4-羟基查耳酮
中文名称 | 4-羟基查耳酮 |
---|---|
中文同义词 | 4-羟基查耳酮;4-羟苯基苯丙烯酮;1-(4-羟基苯基)-3-苯基丙-2-烯-1-酮;4'-羟基查耳酮 |
英文名称 | 4'-HYDROXYCHALCONE |
英文同义词 | 2-Benzal-4'-hydroxyacetophenone 2-Benzylidene-4'-hydroxyacetophenone;1-(4-Hydroxyphenyl)-3-phenyl-2-propen-1-one;1-(p-Hydroxyphenyl)-3-phenyl-2-propene-1-one;4'-Hydroxychalcone,97%;4'-Hydroxychalcone 98%;HYDROXYCHALCONE, 4-(RG);4'-Hydroxychalcone98%;HYDROXYCHALCONE, 4'- |
CAS号 | 2657-25-2 |
分子式 | C15H12O2 |
分子量 | 224.25 |
EINECS号 | |
相关类别 | 苯酚;植物提取物;中药对照品;Chalcones;Biochemistry;Flavonoids |
Mol文件 | 2657-25-2.mol |
结构式 |
4-羟基查耳酮 性质
熔点 | 174-178 °C |
---|---|
沸点 | 419.6±45.0 °C(Predicted) |
密度 | 1.191±0.06 g/cm3(Predicted) |
储存条件 | Inert atmosphere,Room Temperature |
溶解度 | DMF:30mg/mL; DMSO:30mg/mL;乙醇:30mg/mL;乙醇:PBS (pH 7.2) (1:4): 0.2 mg/mL |
形态 | 粉末晶体 |
酸度系数(pKa) | 7.72±0.15(Predicted) |
颜色 | 浅橙色至黄色至绿色 |
BRN | 2049150 |
InChIKey | UAHGNXFYLAJDIN-IZZDOVSWSA-N |
LogP | 3.650 (est) |
CAS 数据库 | 2657-25-2(CAS DataBase Reference) |
Target | Value |
NF-κB
() |
4'-Hydroxychalcone (20-40 μM ; 2 hours) inhibits TNFα-induced (20 ng/mL; 6 hours) NF-kB pathway activation in a dose-dependent manner.
4'-Hydroxychalcone (0.1-25 μM ; 8 hours) inhibits proteasome activity in a dose-dependent manner but has no effect on IKK activity.
4'-Hydroxychalcone inhibits TNFα-dependent degradation of IkBα and subsequently prevents p50/p65 nuclear translocation leading to 4'-Hydroxychalcone-inhibited expression of NF-kB target genes.
4'-Hydroxychalcone affects cancer cell viability but has no significant effect on non-transformed cell viability.
Cell Viability Assay
Cell Line: | K562 cells, Jurkat cells, U937 cells, PBMCs |
Concentration: | 5 μM, 10 μM, 20 μM, 24 μM, 28 μM, 32 μM, 40 μM, 60 μM |
Incubation Time: | 24 hours |
Result: | Affected cancer cell viability but has no significant effect on non-transformed cell viability. |
Western Blot Analysis
Cell Line: | Jurkat cells |
Concentration: | 60 μM (followed by TNFα 20 ng/mL ) |
Incubation Time: | 2 hours |
Result: | Inhibited TNFα -dependent degradation of IkBα and prevents p50/p65 nuclear translocation. |
4'-Hydroxychalcone has hepatoprotective activity against Acetaminophen induced hepatotoxicity in mice.
Animal Model: | Male albino mice(5-30 g) |
Dosage: | 25 mg/kg, 50 mg/kg, 100 mg/kg |
Administration: | Oral administration, 12h intervals, 4 doses |
Result: | Significantly reduced the mortality rate induced by Acetaminophen (1 g/kg). |
安全信息
危险品标志 | Xi |
---|---|
危险类别码 | 36/37/38 |
安全说明 | 37/39-26-37 |
海关编码 | 29145090 |