曲札芪苷
中文名称 | 曲札芪苷 |
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中文同义词 | 曲札芪苷;白皮杉醇-3'-O-葡萄糖苷;曲札茋苷;曲札茋苷、白皮杉醇-3'-O-葡萄糖苷;反式-白皮杉醇-3-O-葡萄糖苷;白皮杉醇-3'-O-葡萄糖苷对照品;白皮杉醇-3'-O-葡萄糖苷标准品;(2S,3R,4S,5S,6R)-2-(5-((E)-3,5-二羟基苯乙烯基)-2-羟基苯氧基)-6-(羟甲基)四氢-2H-吡喃-3,4,5-三醇 |
英文名称 | Piceatannol 3'-O-glucoside |
英文同义词 | Piceatannol 3'-O-glucoside;Quzhaqigan;Piceatannol 3'-O-beta-D-glucopyranoside;trans-Piceatannol 3-glucoside;(E)-1-(3,5-dihydroxyphenyl)-2-(3-hydroxy-4-O-β-D-glucopyranose phenyl)ethylene;3,5,3',4'-trihydroxy-stilbene -3'-b-D-glucoside;Piceatannol 3-glycoside;β-D-Glucopyranoside, 5-[(1E)-2-(3,5-dihydroxyphenyl)ethenyl]-2-hydroxyphenyl |
CAS号 | 94356-26-0 |
分子式 | C20H22O9 |
分子量 | 406.38 |
EINECS号 | |
相关类别 | 植物提取物;标准品;分析试剂标准品;对照品;标准品-对照品;其它酚类;标准品 -中药标准品;标准品,对照品 |
Mol文件 | 94356-26-0.mol |
结构式 |
曲札芪苷 性质
熔点 | >219°C (dec.) |
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沸点 | 721.6±60.0 °C(Predicted) |
密度 | 1.593±0.06 g/cm3(Predicted) |
储存条件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
溶解度 | DMSO(轻微)、乙醇(轻微、超声处理)、甲醇(轻微) |
酸度系数(pKa) | 9.16±0.10(Predicted) |
形态 | 固体 |
颜色 | 白色至类白色 |
NO synthase
IC50: 11.22 μM (Arginase I), 11.06 μM (Arginase II)
Piceatannol 3'-O-glucoside (Piceatannol-3'-O-β-D-glucopyranoside; PG) is a potent component of stilbenes, inhibits the activity of arginase I and II prepared from mouse liver and kidney lysates, respectively, in a dose-dependent manner. In human umbilical vein endothelial cells, incubation of Piceatannol 3'-O-glucoside markedly blocks arginase activity and increases nitrite and nitrate (NOx) production, as measured by Griess assay. In liver lysates, incubation of different concentrations of Piceatannol 3'-O-glucoside significantly decreases arginase I activity (75±5% at 1 µM, 72±7% at 3 µM, 62±1% at 10 µM) compared to untreated control (100±9%). In kidney lysates, the residual arginase activities after incubation of 1, 3 and 10 µM Piceatannol 3'-O-glucoside are 75±6, 74±5, and 53±8%, respectively. Arginase activity is measured in the presence of different concentration of Piceatannol 3'-O-glucoside (from 0 to 120 µM) using liver lysate and kidney lysate. The 50% inhibitory concentrations (IC 50 ) are 11.22 µM for the liver lysate and 11.06 µM for kidney lysate. The values are obtained using the software of Graphpad prizm 4.0. Piceatannol 3'-O-glucoside inhibits arginase activity and increases NO production in HUVECs. Piceatannol 3'-O-glucoside inhibits lipoxygenase activity upto 66% at the concentration of 100 µM and IC 50 value is 69 µM.
In order to ascertain whether Piceatannol 3'-O-glucoside (PG) ameliorates vascular function in wild-type (WT) and atherogenic model mice [apolipoprotein E-null mice (ApoE -/- )] and to investigate the possible underlying mechanism. Preincubation of aortic vessels from WT mice fed a normal diet (ND) with Piceatannol 3'-O-glucoside attenuates vasoconstriction response to U46619 and phenylephrine (PE), while the vasorelaxant response to acetylcholine (Ach) is markedly enhanced in an endothelium-dependent manner. Piceatannol 3'-O-glucoside treatment attenuates the phenylephrine (PE)-dependent contractile response, and significantly improves the acetylcholine (Ach)-dependent vasorelaxation response in aortic rings from ApoE -/- mice fed a high-cholesterol diet (HCD). Piceatannol 3'-O-glucoside administration in the drinking water significantly reduces fatty streak formation in ApoE -/- mice fed an HCD.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-N2237 | 曲札芪苷 Piceatannol 3'-O-glucoside | 94356-26-0 | 1mg | 800元 |
2024/08/19 | HY-N2237 | 曲札芪苷 Piceatannol 3'-O-glucoside | 5 mg | 2150元 |