation: pulse rate increase without fall in
blood pressure and blood pressure elevation.
A skin irritant. Flammable liquid. When
heated to decomposition it emits acrid
smoke and irritating fumes. See also
KETONES. | | Purification Methods | Crystallise the ketone from diethyl ether/pet ether. [Beilstein 8 IV 340.] |
| | 4'-Methoxyacetophenone Preparation Products And Raw materials |
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