N1-(4-氯苯基)-6-甲基-N5-[3-(9H-嘌呤-6-基)-2-吡啶]-1,5-异喹啉二胺
| 中文名称 | N1-(4-氯苯基)-6-甲基-N5-[3-(9H-嘌呤-6-基)-2-吡啶]-1,5-异喹啉二胺 |
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| 中文同义词 | N1-(4-氯苯基)-6-甲基-N5-[3-(9H-嘌呤-6-基)-2-吡啶]-1,5-异喹啉二胺;N1-(4-氯苯基)-6-甲基-N5-[3-(9H-嘌呤-6-基)-2-吡啶基]-1,5-异喹啉二胺;B-RAF抑制剂(B-RAF INHIBITOR 1) |
| 英文名称 | B-Raf inhibitor 1 |
| 英文同义词 | B-Raf inhibitor 1;1,5-IsoquinolinediaMine, N1-(4-chlorophenyl)-6-Methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-;N1-(4-Chlorophenyl)-6-methyl-N5-[3-(9H-purin-6-yl)-2-pyridinyl]-1,5-isoquinolinediamine;B-Raf inhibitor 1, >=98%;B-RAFcas;Raf inhibitor 1;1-N-(4-chlorophenyl)-6-methyl-5-N-[3-(7H-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamine;or Base |
| CAS号 | 1093100-40-3 |
| 分子式 | C26H19ClN8 |
| 分子量 | 478.94 |
| EINECS号 | |
| 相关类别 | 小分子抑制剂;小分子抑制剂，天然产物;细胞生物学试剂;Inhibitors |
| Mol文件 | 1093100-40-3.mol |
| 结构式 | ![N1-(4-氯苯基)-6-甲基-N5-[3-(9H-嘌呤-6-基)-2-吡啶]-1,5-异喹啉二胺 结构式](CAS/20150408/GIF/1093100-40-3.gif) |
N1-(4-氯苯基)-6-甲基-N5-[3-(9H-嘌呤-6-基)-2-吡啶]-1,5-异喹啉二胺 性质
| 沸点 | 735.4±60.0 °C(Predicted) |
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| 密度 | 1.461±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | ≥ 47.9mg/mL，溶于 DMSO |
| 形态 | 固体 |
| 酸度系数(pKa) | 8.41±0.10(Predicted) |
| 颜色 | 浅黄至黄色 |
Raf inhibitor 1是一种有效的 Raf 激酶抑制剂，作用于 B-RafWT, B-RafV600E, 和 C-Raf, Ki 分别为 1 nM, 1 nM, 和 0.3 nM。
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B-Raf 1 nM (Ki) |
B-Raf V600E 1 nM (Ki) |
c-Raf 0.3 nM (Ki) |
Raf inhibitor 1 (Compound 13) inhibits A375 and HCT-116 proliferation with IC 50 s of 0.31 and 0.72 μM, respectively. Raf inhibitor 1 (Compound 13) binds to and stabilizes B-Raf in a DFG-out, inactive conformation in which the ATP pocket is partially filled by Phe595 and Gly596 from the DFG motif. Raf inhibitor 1 (Compound 13) additionally exhibits low micromolar inhibition against wild type B-Raf cell lines, which may be due to off-target kinase activities or alternatively to pan-Raf inhibition, including Raf dimers.
安全信息
| 海关编码 | 2933998090 |
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-14177 | N1-(4-氯苯基)-6-甲基-N5-[3-(9H-嘌呤-6-基)-2-吡啶]-1,5-异喹啉二胺 Raf inhibitor 1 | 1093100-40-3 | 5mg | 800元 |
| 2024/04/30 | HY-14177 | N1-(4-氯苯基)-6-甲基-N5-[3-(9H-嘌呤-6-基)-2-吡啶]-1,5-异喹啉二胺 Raf inhibitor 1 | 1093100-40-3 | 10mM * 1mLin DMSO | 843元 |