150493-34-8
| 中文名称 | 150493-34-8 |
|---|---|
| 中文同义词 | 1-[(4-氯苯基)甲基]-5-(三氟甲基)苯并咪唑-2-胺;1-[(4-氯苯基)甲基]-5-(三氟甲基)苯并咪唑-2-胺, >98%;化合物NS 638;1-(4-氯苄基)-5-(三氟甲基)-1H-苯并[D]咪唑-2-胺;1-[(4-氯苯基)甲基]-5-(三氟甲基)苯并咪唑-2-胺(NS-638) |
| 英文名称 | 2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole |
| 英文同义词 | 2-amino-1-(4-chlorobenzyl)-5-trifluoromethylbenzimidazole;NS 638;1H-Benzimidazol-2-amine,1-[(4-chlorophenyl)methyl]-5-(trifluoromethyl)-;1-[(4-Chlorophenyl)Methyl]-5-(Trifluoromethyl)Benzimidazol-2-Amine;NS-638;NS 638;NS638, >98%;1-(4-Chlorobenzyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine;1-(4-Chlorobenzyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2-amine[NS638 |
| CAS号 | 150493-34-8 |
| 分子式 | C15H11ClF3N3 |
| 分子量 | 325.72 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 150493-34-8.mol |
| 结构式 |  |
150493-34-8 性质
| 沸点 | 476.3±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.45±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | DMF：5mg/mL； DMSO：5mg/mL；乙醇：2mg/mL； PBS (pH 7.2)：不溶 |
| 形态 | 固体 |
| 酸度系数(pKa) | 5.15±0.10(Predicted) |
| 颜色 | 白色至米白色 |
IC50: 3.4 μM (K + -stimulated intracellular Ca 2+ -elevation)
NS-638 dose dependently inhibits K + -stimulated [45 Ca 2+ ]-uptake in chick cortical synaptosomes and 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA)- stimulated [ 3 H]GABA-release from cultured cortical neurons with IC 50 values of 2.3 and 4.3 μM, respectively. K + -stimulated intracellular Ca 2+ -elevation in cultured cerebellar granule cells is equipotently blocked with an IC 50 value of 3.4 μM. At this concentration no effect on Ca 2+ -induced contractions in K + -depolarized guinea pig taenia coli is observed. NS-638 reversibly blocks N- and L-type Ca 2+ -channels in cultured chick dorsal root ganglion cells in the concentration range of 1-30 μM.
In the mouse middle cerebral artery occlusion model, NS-638 administered i.p. (50 mg kg-1) at 1 h and 6 h post-ischemia, and once a day for the next two days, results in a 48% reduction in total infarct volume. It does not show protection against ischemic neuronal damage in the gerbil model of bilateral carotid artery occlusion.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-101428 | 150493-34-8 NS-638 | 150493-34-8 | 2mg | 500元 |
| 2024/08/19 | HY-101428 | 150493-34-8 NS-638 | 150493-34-8 | 10mM * 1mLin DMSO | 896元 |