2,4-二氯-N-(异丙基)-N-[2-[(异丙基)氨基]乙基]苯磺酰胺
| 中文名称 | 2,4-二氯-N-(异丙基)-N-[2-[(异丙基)氨基]乙基]苯磺酰胺 |
|---|---|
| 中文同义词 | 2,4-二氯-N-(异丙基)-N-[2-[(异丙基)氨基]乙基]苯磺酰胺;化合物RN-1734;2,4-二氯-N-(1-甲基乙基)-N-[2-[(1-甲基乙基)氨基]乙基]苯磺酰胺;TRPV4 ANTAGONIST I, RN-1734 CALBIOCHEM;RN-1734,TRPV4拮抗剂 |
| 英文名称 | 2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide |
| 英文同义词 | 2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide;RN 1734;2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulphonamide (RN-1734);2,4-Dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]benzenesulfonamide;TRPV4 Antagonist I, RN-1734;TRPV4 Antagonist I, RN-1734 - CAS 946387-07-1 - Calbiochem;2,4-dichloro-N-propan-2-yl-N-[2-(propan-2-ylamino)ethyl]benzenesulfonamide;Benzenesulfonamide, 2,4-dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]- |
| CAS号 | 946387-07-1 |
| 分子式 | C14H22Cl2N2O2S |
| 分子量 | 353.31 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 946387-07-1.mol |
| 结构式 | ![2,4-二氯-N-(异丙基)-N-[2-[(异丙基)氨基]乙基]苯磺酰胺 结构式](CAS/GIF/946387-07-1.gif) |
2,4-二氯-N-(异丙基)-N-[2-[(异丙基)氨基]乙基]苯磺酰胺 性质
| 储存条件 | 2-8°C |
|---|---|
| 溶解度 | 二甲基亚砜：>20mg/mL |
| 形态 | 黄色固体 |
| 颜色 | 白色至类白色 |
RN-1734 (TRPV4 Antagonist I)是一种选择性的 transient receptor potential vanilloid 4 (TRPV4) 拮抗剂，对于hTRPV4、mTRPV4和rTRPV4的IC50值分别为2.3 μM、5.9 μM和3.2 μM。RN-1734 在不改变olig2阳性细胞数量的情况下，可减轻脱髓鞘作用并抑制神经胶质活化以及抑制 tumor necrosis factor α (TNF-α) 和 interleukin 1β (IL-1β) 的产生。
| Target | Value |
|
TNF-α
() | |
|
IL-1β
() | |
|
hTRPV4
(Cell-free assay) | 2.3 μM |
|
rTRPV4
(Cell-free assay) | 3.2 μM |
|
mTRPV4
(Cell-free assay) | 5.9 μM |
RN-1734 (27 hours; 10μM) reverses the increase in the apoptotic rate of oligodendrocytes induced by CM (LPS-activated microglia group) apoptosis.
RN-1734 (27 hours; 10μM) alleviates CM-induced decreases in CNP.
Apoptosis Analysis
| Cell Line: | Microglial cells |
| Concentration: | 27 hours |
| Incubation Time: | 10μM |
| Result: | Significantly decreased the percentage of cleaved-caspase 3 positive cells. |
Western Blot Analysis
| Cell Line: | Microglial cells |
| Concentration: | 27 hours |
| Incubation Time: | 10 μM |
| Result: | Alleviated CM (with LPS only)-induced decreases in CNP. |
RN-1734 (0.5 μl; microinjector pump; daily for 5 weeks) significantly reverses the decrease in CNP protein and improves myelination in CPZ-induced demyelination mouse.
| Animal Model: | CPZ-induced demyelination mouse model (C57BL/6 male mice) |
| Dosage: | 0.5 μl (10 μM in 5% DMSO and 0.9% NaCl) |
| Administration: | Microinjector pump for 5 weeks |
| Result: | Significantly reversed the decrease in CNP protein and improved myelination in CPZ-induced demyelination mouse. |
安全信息
| WGK Germany | nwg |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-19975 | RN-1734 | 1 mg | 220元 | |
| 2024/08/19 | HY-19975 | 2,4-二氯-N-(异丙基)-N-[2-[(异丙基)氨基]乙基]苯磺酰胺 RN-1734 | 946387-07-1 | 5mg | 550元 |