甲基-五聚乙二醇-丙烯酸琥珀酰亚胺酯
中文名称 | 甲基-五聚乙二醇-丙烯酸琥珀酰亚胺酯 |
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中文同义词 | 甲氧基-六聚乙二醇-NHS 酯;甲基-五聚乙二醇-丙烯酸琥珀酰亚胺酯;甲基-六聚乙二醇-NHS 酯;单甲氧基五聚乙二醇琥珀酰亚胺酯;甲基-六聚乙二醇-琥珀酰亚胺酯;甲基-PEG5-琥珀酰亚胺酯;甲氧基5聚乙二醇活性酯;甲氧基6聚乙二醇活性酯 |
英文名称 | MPEG5-NHS |
英文同义词 | MPEG5-NHS;m-PEG6-NHS ester;mPEG5-CH2CH2COONHS Ester;mPEG6-NHS;4,7,10,13,16,19-Hexaoxaeicosanoic acid, 2,5-dioxo-1-pyrrolidinyl ester;Methyl-PEG5-NHS ester;mPEG5-SPA;mPEG5-CH2CH2COONHS/4,7,10,13,16,19-Hexaoxaeicosanoic acid, 2,5-dioxo-1-pyrrolidinyl ester |
CAS号 | 1449390-12-8 |
分子式 | C18H31NO10 |
分子量 | 421.44 |
EINECS号 | |
相关类别 | 助剂;醇类;mPEG |
Mol文件 | 1449390-12-8.mol |
结构式 | ![]() |
甲基-五聚乙二醇-丙烯酸琥珀酰亚胺酯 性质
沸点 | 502.6±60.0 °C(Predicted) |
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密度 | 1.21±0.1 g/cm3(Predicted) |
溶解度 | 溶于DMSO、DCM、DMF |
形态 | 液体 |
颜色 | 无色至浅黄 |
PEGs
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Alkyl/ether
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Non-cleavable
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ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.