芍药苷
| 中文名称 | 芍药苷 |
|---|---|
| 中文同义词 | 芍药苷(90%);芍药苷(标准品);PAEONIFLORIN 芍药苷;芍药苷, 来源于白芍;芍药苷40%(50%、90%、98%);芍药苷40%;芍药苷50%;芍药苷提取物 |
| 英文名称 | Paeoniflorin |
| 英文同义词 | 5beta-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1h-3,4-dioxacyclobuta[cd]pentalen-1alpha(2h)-yl-beta-d-glucopyranoside;PAEONIFLORIN;5-alpha,5a-alpha,5b-alpha))-a-alph;5-methano-1h-3,4-dioxacyclobuta(cd)pentalen-1a(2h)-yl,(1ar-(1a-alpha,2-beta,3;White Peony Root P.E.;β-d-Glucopyranoside, 5b-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl, [1aR-(1aα,2β,3aα,5α,5aα,5bα)]-;beta.-d-Glucopyranoside, 5b-[(benzoyloxy)methyl]tetrahydro-5-hydroxy-2-methyl-2,5-methano-1H-3,4-dioxacyclobuta[cd]pentalen-1a(2H)-yl, [1aR-(1a.alpha.,2.beta.,3a.alpha.,5.alpha.,5a.alpha.,5b.alpha.)];Paeonia lactiflora P.E. |
| CAS号 | 23180-57-6 |
| 分子式 | C23H28O11 |
| 分子量 | 480.47 |
| EINECS号 | 245-476-2 |
| 相关类别 | 分析标准品;植物提取物;植物生化提取物;医药原料;小分子抑制剂;小分子抑制剂，天然产物;芍药苷系列;中草药成分;中药标准品;提取物;对照品;天然产物;中药对照品;标准品;对照品,标准品;原料药;中药、植物化学药;高纯植物提取物;其他生化试剂;植物成分单体;标准提取物;香精香料;标准品-对照品;标准品-中药标准品;化妆品原料;植物单体;化工原料;通用生化试剂-天然产物;植提提取物;单体;Heterocycles;Natural Plant Extract;The group of Paeoniflorin;API's;Steroids;Veterinaries;reference substance;Plant extract;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors;原料;标准品 -中药标准品;其它萜类;分析试剂-标准品;医药原料药;医药、农药及染料中间体;植物提取物单体;天然高含量单体 |
| Mol文件 | 23180-57-6.mol |
| 结构式 |  |
芍药苷 性质
| 熔点 | approximate 124℃ (dec.) |
|---|---|
| 沸点 | 498.51°C (rough estimate) |
| 密度 | 1.3044 (rough estimate) |
| 折射率 | 1.5376 (estimate) |
| 储存条件 | 2-8°C |
| 溶解度 | 甲醇（微溶，超声处理），吡啶（微溶） |
| 形态 | 粉末 |
| 酸度系数(pKa) | 11.52±0.70(Predicted) |
| 颜色 | 白色 |
| InChIKey | YKRGDOXKVOZESV-WRJNSLSBSA-N |
| CAS 数据库 | 23180-57-6(CAS DataBase Reference) |
芍药苷可抗组织细胞氧化应激损伤、抑制星形胶质细胞的激活、增强保护神经，对于纹状体及黑质多巴胺能神经细胞的损伤具有明显的拮抗作用，并可改善运动迟缓，因而可用于治疗阿尔茨海默症、帕金森病、癫痫等脑部疾病。此外，芍药苷还可以抗肿瘤、类风湿关节炎和强直性脊柱炎等自身免疫性疾病。动物实验还证明芍药苷可明显降低血糖含量、对心肺细胞具有重要的保护作用。称取40kg白芍药材，用70％乙醇浸泡过夜，回流提取2次，每次2h，滤过，合并滤液，旋转蒸发至无醇味，调整药液使每1ml药液相当于0.5g生药，备用。称取120kg(湿重)LX38树脂，装入不锈钢柱(300×2300cm)中，柱体积为60L，上样，吸附1h后，先用水300L，10％乙醇300L去除杂质，再用50％乙醇360L洗脱芍药苷和白芍苷，最后用95％乙醇再生树脂，流速为150‑200L/h，将50％乙醇部位浓缩蒸干得2.52kg，其中芍药苷纯度为24％，白芍苷为16％。
Paeoniflorin is a glycoside isolated from the root of Paeonia lactiflora. Paeoniflorin has been used as an anticonvulsant and has hypoglycemic effect. This compound reverses guanethidine-induced hypotension by activating Adenosine A1 R (the central Adenosine A1-Rs) in the brain.
化学性质
白色结晶，溶于甲醇，来源于牡丹皮、芍药、赤芍。用途
一种从芍药根中分离出的糖苷。Paeoniflorin is a glycoside isolated from the root of Paeonia lactiflora. Paeoniflorin has been used as an anticonvulsant and has hypoglycemic effect. This compound reverses guanethidine-induced hypotension by activating Adenosine A1 R (the central Adenosine A1-Rs) in the brain.
用途
一种从芍药根中分离出的糖苷。Paeoniflorin is a glycoside isolated from the root of Paeonia lactiflora. Paeoniflorin has been used as an anticonvulsant and has hypoglycemic effect. This compound reverses guanethidine-induced hypotension by activating Adenosine A1 R (the central Adenosine A1-Rs) in the brain.用途
来自芍药的根。抗心肌缺血、具抗凝抑制血小板聚集作用；解痉作用；镇痛、镇静作用；抗炎、抗溃疡作用；保肝作用；调节免疫力作用和抗高血糖作用；耐缺氧作用等。用途
中药成分来自芍药的根。中药上其解痉止痛的属性。抗心肌缺血、具抗凝抑制血小板聚集作用；解痉作用；镇痛、镇静作用；抗炎、抗溃疡作用；保肝作用；调节免疫力作用和抗高血糖作用；耐缺氧作用等。 临床应用：用于冠心病的治疗；用于老年性疾病，增强体质与免疫功能、抗炎止咳、祛痰平喘等方面，尤其是老年慢性呼吸道疾病的治疗中可作辅助药物。安全信息
| 安全说明 | 24/25 |
|---|---|
| WGK Germany | 3 |
| RTECS号 | RT1200000 |
| 海关编码 | 29389090 |
| 毒性 | LD50 ipr-mus: 9530 mg/kg YKKZAJ 89,879,69 |